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What conclusions should be drawn from the association between liver diseases and cholelithiasis?

DOI: https://doi.org/10.29296/25877305-2020-06-04
Issue: 
6
Year: 
2020

Yu. Tonkikh, Candidate of Medical Sciences; A. Vasyutin, Candidate of Medical Sciences; Professor V. Tsukanov, MD Research Institute for Medical Problems of the North (Separate Subdivision), Federal Research Center «Krasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences», Krasnoyarsk

The authors reviewed current data, which could establish a pronounced association between the prevalence of cholelithiasis and liver diseases. A century-and-a-half discussion about the prevalence of the basic concepts of the pathogenesis of cholelithiasis led to the unification of metabolic and infectious theories. Currently, surgical tactics involving cholecystectomy in individuals with symptomatic or complicated cholelithiasis predominates in an approach to treating gallstones. A multidisciplinary view on the diagnosis, pathogenesis, treatment, and prevention of cholelithiasis and the recognition of a close relationship between the functional state and pathology of the liver and biliary tract justifies the feasibility of a thorough diagnosis of pathology of the liver and correction of its functional state in patients with cholelithiasis. Ursodeoxycholic acid is a good example of therapy that improves both the functional state of the liver and that of the biliary tract.

Keywords: 
hepatology
gastroenterology
cholelithiasis
gallstones
non-alcoholic fatty liver disease
ursodeoxycholic acid
pathogenesis
treatment



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