VASCULAR COGNITIVE IMPAIRMENT: FROM PATHOGENESIS TO TREATMENT

Download full text PDF
Issue: 
6
Year: 
2017

Professor O. Tkacheva, MD; Professor N. Runikhina, MD; M. Cherdak, Candidate of Medical Sciences Russian Gerontology Research and Clinical Center, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow

The term vascular cognitive impairments (VCI) defines dementia and cognitive impairment no dementia, which are pathogenetically associated with cerebral vessel damage. The paper considers the etiology, pathogenesis, criteria for instrumental and clinical diagnosis, as well as VCI. The relationship between VCI and neurodegenerative diseases is discussed separately.

Keywords: 
gerontology
cerebrovascular diseases
vascular cognitive impairment
Alzheimer’s disease



It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Hachinski V. Stroke: a global agenda (Victor and Clara Soriano Award Lecture) // J. Neurol. Sci. – 2009; 285: 1–4.
  2. Jellinger K. Morphologic diagnosis of «vascular dementia» – a critical update. // J. Neurol. Sci. – 2008; 270: 1–12.
  3. Sachdev P., Kalaria R., O’Brien J. et al. Diagnostic criteria for vascular cognitive disorders: a VASCOG statement // Alz. Dis. Ass. Dis. – 2014; 28: 206–18.
  4. Lim J., Kwon H. Risk of «silent stroke» in patients older than 60 years: risk assessment and clinical perspectives // Clin. Interv. Aging. – 2010; 5: 239–51.
  5. Cherdak M.A., Jahno N.N. Nejrodegenerativnye i sosudistye faktory razvitija postinsul'tnyh kognitivnyh rasstrojstv // Nevrol. zhurn. – 2012; 17 (5): 10–5.
  6. Fonjakin A.V, Geraskina L.A. Arterial'naja rigidnost', endotelial'naja funktsija i tserebrovaskuljarnye zabolevanija // Spravochnik poliklinicheskogo vracha. – 2014; 4: 22–5.
  7. van Sloten T., Stehouwer C. Carotid stiffness: a novel cerebrovascular disease risk factor // Pulse (Basel). – 2016; 4: 24–7.
  8. Gorelick P., Scuteri A., Black S. et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American heart association/American stroke association // Stroke. – 2011; 42 (9): 2672–713.
  9. Farrall A., Wardlaw J. Blood-brain barrier: Ageing and microvascular disease – systematic review and meta-analysis // Neurobiol. Aging. – 2009; 30: 337–52.
  10. Hilal S., Sikking E., Shaik M. Cortical cerebral microinfarcts on 3T MRI: A novel marker of cerebrovascular disease // Neurology. – 2016; 87 (15): 1583–90.
  11. Daulatzai M. Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease // J. Neurosci. Res. – 2016; 95 (4): 943–72.
  12. Mhitarjan E.A., Preobrazhenskaja I.S. Bolezn' Al'tsgejmera i tserebrovaskuljarnye rasstrojstva // Nevrol. zhurn. – 2006; 11 (1): 31–6.
  13. Cherdak M.A., Uspenskaja O.V. Sosudistaja dementsija // Nevrol., nejropsihiat., psihosomat. – 2010; 1: 30–6.
  14. Mhitarjan E.A. Znachenie sosudistyh tserebral'nyh narushenij pri bolezni Al'tsgejmera. Dis. ... kand. med. nauk / M., 2004.
  15. Matsui T., Nemoto M., Maruyama M. Plasma homocysteine and risk of coexisting silent brain infarction in Alzheimer's disease // Neurodegener. Dis. – 2005; 2 (6): 299–304.
  16. Harrison S., Tang E., Keage H. et al. A systematic review of the definitions of vascular cognitive impairment, no dementia in cohort studies // Dement. Geriatr. Cogn. Disord. – 2016; 42 (1–2): 69–79.
  17. DeKosky S., Williamson J., Fitzpatrick A. et al. Ginkgo biloba for prevention of dementia. A randomized controlled trial // JAMA. – 2008; 300: 2253–62.
  18. Baskys A., Hou A. Vascular dementia: pharmacological treatment approaches and perspectives // Clin. Interv. Aging. – 2007; 2 (3): 327–35.
  19. Kavirajan H., Schneider L. Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials // Lancet Neurol. – 2007; 6 (9): 782–92.
  20. Xi Y., Wang M., Zhang W. et al. Neuronal damage, central cholinergic dysfunction and oxidative damage correlate with cognitive deficits in rats with chronic cerebral hypoperfusion // Neurobiol. Learn. Mem. – 2014; 109: 7–19.
  21. Rammes G., Rupprecht R., Ferrari U. The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner // Neurosci. Lett. – 2001; 306: 81–4.
  22. Voznesenskaja T.G. Emotsional'no-affektivnye i povedencheskie narushenija pri legkih i umerennyh kognitivnyh rasstrojstvah. Opyt primenenija memantina // Nevrol. zhurn. – 2009; 14 (3): 49–55.