PERSONALIZED PREVENTION OF AGE-RELATED PATHOLOGY AS ONE OF HEALTH IMPROVEMENT CONDITIONS IN RUSSIAN POPULATION

DOI: https://doi.org/10.29296/25877305-2019-07-03
Номер журнала: 
7
Год издания: 
2019

Professor V. Havinson(1), MD, Corresponding Member of the Russian Academy of Sciences; A. Ryvkin(3), MD; Professor S. Trofimova(2), MD; Professor A. Ilnitski(2), MD; Professor A. Trofimov(1), MD; Professor K. Prashchayeu(2), MD; A. Lyshchev(3), Candidate of Medical Sciences 1-St.Petersburg Bioregulation and Gerontology Institute 2-Academy of Postgraduate Education under the Federal State Budgetary Unit «Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency», Moscow 3-City Hospital №31, Saint Petersburg, Russia

Disorder of neuroimmunoendocrine system in human play the main role in aging pathogenesis processes and, consequently, in frailty. The use of scientifically proven geroprotectors with epigenetic activity is a targeted way to achieve healthy longevity.
Keywords: 
gerontology, prevention, aging, melatonin

Список литературы: 
  1. Prognoz dolgosrochnogo sotsial'no-ekonomicheskogo razvitija Rossijskoj Federatsii na period do 2030 goda / M.: Minekonomrazvitija RF, 2013 [Prognoz dolgosrochnogo social’no-ehkonomicheskogo razvitiya Rossijskoj Federacii na period do 2030 goda / M.: Minehkonomrazvitiya RF, 2013 (in Russ.)].
  2. Programma «Profilaktika vozrastnoj patologii i uskorennogo starenija, snizhenie prezhdevremennoj smertnosti ot biologicheskih prichin i prodlenie trudosposobnogo perioda zhizni naselenija». Metodicheskie rekomendatsii / SPb: KOSTA, 2008; 72 s. [Programma «Profilaktika vozrastnoj patologii i uskorennogo stareniya, snizhenie prezhdevremennoj smertnosti ot biologicheskih prichin i prodlenie trudosposobnogo perioda zhizni naseleniya». Metodicheskie rekomendacii / SPb: KOSTA, 2008; 72 s. (in Russ.)].
  3. Morozov V.G., Havinson V.H. Novyj klass biologicheskih reguljatorov mnogokletochnyh sistem – tsitomediny // Uspehi sovrem. biol. – 1983; 96 (3): 339–52 [Morozov V.G., Havinson V.H. Novyj klass biologicheskih regulyatorov mnogokletochnyh sistem – citomediny // Uspekhi sovrem. biol. – 1983; 96 (3): 339–52 (in Russ.)].
  4. Morozov V.G., Havinson V.H. Rol' kletochnyh mediatorov (tsitomedinov) v reguljatsii geneticheskoj aktivnosti // Izvestija AN SSSR. Ser.biol. – 1984; 4: 581–7 [Morozov V.G., Havinson V.H. Rol’ kletochnyh mediatorov (citomedinov) v regulyacii geneticheskoj aktivnosti // Izvestiya AN SSSR. Ser.biol. – 1984; 4: 581–7 (in Russ.)].
  5. Havinson V.H. Molekuljarnye osnovy peptidergicheskoj regljatsii starenija / SPb: Nauka, 2011; 174 s. [Havinson V.H. Molekulyarnye osnovy peptidergicheskoj reglyacii stareniya / SPb: Nauka, 2011; 174 s. (in Russ.)].
  6. Havinson V.H., Solov'ev A.Ju., Tarnovska S.I. i dr. Mehanizm biologicheskoj aktivnosti korotkih peptidov: proniknovenie v kletku i epigeneticheskaja reguljatsija ekspressii genov // Uspehi sovr. biol. – 2013; 133 (2): 197–203 [Havinson V.H., Solov’ev A.YU., Tarnovska S.I. et al. Mekhanizm biologicheskoj aktivnosti korotkih peptidov: proniknovenie v kletku i ehpigeneticheskaya regulyaciya ehkspressii genov» // Uspekhi sovr. biol. – 2013; 133 (2): 197–203 (in Russ.)].
  7. Khavinson V.Kh., Malinin V.V. Gerontological Aspects of Genom Peptide Regulation / Basel (Switzerland): Karger AG, 2005; 104 p.
  8. Trofimov A., Trofimova S. 15-letnij opyt primenenija molekuljarno-geneticheskogo issledovanija v klinicheskoj praktike // Vrach. – 2015; 6: 66–8 [Trofimova A., Trofimova S. 15 years’ experience with molecular genetic examination used in clinical practice // Vrach. – 2015; 6: 66–8 (in Russ.)].
  9. Trofimova S., Trofimov A., Korjakin A. i dr. Personifitsirovannaja profilaktika zabolevaemosti v uslovijah Krajnego Severa // Vrach. – 2016; 6: 64–6 [Trofimova S., Trofimov A., Koryakin A. et al. Personified prevention of diseases under the conditions of the Far North // Vrach. – 2016; 6: 64–6 (in Russ.)].
