Дислипидемии: эпидемиология, клиника, диагностика, профилактика и лечение
DOI: https://doi.org/10.29296/25877305-2021-05-03
Номер журнала:
5
Год издания:
2021
В статье с позиций медицинской профилактики раскрыта проблема дислипидемий как фактора риска
неинфекционных заболеваний, дано их определение. Описаны роль холестерина в функционировании организма и его
метаболизм. Перечислены группы скрининга на гиперхолестеринемию, отмечены факторы риска развития
дислипидемий. Дано краткое описание основных средств, используемых для лечения данной патологии, при этом
акцент сделан на использовании целевых функциональных пищевых продуктов. В заключении даны рекомендации по
коммуникации проблемы дислипидемии с пациентами.
Ключевые слова:
эндокринология
дислипидемии
гиперхолестеринемия
медицинская профилактика
функциональные пищевые продукты
Для цитирования
К.Р. Амлаев Дислипидемии: эпидемиология, клиника, диагностика, профилактика и лечение
. Врач, 2021; (5): 16-20 https://doi.org/10.29296/25877305-2021-05-03Список литературы:
- Kopin L., Lowenstein C. Dyslipidemia. Ann Intern Med. 2017; 167 (11): ITC81–ITC96. DOI: 10.7326/AITC201712050
- Bamba V. Update on screening, etiology, and treatment of dyslipidemia in children. JCEM. 2014; 99: 3093–102. DOI: 10.1210/jc.2013-3860
- Eckel R.H., Jakicic J.M., Ard J.D. et al. 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk: A Report of the American College of Cardiology. American Heart Association Task Force on Practice Guidelines. Circulation. 2014; 129: S76–S99. DOI: 10.1161/01.cir.0000437740.48606.d1
- Carroll M.D., Fryer C.D., Nguyen D.T. High Total and Low High-Density Lipoprotein Cholesterol in Adults: United States, 2015–2016; NCHS Data Brief, No 290; National Center for Health Statistics: Hyattsville, MD, USA, 2017.
- Nicholls S., Lundman P. The emerging role of lipoproteins in atherogenesis: beyond LDL cholesterol. Semin Vasc Med. 2004; 4: 187–95. DOI: 10.1055/s-2004-835377
- Mozaffarian D., Benjamin E.J., Go A.S. et al. Writing Group Members. Executive Summary: Heart Disease and Stroke Statistics – 2016 Update: A Report from the American Heart Association. Circulation. 2016; 133: 447–54. DOI: 10.1161/CIR.0000000000000366
- Centers for Disease Control and Prevention (CDC). Vital signs: prevalence, treatment, and control of high levels of low-density lipoprotein cholesterol – United States, 1999–2002 and 2005–2008. MMWR Morb Mortal Wkly Rep. 2011; 60 (4): 109–14.
- Гриценко Т.А., Косякова Ю.А., Давыдкин И.Л. и др. Болезни крови в амбулаторной практике. Под ред. И.Л. Давыдкина. М.: ГЭОТАР-Медиа, 2020; 272 с. [Gritsenko T.A., Kosyakova Yu.A., Davydkin I.L. et al. Bolezni krovi v ambulatornoi praktike. Pod red. I.L. Davydkina. M.: GEOTAR-Media, 2020; 272 s. (in Russ.)]. DOI: 10/33029/9704-5916-4-НЕМ-2020-1-272
- The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). Eur Heart J. 2012; 33 (13): 1635–701. DOI: 10.1093/eurheartj/ehs092
- 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias. The Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS). Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Atherosclerosis. 2016; 253: 281–344. DOI: 10.1016/j.atherosclerosis.2016.08.018
- Goldstein J.L., Brown M.S. A century of cholesterol and coronaries: from plaques to genes to statins. Cell. 2015; 161 (1): 161–72. DOI: 10.1016/j.cell.2015.01.036
- Grundy S.M., Cleeman J.I., Merz C.N. et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. J Am Coll Cardiol. 2004; 44: 720–32. DOI: 10.1016/j.jacc.2004.07.001
- Smith S.C. Jr., Allen J., Blair S.N., Bonow R.O. et al. AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute. Circulation. 2006; 113: 2363–72. DOI: 10.1161/CIRCULATIONAHA.106.174516
- Grundy S.M., Cleeman J.I., Merz C.N. et al.Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation. 2004; 110: 227–39. DOI: 10.1161/01.CIR.0000133317.49796.0E
- Lipoprotein Metabolism and Cholesterol Balance. In: Arias I.M., Alter H.J., Boyer J.L., Cohen D.E., Fausto N., Shafritz D.A., Wolkoff A.W. (eds.). The Liver: Biology and Pathobiology. 5th Ed. West Sussex: Wiley-Blackwell, 2009; p. 271–85.
