THE TIME COURSE OF CHANGES IN THE CONCENTRATION OF BRAIN-DERIVED NEUROTROPHIC FACTOR DURING THIAPRIDE THERAPY FOR MENTAL CONFUSION

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Issue: 
6
Year: 
2017

Professor L. Kruglov (1), MD; M. Kumov (2); N. Molodtsova (2); I. Goloshchapov (2) 1-V.M. Bekhterev Saint Petersburg Psychoneurology Research Institute University 2-P.P. Kashchenko Saint Petersburg Mental Hospital One

The paper considers the clinical results of using thiapride and quetiapine in patients with mental confusion and the time course of changes in the concentration of brain-derived neurotrophic factor (BDNF) during the above treatment. The changes in the BDNF concentration were characterized by its reduction with the similar clinical results of therapy. There are possible explanations for this and a conclusion about the similarity of the effectiveness and safety of using thiapride and the atypical antipsychotic in the aspect of their potential effects on the processes controlled by BDNF.
Keywords: 
psychiatry
brain-derived neurotrophic factor
dementia
mental confusion
thiapride

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References: 
  1. Hschieh T., Fong T., Marcantonio E. et al. Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence // J. Gerontol. Biol. Med. Sci. – 2008; 63 (7): 764–72.
  2. Campbell N., Boustani M., Ayub A. et al. Pharmacological management of delirium in hospitalized adults--a systematic evidence review // J. Gen. Intern. Med. – 2009; 24 (7): 848–53.
  3. Fong T., Tulebaev S., Inouye S. Delirium in elderly adults: diagnosis, prevention and treatment // Nat. Rev. Neurol. – 2009; 5 (4): 210–20.
  4. Diniz B., Reynolds C., Begley M. et al. Brain-derived neurotrophic factor levels in late-life depression and co-morbid mild cognitive impairment: a longitudinal study // J. Psychiatr. Res. – 2014; 49 (2): 96–101.
  5. Platenik J., Fisar Z., Buchal R. et al. GSK3B, CREB, and BDNF in peripheral blood of patients with Alzheimer’s disease and depression // Progress in neuropsychopharmacol. biol. psychiat. – 2014; 50 (3): 83–93.
  6. Budni J., Bellettini-Santos T., Francielle M. et al. The involvement of BDNF, NGF and GDNF in aging and Alzheimer’s disease // Aging Dis. – 2015; 5 (6): 331–41.
  7. Passaro A., Nora E., Morieri M. et al. Brain-derived neurotrophic factor plasma levels: relationship with dementia and diabetes in the elderly population // J. Gerontol. Biol. Sci. Med. Sci. – 2015; 70 (3): 294–302.
  8. Kruglov L.S., Belentsova T.M., Belentsova V.S. Primenenie preparata tiaprid pri sostojanijah ostroj psihicheskoj sputannosti v pozdnem vozraste // Ros. psihiat. zhurn. – 2012; 4: 53–7.
  9. Ha’la M. Pathophysiology of postoperative delirium: systemic inflammation as a response to surgical trauma causes diffuse microcirculatory impairment // Med. Hypotheses. – 2007; 68 (1): 194–6.
  10. Post R. The role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications // J. Psychiatr. Res. – 2007; 41: 979–90.
  11. Dubinina E.E., Schedrina L.E. Okislitel'nyj stress: obschie ponjatija ob aktivnyh formah kisloroda i komponentah antioksidantnoj sistemy. Okislitel'nyj stress v psihiatrii i nevrologii / SPb: 2016; s. 15–58.
  12. Liochev S. Reactive oxygen species and the free radical theory of aging // Free Radical Biology and Medicine. – 2013; 60: 1–4.
  13. Hacioglu G., Senturk A., Ince I. et al. Assessment of oxidative stress parameters of brain-derived neurotrophic factor heterozygous mice in acute stress model // Iranian J. Basic Med. Sci. – 2016; 19 (4): 388–93.
  14. Anikumar P., Alvin T., Sahebarao M. Differential effects of long-term treatment with typical and atypical antipsychotics on NGF and BDNF levels in rat striatum and hippocampus // Schizophrenia Research. – 2006; 82 (1): 95–106.
  15. Chen C., Huang T. Effects of antipsychotics on the serum BDNF levels in schizophrenia // Psychiatry Res. – 2011; 189 (3): 327–30.