  10. Kvetnaja T.V., Knjaz'kin I.V., Kvetnoj I.M. Melatonin – nejroimmunoendokrinnyj marker vozrastnoj patologii / SPb: DEAN, 2005 [Kvetnaya T.V., Knyaz’kin I.V., Kvetnoi I.M. Melatonin – neiroimmunoehndokrinnyi marker vozrastnoj patologii / SPb: DEAN, 2005 (in Russ.)].
  11. Takubo K., Izumiyama-Shimomura N., Honma N. et al. Telomere lengths are characteristic in each human individual // Exp. Gerontol. – 2002; 37: 523–31.
  12. Havinson V.H., Trofimova S.V., Trofimova A.V. i dr. Innovatsionnye tehnologii v diagnostike prezhdevremennogo starenie. Uchebnoe posobie / SPb: KOSTA, 2017; 32 s. [Havinson V.H., Trofimova S.V., Trofimova A.V. et al. Innovacionnye tekhnologii v diagnostike prezhdevremennogo starenie. Uchebnoe posobie / SPb: KOSTA, 2017; 32 s. (in Russ.)].
  13. Bondarev I.E., Butjugov A.A., Smirnova T.D. i dr. Induktsija telomeraznoj aktivnosti i elongatsija telomer peptidom epitalon v somaticheskih kletkah cheloveka // Med. immunol. – 2003; 5: 193–4 [Bondarev I.E., Butyugov A.A., Smirnova T.D. et al. Indukciya telomeraznoj aktivnosti i ehlongaciya telomer peptidom ehpitalon v somaticheskih kletkah cheloveka // Med. immunol. – 2003; 5: 193–4 (in Russ.)].
  14. Harley C. et al. A Natural Product Telomerase Activator As Part of a Health Maintenance Program // Rejuvenation. Res. – 2011; 14 (1): 45–56.
  15. Lawrence B. «Khavinson peptides»: a telomerase activation protocol lengthens telomeres in humans. Abstr. “Effective current approaches in anti-aging medicine and gerontology / Stockholm, Sweden, 2018; 61–2.
  16. Paul L. et al. Diet, nutrition and telomere length // J. Nutr. Biochem. – 2011; 22 (10): 895–901.
  17. Khavinson V.Kh. Peptides and aging // Neuroendocrinol. Lett. – 2002; 23 (3): 144.
  18. Anisimov V.N. Molekuljarnye i fiziologicheskie mehanizmy starenija. V 2 t. T.1 / SPb: Nauka, 2008; 481 s. [Anisimov V.N. Molekulyarnye i fiziologicheskie mekhanizmy stareniya. V 2 t. T. 1. / SPb: Nauka, 2008; 481 s. (in Russ.)].
  19. Anisimov V.N., Vinogradova I.A. Svetovoj rezhim, bioritmy i starenie organizma // Vestnik esteticheskoj meditsiny. – 2011; 10 (1): 42–51 [Anisimov V.N., Vinogradova I.A. Light regime, biorythms and organism aging // Vestnik ehsteticheskoj mediciny. – 2011; 10 (1): 42–51 (in Russ.)].
  20. Korkushko O.V., Havinson V.H., Shatilo V.B. Pineal'naja zheleza: puti korrektsii pri starenii / SPb: Nauka, 2006; 204 s. [Korkushko O.V., Havinson V.H., SHatilo V.B. Pineal’naya zheleza: puti korrekcii pri starenii / SPb: Nauka, 2006; 204 s. (in Russ.)].
  21. Korkushko O.V., Havinson V.H., Shatilo V.B. i dr. Geroprotektornyj effekt peptidnogo preparata epifiza epitalamina u pozhilyh ljudej s uskorennym stareniem // Bjull. eksp. biol. i med. – 2006; 142 (9): 328–32 [Korkushko O.V., Havinson V.H., SHatilo V.B. et al. Geroprotektornyj ehffekt peptidnogo preparata ehpifiza ehpitalamina u pozhilyh lyudej s uskorennym stareniem // Byull. ehksp. biol. i med. – 2006; 142 (9): 328–32 (in Russ.)].
  22. Balashova S.N., Zhernakov G.L., Dudkov A.V. Primenenie peptidnyh bioreguljatorov u lits pozhilogo vozrasta s narushenijami psihoemotsional'nogo sostojanija // Uspehi gerontologii. – 2008; 21 (3): 448–52 [Balashova S.N., ZHernakov G.L., Dudkov A.V. Primenenie peptidnyh bioregulyatorov u lic pozhilogo vozrasta s narusheniyami psihoehmocional’nogo sostoyaniya // Uspekhi gerontologii. – 2008; 21 (3): 448–52 (in Russ.)].
  23. Il'nitskij A., Proschaev K., Varavina L. i dr. Sindrom starcheskoj astenii (frailty): klinika, diagnostika, lechenie, profilaktika // Vrach. – 2014; 6: 3–5 [Ilnitsky A., Proshchaev K., Varavina L. et al. Senile asthenia (Frailty) syndrome: clinical picture, diagnosis, treatment, prevention // Vrach. – 2014; 6: 3–5 (in Russ.)].
  24. Il'nitskij A.N., Proschaev K.I. Spetsializirovannyj geriatricheskij osmotr // Gerontologicheskij zhurnal im. V.F. Kuprevicha. – 2012; 4–5: 66–84 [Ilnitsky A.N., Proshchaev K.I. Specialized geriatric examination // Gerontologicheskij zhurnal im. V.F. Kuprevicha. – 2012; 4–5: 66–84 (in Russ.)].
  25. Buckingham E. et al. The role of telomeres in the ageing of human skin // Exp. Dermatol. – 2011; 20 (4): 297–302.