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CYP3A5*3 GENE POLYMORPHISM AND HALOPERIDOL EQUILIBRIUM CONCENTRATION IN ALCOHOL DEPENDENCE

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Issue: 
9
Year: 
2017

M. Zastrozhin, Candidate of Medical Sciences; A. Chernikov; Associate Professor E. Grishina, Candidate of Biological Sciences; I. Miroshnichenko, MD; N. Baimeeva; D. Kubarev; A. Romanov, Candidate of Medical Sciences; M. Vdovina; Associate Professor L. Savchenko, Candidate of Medical Sciences; Professor E. Bryun, MD; Professor D. Sychev, Corresponding Member of the Russia Academy of Sciences Moscow Research and Practical Center for Narcology

The investigation has shown that CYP3A5*3 polymorphism has no significant impact on CYP3A4 activity and haloperidol equilibrium concentration in patients with alcohol dependence.

Keywords: 
psychiatry-narcology
haloperidol
biotransformation
CYP3A5*3
CYP3A4
adverse drug reactions
pathological alcohol craving
equilibrium concentration



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