Genetic markers of predisposition to psoriasis

DOI: https://doi.org/10.29296/25877305-2018-10-06
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Issue: 
10
Year: 
2018

K. Baskaev(1), Candidate of Biological Sciences; S. Shumilova(1), Professor I. Korsunskaya(2), MD; M. Denieva(3), Candidate of Medical Sciences; O. Voronko(1), Candidate of Biological Sciences 1-V.N. Orekhovich Research Institute of Biomedical Chemistry, Moscow 2-Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow 3-Chechen State University, Grozny

The polymorphic markers of +61A>g EGF, R501X, and 2282del4 FLG alleles and genotypes were comparatively analyzed in patients with psoriasis and healthy individuals. The FLG RX genotype and X allele were associated with an increased risk for psoriasis.
Keywords: 
dermatology
filaggrin
epidermal growth factor
psoriasis
psoriatic arthritis
genetic markers

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