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DOI: https://doi.org/10.29296/25877305-2018-02-04
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Professor N. Potekaev (1, 2), MD; I. Danilin (3); Professor I. Korsunskaya (2, 4), MD; A. Kostolevskaya (2), MD; Z. Nevozinskaya (1, 2); Professor M. Artemyeva (3), MD 1-N.I. Pirogov Russian National Research Medical University, Moscow 2-Moscow Research-and-Practical Center of Dermatovenereology and Cosmetology, Moscow Healthcare Department 3-Peoples’ Friendship University of Russia, Moscow 4-Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow

The paper considers the presumed mechanisms of the etiology and pathogenesis of a common skin disease, such as atopic dermatitis (AD), from the point of view of psychosomatic theories and models in modern medicine. It analyzes the literature data suggesting that the peptidergic and immune systems are actively involved in the development of key symptoms of the disease. The systems of monoamine neurotransmitters (dopamine, noradrenaline, and serotonin) participating in the development and functioning of all mental processes (emotions, thinking, perception, etc.) were found to also play an important role in the pathogenesis of AD. There are examples of successfully using drugs from the groups of neuroleptics, antidepressants, tranquilizers in AT.

atopic dermatitis

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  1. Peters E., Kuhlmei A. Immunology of psoriasis // Brain Behav. Immunol. – 2005; 19: 252–62.
  2. Lind N., Nordin M., Palmquist E. et al. Psychological distress in asthma and allergy: the Vasterbotten Environmental Health Study // Psychol. Health Med. – 2014. DOI: 10.1080/13548506.2013.806814.
  3. Noh S., Kim M., Park C. et al. Comparison of the psychological impacts of asymptomatic and symptomatic cutaneous diseases: Vitiligo and atopic dermatitis // Ann. Dermatol. – 2013; 25 (4): 454–61. DOI: 10.5021/ad.2013.25.4.454.
  4. Baron S., Cohen S., Archer C. et al. Guidance on the diagnosis and clinical management of atopic eczema // Clin. Exp. Dermatol. – 2012; 37 (Suppl. 1): 7–12. DOI: 10.1111/j.1365-2230.2012.04336.x.
  5. Kwon J., Park E., Lee M. et al. Does Stress Increase the Risk of Atopic Dermatitis in Adolescents? Results of the Korea Youth Risk Behavior Web-Based Survey (KYRBWS-VI) // PLoS One. – 2013; 8 (8): e67890. DOI: 10.1371/journal.pone.0067890.
  6. Mizawa M., Yamaguchi M., Ueda C. et al. Stress evaluation in adult patients with atopic dermatitis using salivary cortisol // Biomed Res. Int. – 2013; 2013: 138027. DOI: 10.1155/2013/138027.
  7. Buske-Kirschbaum A., Ader R. Endocrine and Immune Responses to Stress in Chronic Inflammatory Skin Disorder (Atopic Dermatitis). In: Psychoneuroimmunology (Fourth Edition), 2007.
  8. Teresiak-Mikołajczak E., Czarnecka-Operacz M., Jenerowicz D. et al. Neurogenic markers of the inflammatory process in atopic dermatitis: Relation to the severity and pruritus // Postep. Dermatologii i Alergol. – 2013; 30 (5): 286–92. DOI: 10.5114/pdia.2013.38357/
  9. Schmid-Ott G., Jaeger B., Meyer S. et al. Different expressionof cytokine and membrane molecules by circulating lymphocytes on acute mentalstress in patients with atopic dermatitis in comparison with healthy controls // J. Allergy Clin. Immunol. – 2001; 108: 455–62.
  10. Hall J., Cruser D., Podawiltz A. et al. Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis // Dermatol. Res. Pract. – 2012; 2012: DOI: 10.1155/2012/403908.
  11. Dorozhenok I.Ju., L'vov A.N. Psihicheskie rasstrojstva v dermatologicheskoj praktike / M., 2006; s. 25.
  12. Korkina M.V., Marilov V.V. Rol' psihosomaticheskih tsiklov v geneze psihosomaticheskih zabolevanij // Zhurn. nevrol. i psihiat. im. S.S. Korsa-
  13. kova. – 1998; 98 (11): 30–2.
  14. Luss L.A. Rol' psihosomaticheskih rasstrojstv pri atopicheskom dermatite. Vozmozhnosti korrektsii // Doktor.ru. – 2010; 2 (53): 55–9.
  15. Ostrishko V.V., Ivanov O.L., Novoselov V.S. i dr. Diagnostika i korrektsija pogranichnyh psihicheskih rasstrojstv u bol'nyh atopicheskim dermatitom (chast' 1) // Vestn. dermatol. i venerol. – 1998; 2: 34–7.
  16. Lopes C., Pinto L., Leite C. et al. Personality Traits May Influence the Severity of Atopic Dermatitis in Adult Patients: A Pilot Study // J. Investig. Allergol. Clin. Immunol. – 2016; 26 (3): 198–9. DOI: 10.18176/jiaci.0056
  17. Takaki H., Ishii Y. Sense of coherence, depression, and anger among adults with atopic dermatitis // Psychol. Health Med. – 2013; 18 (6): 725–34. DOI: 10.1080/13548506.2013.766353.
  18. Michenko A.B., L'vov A.N. Psihosomaticheskie aspekty atopicheskogo dermatita: klassicheskie kanony i novye predstavlenija // Ros. zhurn. kozhnyh i venericheskih boleznej. – 2008; 4: 11–8.
  19. González E., Sanguino R., Franco M. Bupropion in atopic dermatitis // Pharmacopsychiatry. – 2006; 39 (6): 229.
  20. Kim Kwangmi. Neuroimmunological mechanism of pruritus in atopic dermatitis focused on the role of serotonin // Biomol. Therap. – 2012; 20 (6): 506–12.
  21. Shimoda T., Liang Z., Suzuki H. et al. Inhibitory effects of antipsychotic and anxiolytic agents on stress induced degranulation of mouse dermal mast cells // Clin. Exp. Dermatol. – 2010; 35: 531–6.
  22. El-Nour H., Lundeberg L., Abdel-Magid N. et al. Serotonergic mechanisms in human allergic contact dermatitis // Acta Derm. Venereol. – 2007; 87: 390–6.
  23. Lonne-Rahm, S., Rickberg H., El-Nour H. et al. Neuroimmune mechanisms in patients with atopic dermatitis during chronic stress // J. Eur. Acad. Dermatol. Venereol. – 2008; 22: 11–8.