Вirth defects: the role of P-glycoprotein
DOI: https://doi.org/10.29296/25877305-2020-07-04
Issue:
7
Year:
2020
ABC transporters and mainly P-glycoprotein play critical physiological and protective roles in
during reproductive processes. The P-glycoprotein, encoded by the ABCB1 gene, is suggested to protect the
developing embryo from drugs which are substrates of P-glycoprotein and other xenobiotic exposures. It is
increasingly recognized that the activity of these transporters is affected by genetic polymorphisms. The
article looks into the recent studies exploring the association between P-glycoprotein polymorphisms and the
risk of fetal birth defects associated with medication use during pregnancy.
Keywords:
obstetrics and gynecology
pregnancy
birth defects
drugs
fetus
placenta
drug transporters
P-glycoprotein
polymorphism
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