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Вirth defects: the role of P-glycoprotein

DOI: https://doi.org/10.29296/25877305-2020-07-04
Issue: 
7
Year: 
2020

T. Pikuzа1; Professor R. Chilova(1), MD; E. Sоkоvа1, 2, Candidate of Medical Sciences; R.
Kazakov(1), Candidate of Biological Sciences; K. Akopov(3); O. Astsaturova(1), Candidate of Medical Sciences
(1)I.M. Sechenov First Moscow State Medical University (Sechenov University) (2)Scientific Centre for Expert
Evaluation of Medicinal Products, Moscow (3)State Clinical Hospital named. S.S. Yudina, Moscow

ABC transporters and mainly P-glycoprotein play critical physiological and protective roles in during reproductive processes. The P-glycoprotein, encoded by the ABCB1 gene, is suggested to protect the developing embryo from drugs which are substrates of P-glycoprotein and other xenobiotic exposures. It is increasingly recognized that the activity of these transporters is affected by genetic polymorphisms. The article looks into the recent studies exploring the association between P-glycoprotein polymorphisms and the risk of fetal birth defects associated with medication use during pregnancy.

Keywords: 
obstetrics and gynecology
pregnancy
birth defects
drugs
fetus
placenta
drug transporters
P-glycoprotein
polymorphism



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