THE MECHANISM OF THYROID HORMONE ACTION ON CHOLESTEROL METABOLISM

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Issue: 
5
Year: 
2017

E. Popova (1), Candidate of Medical Sciences; A. Tinkov (1), 2, Candidate of Medical Sciences; A. Yakubovskaya (1); Professor A. Nikonorov (1), MD 1-Orenburg State Medical University 2-P.G. Demidov Yaroslavl State University

The paper describes the main mechanisms of thyroid hormone actions on cholesterol metabolism and indicates the possible causes of dyslipidemia in patients with hypothyroidism.

Keywords: 
thyroid hormones
thyroid hormone receptors
deiodinases
cross reaction
cholesterol metabolism
lipoprotein metabolism



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References: 
  1. Rizos C., Elisaf M., Liberopoulos E. Effects of Thyroid Dysfunction on Lipid Profile // Open Cardiovasc. Med. J. – 2011; 5: 76–84.
  2. Mullur R., Liu Y., Brent G. Thyroid hormone regulation of metabolism // Rhysiol. Rev. – 2014; 94: 355–82.
  3. Cheng S., Leonard J., Davis R. Molecular asrects of thyroid hormone actions // Endocr. Rev. – 2010; 31 (2): 139–70.
  4. Liu Y., Brent G. Thyroid hormone crosstalk with nuclear signaling in metabolic regulation // Trends Endocrinol. Metab. – 2010; 21: 166–73.
  5. Considine R. Thyroid hormone, Synthesis, Secretion and Metabolism. Medical physiology: Principles for Clinical Medicine. Fourth Edition, edited by R. Rhoades, D. Bell: Wolters Kluwer / Lippincott Williams and Wilkins, 2013; 626 p.
  6. Di Cosmo C., Liao X., Dumitrescu A. et al. Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion // J. Clin. Invest. – 2010; 120 (9): 3377–88.
  7. Mayerl S., Visser T., Darras V. et al. Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain // Endocrinology. – 2012; 153 (3): 1528–37.
  8. Gereben B., Zavacki A., Ribich S. et al. Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling // Endocr. Rev. – 2008; 29 (7): 898–938.
  9. Watanabe M., Houten S., Mataki C. et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation // Nature. – 2006; 439: 484–9.
  10. Leiria L., Dora J., Wajner S. et al. The rs225017 Polymorphism in the 3'UTR of the Human DIO2 Gene Is Associated with Increased Insulin Resistance // PLoS One. – 2014; 9 (8): e103960. DOI:10.1371/journal.pone.0103960.
  11. Simonides W., Mulcahey M., Redout E. et al. Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats // J. Clin. Invest. – 2008; 118: 975–83.
  12. Brent G. Mechanism of thyroid hormone action // J. Clin. Invest. – 2012; 122 (9): 3035–43.
  13. Semenza G. Defining the role of hypoxia-inducible factor 1 in cancer biology andtherapeutics // Oncogene. – 2010; 29: 625–34.
  14. Ruderman N., Carling D., Prentki M. et al. AMPK, insulin resistance, and themetabolic syndrome // J. Clin. Invest. – 2013; 123: 2764–71.
  15. Faure P., Oziol L., Artur Y. et al. Thyroid hormone (T3) and its acetic derivative (TA3) protect low-density lipoproteins from oxidation by different mechanisms // Biochimie. – 2004; 86: 411–8.
  16. Duntas L. Thyroid disease and lipids // Thyroid. – 2002; 2 (4): 287–93.
  17. Mushtaq S., Sheikh I., Rashid T. et al. Dyslipidemia in Thyroid Disorders // Indo Am. J. Pharmac. Res. – 2015; 5 (11): 3439–43.
  18. Kahaly G. Cardiovascular and Atherogenic Aspects of Subclinical Hypothyroidism // Thyroid. – 2000; 10 (8): 665–79.
  19. Diez J., Iglesias P. Serum cholesterol and triglyceride levels in diabetic patients with subclinical hypothyroidism // Orig. Res. Ar. Endocrinologia y Nutrición (English Edition). – 2014; 61 (8): 419–25.