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The importance of metabolic markers in the development of a second ischemic stroke


V. Shishkova(1, 2), Candidate of Medical Sciences; Professor T. Adasheva(2), MD; Professor L.
Stakhovskaya(3), MD (1)Center for Speech Pathology and Neurorehabilitation, Moscow Healthcare Department
(2)A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia (3)N.I.
Pirogov Russian National Research Medical University, Moscow

Objective. To investigate the relationship between plasma adiponectin (ADN) levels and the rate of a second noncardioembolic ischemic stroke (IS) over a three-year period Subjects and methods. The cohort observational study covered 206 patients who had experienced a first noncardioembolic IS, explored the clinical and metabolic parameters of the participants, and assessed the frequency and date of onset of a secondary IS using the Cutler-Ederer and Kaplan-Meier methods according to AND concentrations. Fasting plasma ADN concentrations (μg/ml) were determined using the BioVendor kits (Sweden) on a third-generation Reader UNIPLAN-9213 microplate photometer (PIKON, Russia). Results. The analysis of the frequency and date of onset of a second noncardioembolic IS over a three-year period showed an increased risk of its development in patients with low ADN levels (

ischemic stroke
second stroke

  1. Stahovskaja L.V., Kotov S.V., Isakova E.V. Insul't: rukovodstvo dlja vrachej. M.: OOO «Meditsinskoe informatsionnoe agentstvo», 2013; 400 s. [Stakhovskaya L.V., Kotov S.V., Isakova E.V. Insul’t: rukovodstvo dlya vrachei. M.: OOO «Meditsinskoe informatsionnoe agentstvo», 2013; 400 s. (in Russ.)].
  2. Shishkova V.N. Mehanizmy razvitija serdechno-sosudistyh zabolevanij i saharnogo diabeta tipa 2: rol' insulinorezistentnosti, giperinsulinemii i gipoadiponektinemii. Voprosy korrektsii. Sistemnye gipertenzii. 2014; 11 (2): 48–53 [Shishkova V.N. The mechanisms of developmentcardiovascular disease and type 2 diabetes: the role of insulin resistance, hyperinsulinemia and hypoadiponektinemia. Treatment and management. Systemic Hypertension. 2014; 11 (2): 48–53 (in Russ.)]. DOI: 10.26442/2075-082X_11.2.48-53
  3. Arregui M., Buijsse B., Fritsche A. et al. Adiponectin and risk of stroke: prospective study and meta-analysis. Stroke. 2014; 45 (1): 10–7. DOI: 10.1161/STROKEAHA.113.001851 Bang O.Y., Savel J.L., Ovbiagele V. et al. Adiponectin levels in patients with intracranial atherosclerosis. Neurology. 2007; 68 (22): 1931–7. DOI: 10.1212/01.wnl.0000263186.20988.9f
  4. Shishkova V.N., Adasheva T.V., Remennik A.Ju. i dr. Prognosticheskaja znachimost' kliniko-antropometricheskih, biohimicheskih, metabolicheskih, sosudisto-vospalitel'nyh i molekuljarno-geneticheskih markerov v razvitii pervogo ishemicheskogo insul'ta. Zhurnal nevrol. i psihiatr. im. S.S. Korsakova. 2018; 118 (2): 4–11 [Shishkova V.N., Adasheva T.V., Remenik A.Yu. et al. Prognostic significance of clinical-anthropometric, biochemical, metabolic, vascular-inflammatory and molecular-genetic markers in the development of the first ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2018; 118 (2): 4–11 (in Russ.)].
  5. Dastani Z., Hivert M.F., Timpson N. et al. Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals. PLoS. Genet. 2012; 8 (3): e1002607. DOI: 10.1371/journal.pgen.1002607
  6. Kawai T., Ohishi M., Takeya Ya. et al. Adiponectin single nucleotide polymorphism is a genetic risk factor for stroke trough high pulse wave pressure: a cohort study. J Atheroscler Thromb. 2013; 20 (2): 152–60. DOI: 10.5551/jat.14696
  7. Chen L., Sun K.X., Juan J. et al. CDH13 genetic polymorphisms, adiponectin and ischemic stroke: a chine family-based sib-pair study. Biomed Environ Sci. 2017; 30 (1): 35–43. DOI: 10.3967/bes2017.004