Коморбидная патология у детей с расстройствами аутистического спектра

DOI: https://doi.org/10.29296/25877305-2021-08-09
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Номер журнала: 
8
Год издания: 
2021

Л.Н. Чернова, Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет) E-mail:
doctorlyubov@rambler.ru

Расстройства аутистического спектра (РАС) представляют собой чрезвычайно гетерогенную группу нарушений нервно-психического развития многофакторного генеза. Детям с РАС необходимо всестороннее наблюдение педиатра и специалистов из других областей медицины в связи с наличием коморбидной патологии, к которой относятся как соматические (частые респираторные болезни, аллергические проявления, констипация, диарея), так и неврологические симптомы (нарушения сна, гиперактивность, дефицит внимания, судороги). Проблема сбора информации о соматической патологии у детей с РАС, в первую очередь, связана с трудностями осмотра, недостаточным социальным взаимодействием в силу таких причин, как невозможность охарактеризовать и локализовать собственные ощущения (в том числе, болевые), что нередко ошибочно относят к неврологическим симптомам, связанным с основным заболеванием.
Ключевые слова: 
педиатрия
дети
расстройства аутистического спектра
коморбидная патология
Для цитирования
Л.Н. Чернова Коморбидная патология у детей с расстройствами аутистического спектра . Врач, 2021; (8): 50-53 https://doi.org/10.29296/25877305-2021-08-09