- Portincasa P., Moschetta A., Di Ciaula A. et al. Pathophysiology and Cholesterol Gallstone Disease. In: Borzellino G., Cordiano C. (eds.). Biliary Lithiasis: Basic Science, Current Diagnosis and Manage- ment. 1st Ed. Milano: Springer Italia; S.r.l., 2008; p. 19–49.
- Grouleff J., Irudayam S.J., Skeby K.K. et al. The influence of cholesterol on membrane protein structure, function, and dynamics studied by molecular dynamics simulations. BBA Biomembr. 2015; 1848: 1783–95. DOI: 10.1016/j.bbamem.2015.03.029
- Yang S.-T., Kreutzberger A.J.B., Lee J. et al. The role of cholesterol in membrane fusion. Chem Phys Lipids. 2016; 199: 136–43. DOI: 10.1016/j.chemphyslip.2016.05.003
- Rogers M.A., Liu J., Song B.-L. et al. Acyl-CoA: cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators. J Steroid Biochem Mol Biol. 2015; 151: 102–7. DOI: 10.1016/j.jsbmb.2014.09.008
- Christie M.P., Johnstone B.A., Tweten R.K. et al. Cholesterol-dependent cytolysins: From water-soluble state to membrane pore. Biophys Rev. 2018; 10 (5): 1337–48. DOI: 10.1007/s12551-018-0448-x
- Gao Y., Zhou Y., Goldstein J.L. et al. Cholesterol-induced conformational changes in the sterolsensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis. J Biol Chem. 2017; 292: 8729–37. DOI: 10.1074/jbc.M117.783894
- Wang T.J. Vitamin D and Cardiovascular Disease. Annu Rev Med. 2016; 67: 261–72. DOI: 10.1146/annurev-med-051214-025146
- Dash S., Xiao C., Morgantini C. et al. New Insights into the Regulation of Chylomicron Production. Annu Rev Nutr. 2015; 35: 265–94. DOI: 10.1146/annurev-nutr-071714-034338
- Julve J., Martin-Campos J.M., Escolà-Gil J.C. et al. Chylomicrons: Advances in biology, pathology, laboratory testing, and therapeutics. Clin Chim Acta. 2016; 455: 134–48. DOI: 10.1016/j.cca.2016.02.004
- Wolska A., Dunbar R.L., Freeman L.A. et al. Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism. Atherosclerosis. 2017; 267: 49–60. DOI: 10.1016/j.atherosclerosis.2017.10.025
- Doonan L.M., Fisher E.A., Brodsky J.L. Can modulators of apolipoproteinB biogenesis serve as an alternate target for cholesterol-lowering drugs? BBA Mol Cell Biol Lipids. 2018; 1863: 762–71. DOI: 10.1016/j.bbalip.2018.03.010
- Tiwari S., Siddiqi S.A. Intracellular trafficking and secretion of VLDL. Arterioscler Thromb Vasc Biol. 2012; 32: 1079–86. DOI: 10.1161/ATVBAHA.111.241471
- Nassir F., Adewole O.L., Brunt E.M. et al. CD36 deletion reduces VLDL secretion, modulates liver prostaglandins, and exacerbates hepatic steatosis in ob/ob mice. J Lipid Res. 2013; 54: 2988–97. DOI: 10.1194/jlr.M037812
- Etxebarria A., Benito-Vicente A., Stef M. et al. Activity-associated effect of LDL receptor missense variants located in the cysteine-rich repeats. Atherosclerosis. 2015; 238: 304–12. DOI: 10.1016/j.atherosclerosis.2014.12.026
- Do R., Willer C.J., Schmidt E.M. et al.Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet. 2013; 45: 1345–52. DOI: 10.1038/ng.2795
- Kotwal S., Jun M., Sullivan D. et al. Omega 3 fatty acids and cardiovascular outcomes: systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes. 2012; 5: 808–18. DOI: 10.1161/CIRCOUTCOMES.112.966168
- Wang H.H., Garruti G., Liu M. et al. Cholesterol and Lipoprotein Metabolism and Atherosclerosis: Recent Advances in Reverse Cholesterol Transport. Ann Hepatol. 2017; 16 (Suppl. 1): S27–S42. DOI: 10.5604/01.3001.0010.5495
- Rashid S., Genest J. Effect of obesity on high-density lipoprotein metabolism. Obesity. 2012; 15: 2875–88. DOI: 10.1038/oby.2007.342
- Navarro E., Mijac V., Ryder H.F. Ultrasonography measurement of intrabdominal visceral fat in obese men. Association with alterations in serum lipids and insulinemia. Arch Latinoam Nutr. 2010; 60: 160–7.
