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PATHOGENESIS, PREVENTION, AND MANAGEMENT OF PATIENTS WITH ANEMIA OCCURRING DURING ANTIVIRAL THERAPY WITH BOCEPREVIR FOR CHRONIC HEPATITIS C

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Issue: 
7
Year: 
2015

E. Burnevich (1–3), Candidate of Medical Sciences; N. Tikhonova (4) 1 -I.M. Sechenov First Moscow State Medical University 2 -Department of Health-Promotion Technologies, Research Center, I.M. Sechenov First Moscow State Medical University 3 -City Clinical Hospital Twenty Four, Moscow Healthcare Department 4 -M.V. Lomonosov Moscow State University

Current triple antiviral therapy for chronic hepatitis C, by using the first wave, first-generation hepatitis C virus protease inhibitor boceprevir, results in the higher incidence of anemia, including severe one, than dual therapy with pegylated interferon and ribavirin; moreover, the hemoglobin reduction is more marked and occurs earlier. The paper deals with the present views of the pathogenesis of anemia; its risk factors; today’s optimal approaches to its prediction, prevention, and management of patients with chronic hepatitis C who receive triple antiviral therapy using boceprevir.

Keywords: 
chronic hepatitis C
antiviral therapy
first wave
first-generation protease inhibitor
boceprevir
anemia
erythropoietin
ribavirin dose reduction



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