The role of diabetes mellitus and a gender factor in the development of a second noncardioembolic ischemic stroke
DOI: https://doi.org/10.29296/25877305-2020-10-09
Issue:
10
Year:
2020
Objective. To analyze the frequency and date of onset of a secondary noncardioembolic ischemic
stroke (IS) over a three-year period according to a patient’s gender and the presence of diabetes mellitus
(DM). Subjects and methods. The cohort observational study covered 206 patients who had experienced a first
noncardioembolic IS. The clinical and metabolic parameters were studied in the participants, as well as the
frequency and date of onset of a secondary IS were assessed using the Cutler-Ederer and Kaplan-Meier methods
according to gender and DM. Results. The analysis of the frequency and date of onset of a second
noncardioembolic IS over a three-year period showed an increase in the risk of this pathology in both male
patients and type 2 diabetes (T2DM) ones. Conclusion. Male patients and T2DM ones are at a high risk for a
secondary noncardioembolic IS.
Keywords:
neurology
endocrinology
non-cardioembolic ischemic stroke
diabetes mellitus
male sex
References:
- Stahovskaja L.V., Kotov S.V., Isakova E.V. Insul't: rukovodstvo dlja vrachej. M.: OOO «Meditsinskoe informatsionnoe agentstvo», 2013; 400 s. [Stakhovskaya L.V., Kotov S.V., Isakova E.V. Insul’t: rukovodstvo dlya vrachei. M.: OOO «Meditsinskoe informatsionnoe agentstvo», 2013; 400 s. (in Russ.)].
- Hewitt J., Castilla G.L., Fernández-Moreno M.C. et al. Diabetes and stroke prevention: a review. Stroke Res Treat. 2012; 2012: 673187. DOI: 10.1155/2012/673187
- Gibson C.L. Cerebral ischemic stroke: is gender important? J Cereb Blood Flow Metab. 2013; 33 (9): 1355–61. DOI: 10.1038/jcbfm.2013.102
- Giralt D., Domingues-Montanari S., Mendioroz M. et al. The gender gap in stroke: a meta-analysis. Acta Neurol Scand. 2012; 125 (2): 83–90. DOI: 10.1111/j.1600-0404.2011.01514.x
- Shishkova V.N., Adasheva T.V., Remennik A.Ju. i dr. Prognosticheskaja znachimost' kliniko-antropometricheskih, biohimicheskih, metabolicheskih, sosudisto-vospalitel'nyh i molekuljarno-geneticheskih markerov v razvitii pervogo ishemicheskogo insul'ta. Zhurnal nevrol. i psihiatr. im. S.S. Korsakova. 2018; 118 (2): 4–11 [Shishkova V.N., Adasheva T.V., Remenik A.Yu. et al. Prognostic significance of clinical-anthropometric, biochemical, metabolic, vascular-inflammatory and molecular-genetic markers in the development of the first ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2018; 118 (2): 4–11 (in Russ.)]. https://doi.org/10.17116/jnevro2018118214-11
- Chen R., Ovbiagele B., Feng W. Diabetes and stroke: epidemiology, pathophysiology, pharmaceuticals and outcomes. Am J Med Sci. 2016; 351 (4): 380–6. DOI: 10.1016/j.amjms.2016.01.011