- Rashid S., Uffelman K.D., Lewis G.F. The mechanism of HDL lowering in hypertriglyceridemic, insulin-resistant states. J Diabetes Complicat. 2002; 16: 24–8. DOI: 10.1016/s1056-8727(01)00191-x
- Schwartz G.G., Olsson A.G., Abt M., et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. NEJM. 2012; 367: 2089–99. DOI: 10.1056/NEJMoa1206797
- Rader D.J., Hovingh G.K. HDL and cardiovascular disease. Lancet. 2014; 384: 618–25. DOI: 10.1016/S0140-6736(14)61217-4
- Pitha J., Kovar J., Blahova T. Fasting and nonfasting triglycerides in cardiovascular and other diseases. Physiol Res. 2015; 64 (Suppl. 3): S323–30. DOI: 10.33549/physiolres.933196
- U.S. Preventive Services Task Force. Final Update Summary: Lipid Disorders in Adults (Cholesterol, Dyslipidemia): Screening. July 2015. Accessed at www.uspreventiveservices taskforce.org
- Karr S. Epidemiology and management of hyperlipidemia. Am J Manag Care. 2017; 23: S139–S148.
- Mozaffarian D., Benjamin E.J., Go A.S. et al. Heart disease and stroke statistics – 2016 update: a report from the American Heart Association. Circulation. 2016; 133 (4): e38–e360. DOI: 10.1161/CIR.0000000000000350.
- Raal F.J., Pilcher G.J., Panz V.R. et al. Reduction in mortality in subjects with homozygous familial hyper-cholesterolemia associated with advances in lipid-lowering therapy. Circulation. 2011; 124 (20): 2202–7. DOI: 10.1161/circulationaha.111.042523
- Stone N.J., Robinson J.G., Lichtenstein A.H. et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults. J Am Coll Cardiol. 2014; 63 (25): 2889–934. DOI: 10.1016/j.jacc.2013.11.002
- Marais A.D. Familial hypercholesterolaemia. Clin Biochem Rev. 2004; 25: 49.
- Oliva C.P., Pisciotta L., Volti G.L. et al. Inherited apolipoprotein AV deficiency in severe hypertriglyceridemia. Arterioscler Thromb Vasc Biol. 2005; 25: 411–7. DOI: 10.1161/01.ATV.0000153087.36428.dd
- Hannon B.A., Khan N.A., Teran-Garcia M. Nutrigenetic Contributions to Dyslipidemia: A Focus on Physiologically Relevant Pathways of Lipid and Lipoprotein Metabolism. Nutrients. 2018; 10 (10): 1404. DOI: 10.3390/nu10101404
- Stone N.J., Robinson J.G., Lichtenstein A.H. et al. American College of Cardiology/American Heart Association Task Force on Practice Guide- lines. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology / American Heart Association Task Force on Practice Guidelines. Circulation. 2014; 129: S1–45. DOI: 10.1161/01.cir.0000437738.63853.7a
- Benito-Vicente A., Uribe K.B., Jebari S. et al. Familial Hypercholesterolemia: The Most Frequent Cholesterol Metabolism Disorder Caused Disease. Int J Mol Sci. 2018; 19 (11): 3426. DOI: 10.3390/ijms19113426
- de Lorgeril M., Salen P., Martin J.L. et al. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation. 1999; 99: 779–85. DOI: 10.1161/01.cir.99.6.779
- Eckel R.H., Jakicic J.M., Ard J.D. et al. American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 AHA/ ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology / American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014; 63: 2960–84. DOI: 10.1016/j.jacc.2013.11.003
- 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020; 41: 111–88. DOI: 10.1093/eurheartj/ehz455
- Yamashita S., Masuda D., Matsuzawa Y. Pemafibrate, a New Selective PPARα Modulator: Drug Concept and Its Clinical Applications for Dyslipidemia and Metabolic Diseases. Curr Atheroscler Rep. 2020; 22 (1): 5. DOI: 10.1007/s11883-020-0823-5
- Masuda D., Yamashita S. Postprandial Hyperlipidemia and Remnant Lipoproteins. J Atheroscler Thromb. 2017; 24 (2): 95–109. DOI: 10.5551/jat.RV16003