PATHOGENETICALLY TARGETED THERAPY FOR GASTROESOPHAGEAL REFLUX DISEASE
Issue:
1
Year:
2015
The paper provides evidence that pathogenetically targeted therapy with a combination of a proton pump inhibitor and an alginate (Gaviscon® Double Action) should be used in gastroesophageal reflux disease.
Keywords:
Gaviscon® Double Action
proton pump inhibitor
clinical
endoscopic
and histological remission
References:
- Starostin B.D. Gastroezofageal'naja refljuksnaja bolezn' (chast' I). Epidemiologija, faktory riska // Gastroenterologija Sankt-Peterburga. – 2014; 1–2: 2–14.
- Kahrilas P. Gastroesophageal reflux disease // JAMA. – 1996; 276: 983–8.
- Starostin B.D. Gastroezofageal'naja refljuksnaja bolezn' // Rus. med. zhurn. – 1997; 5 (2): 72–80.
- Isakov V.A., Morozov S.V., Stavraki E.S. i dr. Analiz rasprostranennosti izzhogi: natsional'noe epidemiologicheskoe issledovanie vzroslogogorodskogo naselenija (ARIADNA) // Eksper. i klin. gastroenterol. – 2008; 1:20–9.
- Lazebnik L.B., Masharova A.A., Bordin D.S. i dr. Rezul'taty mnogotsen trovogo issledovanija «Epidemiologija gastroezofageal'noj refljuksnoj bolezni v Rossii» (MEGRE) // Ter. arh. – 2011; 16: 45–50.
- Starostin B.D. Gastroezofageal'naja refljuksnaja bolezn' (chast' II). Etiopatogenez, klinika, diagnostika // Gastroenterologija Sankt-Peterburga. – 2014; 3–4: 2–14.
- Tytgat G., McColl K., Tack J. et al. New algorithm for the treatment of gastrooesophageal reflux disease // Aliment. Pharmacol. Ther. – 2008; 27: 249–56.
- Fletcher J. et al. Unbuffered Highly Acidic Gastric Juice Exists at the Gastroesophageal Junction After a Meal // Gastroenterology. – 2001; 121: 775– 83.
- Beamont H., Bennink R., de Jong J. et al. The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD // Gut. – 2010; 59 (4): 441–51.
- Namasiovayam V., Katzka D. Extraesophageal reflux Definition and Pathophysiology. In: AJ DiMarino Jr, S. Cohen, ed. Extraesophageal Manifestations of GERD. Slack Incorporated, 2013; 1–19.
- Clarke A., Wirz A., Manning J. et al. Severe reflux disease is associated with an enlarged unbuffered proximal gastric acid pocket // Gut. – 2008; 57: 292–7.
- Pandolfino J. et al. Acidity Surrounding the Squamocolumnar Junction in GERD Patients: «Acid Pocket» Versus «Acid Film» // Am. J. Gastroenterol. – 2007; 102: 263–4.
- Kahrilas P. et al. The Acid Pocket: A Target for Treatment in Reflux Disease? // Am. J. Gastroenterol. – 2013; 108: 1058–64.
- Beaumont H., Boeckxstaens G. Scintigraphic imaging of the acid pocket: an enlarged pocket with acid coating the distal esophagus in GERD patients with hiatal hernia. 2009.
- Kahrilas P., Boeckxstaens G., Smout A. Management of the patient with incomplete response to PPI therapy // Best Practice & Res. Clin. Gastroenterol. – 2013; 27: 401–14.
- Manabe N., Haruma K., Ito M. et al. Efficacy of adding sodium alginate to omeprazole in patients with nonerosive reflux disease: a randomized clinical trial // Dis. Esophagus. – 2012; 25: 373–80.
- Chiu C.-T. et al. Randomised clinical trial: sodium alginate oral suspension is non-inferior to omeprazole in the treatment of patients with non-erosive gastroesophageal disease // Aliment. Pharmacol. Ther. – 2013; 38 (9): 1054–64.
- Wang Y.-K. et al. Current Pharmacological Management of Gastroesophageal Reflux Disease // Gastroenterol Res. Pract. – 2013; http://dx.doi. org/10.1155/2013/983653
- Boeckxstaens G. et al. Symptomatic reflux disease: the present, the past and the future // Gut. – 2014; 63: 1185–93.