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Список литературы: 
  1. Schieve L.A., Gonzalez V., Boulet S.L. et al. Concurrent medical conditions and health care use and needs among children with learning and behavioral developmental disabilities, National Health Interview Survey, 2006–2010. Res Dev Disabil. 2012; 33 (2): 467–76. DOI: 10.1016/j.ridd.2011.10.008
  2. Muskens J.B., Velders F.P., Staal W.G. Medical comorbidities in children and adolescents with autism spectrum disorders and attention deficit hyperactivity disorders: a systematic review. Eur Child Adolesc Psychiatry. 2017; 26 (9): 1093–103. DOI: 10.1007/s00787-017-1020-0
  3. Aldinger K.A., Lane C.J., Veenstra-VanderWeele J. et al. Patterns of risk for multiple co-occurring medical conditions replicate across distinct cohorts of children with Autism Spectrum Disorder. Autism Res. 2015; 8 (6): 771–81. DOI: 10.1002/aur.1492
  4. Buie T., Campbell D.B., Fuchs G.J. 3rd et al. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics. 2010; 125 (Suppl. 1): S1–S18. DOI: 10.1542/ peds.2009-1878C
  5. Wang L.W., Tancredi D.J., Thomas D.W. The prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members. J Dev Behav Pediatr. 2011; 32 (5): 351–60. DOI: 10.1097/DBP.0b013e31821bd06a
  6. Gesundheit B., Rosenzweig J.P., Naor D. et al. Immunological and autoimmune considerations of Autism Spectrum Disorders. J Autoimmun. 2013; 44: 1–7. DOI: 10.1016/j.jaut.2013.05.005
  7. Xu G., Snetselaar L.G., Jing J. et al. Association of Food Allergy and Other Allergic Conditions With Autism Spectrum Disorder in Children. JAMA Netw Open. 201; 1 (2): e180279. DOI: 10.1001/jamanetworkopen.2018.0279
  8. Souders M.C., Mason T.B., Valladares O. et al. Sleep behaviors and sleep quality in children with autism spectrum disorders. Sleep. 2009; 32 (12): 1566–78. DOI: 10.1093/sleep/32.12.1566
  9. Niemczyk J., Wagner C., von Gontard A. Incontinence in autism spectrum disorder: a systematic review. Eur Child Adolesc Psychiatry. 2018; 27 (12): 1523–37. DOI: 10.1007/s00787-017-1062-3
  10. Viscidi E.W., Triche E.W., Pescosolido M.F. et al. Clinical characteristics of children with autism spectrum disorder and co-occurring epilepsy. PloS One. 2013; 8 (7): e67797. DOI: 10.1371/journal.pone.0067797
  11. Leitner Y. The co-occurrence of autism and attention deficit hyperactivity disorder in children – what do we know? Front Hum Neurosci. 2014; 29; 8: 268. DOI: 10.3389/fnhum.2014.00268
  12. Chen M.H., Su T.P., Chen Y.S. et al. Is atopy in early childhood a risk factor for ADHD and ASD? A longitudinal study. J Psychosom Res. 2014; 77 (4): 316–21. DOI: 10.1016/j.jpsychores.2014.06.006
  13. Li H., Liu H., Chen X. et al. Association of food hypersensitivity in children with the risk of autism spectrum disorder: a meta-analysis. Eur J Pediatr. 2021; 180 (4): 999–1008. DOI: 10.1007/s00431-020-03826-x
  14. Sabourin K.R., Reynolds A., Schendel D. et al. Infections in children with autism spectrum disorder: Study to Explore Early Development (SEED). Autism Res. 2019; 12 (1): 136–46. DOI: 10.1002/aur.2012
  15. Goodwin M.S., Cowen M.A., Goodwin T.C. Malabsorption and cerebral dysfunction: a multivariate and comparative study of autistic children. J Autism Child Schizophr. 1971; 1 (1): 48–62. DOI: 10.1007/BF01537742
  16. McElhanon B.O., McCracken C., Karpen S. et al. Gastrointestinal symptoms in autism spectrum disorder: a meta-analysis. Pediatrics. 2014; 133 (5): 872–83. DOI: 10.1542/peds.2013-3995
  17. Adams J.B., Johansen L.J., Powell L.D. et al. Gastrointestinal flora and gastrointestinal status in children with autism--comparisons to typical children and correlation with autism severity. BMC Gastroenterol. 2011; 11: 22. DOI: 10.1186/1471-230X-11-22
  18. Page S.D., Souders M.C., Kral T.V.E. et al. Correlates of Feeding Difficulties Among Children with Autism Spectrum Disorder: A Systematic Review. J Autism Dev Disord. 2021; Mar 5. DOI: 10.1007/s10803-021-04947-4
  19. Coury D., Jones N.E., Klatka K. et al. Healthcare for children with autism: the Autism Treatment Network. Curr Opin Pediatr. 2009; 21 (6): 828–32. DOI: 10.1097/MOP.0b013e328331eaaa
  20. Whiteley P., Haracopos D., Knivsberg A.M. et al. The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders. Nutr Neurosci. 2010; 13 (2): 87–100. DOI: 10. 1179/147683010x12611460763922
  21. Lange K.W., Hauser J., Reissmann A. Gluten-free and casein-free diets in the therapy of autism. Curr Opin Clin Nutr Metab Care. 2015; 18 (6): 572–5. DOI: 10.1097/MCO.0000000000000228
  22. Kushak R.I., Lauwers G.Y., Winter H.S. et al. Intestinal disaccharidase activity in patients with autism: effect of age, gender, and intestinal inflammation. Autism. 2011; 15 (3): 285–94. DOI: 10.1177/1362361310369142
  23. Vuong H.E., Hsiao E.Y. Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder. Biol Psychiatry. 2017; 81 (5): 411–23. DOI:10.1016/j.biopsych.2016.08.024
  24. Nikolov R.N., Bearss K.E., Lettinga J. et al. Gastrointestinal symptoms in a sample of children with pervasive developmental disorders. J Autism Dev Disord. 2009; 39 (3): 405–13. DOI: 10.1007/s10803-008-0637-8
  25. Owens J., Opipari L., Nobile C. et al. Sleep and daytime behavior in children with obstructive apnea and behavioral sleep disorders. Pediatrics. 1998; 102: 1178–84. DOI: 10.1542/peds.102.5.1178
  26. von Gontard A., Pirrung M., Niemczyk J. et al. Incontinence in children with autism spectrum disorder. J Pediatr Urol. 2015; 11 (5): 264.e261–267. DOI: 10.1016/j.jpurol.2015.04.015
  27. Gillberg C. The treatment of epilepsy in autism. Autism Dev Disord. 1991; 21 (1): 61–77. DOI: 10.1007/BF02206998
  28. McCue L.M., Flick L.H., Twyman K.A. et al. Prevalence of non-febrile seizures in children with idiopathic autism spectrum disorder and their unaffected siblings: a retrospective cohort study. BMC Neurol. 2016; 16 (1): 245. DOI: 10.1186/s12883-016-0764-3
  29. Bauman M.L. Medical comorbidities in autism: challenges to diagnosis and treatment. NeuroRx. 2010; 7 (3): 320–7. DOI: 10.1016/j.nurt.2010.06.001