THE FEATURES OF NEUROIMMUNE ENDOCRINE AND GERIATRIC STATUS IN PATIENTS WITH CORONARY ARTERY DISEASE SCHEDULED CORONARY ARTERY BYPASS SURGERY

DOI: https://doi.org/10.29296/25877305-2019-07-09
Номер журнала: 
7
Год издания: 
2019

А. Khmelnitsky(1), Candidate of Medical Sciences; Professor К. Prashchayeu(2), MD; D. Elistratov(3) 1-Saint-Petersburg Institute of Bioregulation and gerontology 2-Federal scientific and clinical center of specialized types of medical care and medical technologies of the Federal medical and biological Agency, Moscow 3-OOO Parafarm, Penza

The article presents an overview of the features of neuroimmunoendocrine and geriatric status in patients with coronary heart disease, which are scheduled on a planned coronary artery bypass grafting. The possible effect of the dynamics of proinflammatory immune response on the development of adverse events in such patients is described. It is shown that the frailty syndrome and the main geriatric syndromes can be predictors of adverse events after a planned coronary artery bypass grafting. The data of recent studies on biomarkers of fatal and nonfatal complications, as well as innovative developments of ways to identify the risks of adverse events in such patients are presented.
Keywords: 
cardiology, gerontology, aorto-coronary bypass grafting, geriatric status, elderly age, neuroimmunoendocrine disorders, biomarkers, Osteomed

Список литературы: 
  1. Il'nitskij A.N., Proschaev K.I., Varavina L.Ju. i dr. Starcheskaja astenija (frailty): oksidativnye i nejroimmunoendokrinnye izmenenija // Rossijskij semejnyj vrach. – 2013; 2: 37–41 [Ilnitski A.N., Prashchaeu K.I., Varavina L.U. et al. Frailty: oxidative and neciroimmcinoendocrinological changes // Rossiiskii semeinyi vrach. – 2013; 2: 37–41 (in Russ.)].
  2. Goto T., Maekawa K. Cerebral dysfunction after coronary artery bypass surgery // J. Anesth. – 2014; 28 (2): 242–8.
  3. Shalenkova M.A., Muhametova E.T. Rol' markerov nekroza i vospalenija v prognozirovanii ostryh form ishemicheskoj bolezni serdtsa // Klinicheskaja meditsina. – 2013; 11: 14–20 [Shalenkova E.T., Mukhametova M.A., Mikhailova Z.D. The role of necrosis and inflammation markers in prognostication of acute coronary heart disease // Klinicheskaya meditsina. – 2013; 11: 14–20 (in Russ.)].
  4. Pustavoitau A., Barodka V., Sharpless N. et al. Role of senescence marker p16NK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults // Exp. Gerontol. – 2016; 74: 29–36.
  5. Rothenburger M., Tjan T., Schneider M. The impact of the pro- and anti-inflammatory immune response on ventilation time after cardiac surgery // Cytometry B. Clin. Cytom. – 2013; 53 (1): 70–4.
  6. Börgermann J., Lazouski K., Kuhn J. 1,25-Dihydroxyvitamin D fluctuations in cardiac surgery are related to age and clinical outcome // Crit. Care Med. – 2012; 40 (7): 273–81.
  7. Martinez-Comendador J., Alvarez J., Sierra J. Preoperative statin therapy in cardiac surgery is more effective in patients who display preoperative activation of the inflammatory system // Tex Heart Inst. J. – 2013; 40 (1): 42–9.
  8. Willham K., Covinsky K., Widera E. Geriatrics Literature 2017 Year in Review // J. Am. Geriatr. Soc. – 2018; 66 (9): 1665–9.
  9. Skaar E., Eide L., Norekvål T. et al. A novel geriatric assessment frailty score predicts 2-year mortality after transcatheter aortic valve implantation // Eur. Heart J. Qual. Care Clin. Outcomes. – 2019; 5 (2): 153–60.
  10. Seco M., Edelman J., Forrest P. et al. Geriatric cardiac surgery: chronology vs. Biology // Heart Lung Circ. – 2014; 23 (9): 794–801.
  11. Partridge J., Harari D., Martin F. et al. Randomized clinical trial of comprehensive geriatric assessment and optimization in vascular surgery // Br. J. Surg. – 2017; 104 (6): 679–87.
  12. Marullo A., Irace F., Vitulli P. et al. Recent Developments in Minimally Invasive Cardiac Surgery: Evolution or Revolution? // Biomed. Res. Int. – 2015; 15: 483–525.
  13. Janssen T., Mosk C., van Hoof-de Lepper C. et al. A multicomponent prehabilitation pathway to reduce the incidence of delirium in elderly patients in need of major abdominal surgery: study protocol for a before-and-after study // BMC Geriatr. – 2019; 19 (1): 87.
  14. Jonker F., Giacovelli J., Muhs B. et al. Trends and outcomes of endovascular and open treatment of thoracic aortic injury // J. Vasc. Surg. – 2010; 51: 565–71.
  15. Ganapathi A., Englum B., Hanna J. et al. Frailty and risk in proximal aortic surgery // J. Thorac. Cardiovasc. Surg. – 2014; 147 (1): 186–91.
  16. Strukov V., Elistratov D., Balykova L. i dr. Vlijanie Osteomeda Forte na gormonal'nyj status i techenie osteoporoza u zhenschin s defitsitom androgenov v postmenopauze // Vrach. – 2015; 3: 28–32 [Strukov V., Elistratov D., Balykova L. et al. Effect of Osteomed Forte on hormonal status and course of osteoporosis in postmenopausal women with androgen deficiency // Vrach. – 2015; 3: 28–32 (in Russ.)].
  17. Strukov V., Kislov A., Elistratov D. i dr. Personifitsirovannyj podhod v terapii osteoporoza u pozhilyh // Vrach. – 2015; 6: 51–3 [Strukov V., Kislov A., Elistratov D. et al. Personified approach in the therapy of osteoporosis in elderly patients // Vrach. – 2015; 6: 51–3 (in Russ.)].
  18. Strukov V.I., Katjushina Ju.G., Filippova O.V. Osteomed – effektivnyj reguljator mineral'noj plotnosti kostej i zakrytija polostnyh obrazovanij pri lechenii presenil'nogo i senil'nogo osteoporoza // Poliklinika. – 2013; 1 (1): 90–1 [Strukov V.I., Katyushina Yu.G., Filippova O.V. Osteomed as an effective regulator of bone mineral density and closing of bone cavities during pre-senile and senile osteoporosis // Poliklinika. – 2013; 1 (1): 90–1 (in Russ.)].
  19. Strukov V.I., Elistratov D.G. Izvestnye i novye tehnologii v lechenii i profilaktike osteoporoza. Metodicheskie rekomendatsii / Penza, 2014; s. 46 [Strukov V.I., Elistratov D.G. Izvestnye i novye tekhnologii v lechenii i profilaktike osteoporoza. Metodicheskie rekomendatsii / Penza, 2014; s. 46 (in Russ.)].
  20. Mihno L., Levshin I., Polikarpochkin A. i dr. Ispol'zovanie farmakologicheskih sredstv dlja sohranenija, vosstanovlenija i povyshenija rabotosposobnosti junyh hokkeistov // Vrach. – 2018; 29 (9): 67–71 [Mikhno L., Levshin I., Polikarpochkin A. et al. Use of pharmacological agents to preserve, restore, and improve the performance of young hockey players // Vrach. – 2018; 29 (9): 67–71 (in Russ.)] https://doi.org/10.29296/25877305-2018-09-17