THE RARE SIDE EFFECT OF BOTULINUM THERAPY IS A VASOSPASTIC REACTION AT THE INJECTION SITES
Issue:
12
Year:
2017
The paper describes a rare clinical case of a vasospastic reaction after injection of botulinum toxin type A (BT-A) into the forehead and glabella, as aesthetically indicated. It analyzes the data available in the literature, which describe similar cases, and discusses the possible mechanisms underlying the action of BT-A on vascular tone.
Keywords:
aesthetic medicine
botulinum toxin A
facial vessels
blanching effect
acetylcholine
References:
- https://www.surgery.org/sites/default/files/ASAPS-Stats2016.pdf
- de Almeida H. Jr., Henkin C., Milman L. et al. Localized flushing absence after abobotulinum toxin A cosmetic treatment // Eur. J. Dermatol. – 2013; 23 (5): 714–5.
- Warren D., Woody M., Vickers J. Facial Blanching After Cosmetic Botulinum Toxin Injection: Case Series // Skinmed. – 2016; 14 (3): 239–40.
- Khan T., Herne K., Dayan S. et al. Facial blanching due to neurotoxins: proposed mechanisms // Dermatol. Surg. – 2013; 39 (1 Pt. 1): 24–9.
- Pomprasit M., Chintrakarn C. Treatment of Frey's syndrome with botulinum toxin // J. Med. Assoc. Thai. – 2007; 90 (11): 2397–402.
- Park K., Hyun M., Jeong S. et al. Botulinum toxin for the treatment of refractory erythema and flushing of rosacea // Dermatology. – 2015; 230 (4): 299–301.
- Odo M., Odo L., Farias R. et al. Botulinum toxin for the treatment of menopausal hot flushes: a pilot study // Dermatol. Surg. – 2011; 37 (11): 1579–83.
- Yuraitis M., Jacob C. Botulinum toxin for the treatment of facial flushing // Dermatol. Surg. – 2004; 30 (1): 102–4.
- Eshghi G., Khezrian L., Alirezaei P. Botulinum Toxin A in Treatment of Facial Flushing // Acta Med. Iran. – 2016; 54 (7): 454–7.
- Geddoa E., Matar H., Paes T. The use of botulinum toxin-A in the management of neck and anterior chest wall flushing: pilot study // Int. J. Dermatol. – 2013; 52 (12): 1547–50.
- Manhães R., Spitz M., Vasconcellos L. Botulinum toxin for treatment of Harlequin syndrome // Parkinsonism Relat. Disord. – 2016; 23: 112–3
- Low D., Hubing K., Del Coso J. et al. Mechanisms of cutaneous vasodilation during the postmenopausal hot flash // Menopause. – 2011; 18 (4): 359–65.
- Kellogg D. Jr., Pergola P., Piest K. et al. Cutaneous active vasodilation in humans is mediated by cholinergic nerve cotransmission // Circ. Res. – 1995; 77: 1222–8.
- Morris J., Jobling P., Gibbins I. Differential inhibition by botulinum neurotoxin A of cotransmitters released from autonomic vasodilator neurons // Am. J. Physiol. Heart Circ. Physiol. – 2001; 281 (5): H2124–32.
- Awan K. The therapeutic usage of botulinum toxin (Botox) in non-cosmetic head and neck conditions – An evidence based review // Saudi Pharm. J. – 2017; 25 (1): 18–24.
- Hubing K., Wingo J., Brothers R. et al. Nitric oxide synthase inhibition attenuates cutaneous vasodilation during postmenopausal hot flash episodes // Menopause. – 2010; 17 (5): 978–82.
- Reame N. Why fixing the furrow does not fix the flash: understanding hot flash biology with botulinumneurotoxin. Menopause. – 2011; 18 (4): 348–9.
- Oh Y., Lee N., Suh D. et al. A split-face study using botulinum toxin type B to decrease facial erythema index // J. Cosmet. Laser Ther. – 2011; 13 (5): 243–8.