Lipid spectrum of cell membranes and blood plasma in adolescents with recurrent cephalgia associated with arterial hypertension. Methods of correction

DOI: https://doi.org/10.29296/25877305-2024-02-08
Issue: 
2
Year: 
2024

Yu. Kostyuchenko(2); T. Potupchik(1), Сandidate of Medical Sciences; L. Evert(2, 3), MD; E. Panicheva(1), Сandidate of Medical Sciences; Yu. Dubrovsky(3); N. Loseva(3)
1-Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry
of Health of Russia
2-Federal Research Center «Krasnoyarsk Scientific Center of the Siberian Branch
of the Russian Academy of Sciences», Research Institute of Medical Problems
of the North
3-N.F. Katanov Khakass State University, Ministry of Education and Science
of Russia, Abakan

Purpose. To study the characteristics of the content of neutral lipids and phospholipid fractions in the membranes of erythrocytes and blood plasma of adolescents with cephalalgia and arterial hypertension (AH). Materials and methods. Subject of the study – adolescents 12–17 years old (boys and girls) with cephalgia and the presence of AH (main group) and without AH (comparison group). Methods: questionnaires, laboratory, statistical. Examination program: verification of the clinical form of cephalgia (episodic, chronic); assessment of the presence of AH (using percentile tables, taking into account age, gender and height percentile); determination of the concentration of neutral lipids and phospholipid fractions in blood plasma and erythrocyte membranes using thin layer chromatography. Results. Of the 64 examined adolescents – patients of the pediatric department with recurrent cephalgia, the frequent (chronic) form of cephalgia was verified in 40 (62.5%) people, AH was diagnosed in 10 (25.0%) adolescents with chronic cephalgia and in 30 (75.0%) adolescents with this form of cephalalgia AH were not identified. Features of the lipid spectrum of adolescents with a chronic form of cephalgia associated with AH included a lower concentration of total lipids and triglycerides in erythrocyte membranes, higher values of the general phospholipids/free cholesterol ratio and a smaller number of statistically significant correlations. Conclusion. The features we identified in the lipid spectrum of erythrocyte membranes and blood plasma in adolescents with a frequent (chronic) form of cephalalgia associated with AH may indicate the presence in adolescents of initial minimal changes in the biochemical status of cell membranes at the stages of development of cardiovascular pathology – hypertension and coronary heart disease.
Keywords: 
adolescents
recurrent cephalalgia
arterial hypertension
erythrocytes
neutral lipids
phospholipids
membranes
blood plasma
lipid spectrum.

References: 
  1. Abu-Arafeh I., Ozge A. Headache in children and adolescents. A case-based approach. Switzerland: Springer International Publishing. 2016.
  2. Nieswand V., Richter M., Gossrau G. Epidemiology of headache in children and adolescents – another type of pandemia. Curr Pain Headache Rep. 2020; 24 (10): 62. DOI: 10.1007/s11916-020-00892-6
  3. Gelfand A.A. Pediatric and adolescent headache. Continuum (Minneap Minn). 2018; 24 (4): 1108–36. DOI: 10.1212/CON.0000000000000638
  4. Wallach D.F.H. Plasma memranes and disease. London: Acad. Press., 1979.
  5. Скибицкая Л.И. Формирование липидной структуры клеточных мембран у детей с конституционально-экзогенным ожирением в различных регионах Сибири. Дис. … канд. мед. наук. Красноярск, 1999 [Skibitskaya L.I. Formation of the lipid structure of cell membranes in children with constitutionally exogenous obesity in various regions of Siberia. Dis. ... cand. med nauk. Krasnoyarsk, 1999 (in Russ.)].
  6. Курочкина Т.Н., Терещенко В.П., Булыгин Г.В. и др. Состояние лимфоцитарных мембран у детей препубертатного возраста здоровых и с увеличением щитовидной железы. Сибирское медицинское обозрение. 2002; 1: 8–10 [Kurochkina T.N., Tereshchenko V.P., Bulygin G.V. et al. The state of lymphocytic membranes in prepubescent healthy children and with an enlarged thyroid gland. Siberian Medical Review. 2002; 1: 8–10 (in Russ.)].
  7. Васильева Е.М., Баканов М.И., Гордеева Г.Ф. и др. Фосфолипидный состав эритроцитов при неврологических нарушениях у детей; влияние сопутствующей патологии. Медицинский научный и учебно-методический журнал. 2001; 2: 92–109 [Vasilyeva E.M., Bakanov M.I., Gordeeva G.F. et al. Phospholipid composition of erythrocytes in neurological disorders in children; the effect of concomitant pathology. Medical scientific and educational journal. 2001; 2: 92–109 (in Russ.)].
  8. Леонтьева И.В., Кисляк О.А., Александров А.А. и др. Артериальная гипертензия у детей и подростков. Клинические рекомендации. Ассоциация детских кардиологов России; Российское медицинское общество по артериальной гипертонии. 2020. [Leontieva I.V., Kislyak O.A., Alexandrov A.A. et al. Arterial hypertension in children and adolescents. Clinical recommendations. Association of Pediatric Cardiologists of Russia; Russian Medical Society for Arterial Hypertension. 2020 (in Russ.)].
  9. Международная классификация головной боли. 3-е издание. International Headache Society, 2018 [International classification of headache. 3rd edition. International Headache Society, 2018 (in Russ.)].
  10. Ростовцев В.Н., Резник Г.Е. Количественное определение липидных фракций плазмы крови. Лабораторное дело. 1982; 4: 218–21 [Rostovtsev V.N., Reznik G.E. Quantitative determination of lipid fractions of blood plasma. Laboratory business. 1982; 4: 218–21 (in Russ.)].
  11. Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ «STATISTICA» М.: Медиа Сфера, 2002. [Rebrova O.Y. Statistical analysis of medical data. Application of the STATISTICA software package M.: Media Sphere, 2002 (in Russ.)].
  12. Медведева И.В., Дороднева Е.Ф., Шоломов И.Ф. Изменения клеточных мембран под воздействием факторов питания. Клинические и популяционные аспекты. Известия Челябинского научного центра. 2001; 2: 95–100 [Medvedeva I.V., Doroneva E.F., Sholomov I.F. Changes in cell membranes under the influence of nutrition factors. Clinical and population aspects. Proceedings of the Chelyabinsk Scientific Center. 2001; 2: 95–100 (in Russ.)].
  13. Терещенко С.Ю. Клинико-патогенетическая роль структурной организации плазматических мембран при атопических заболеваниях у детей. Автореф. дис. … д-ра мед. наук. Красноярск, 2002 [Tereshchenko S.Y. The clinical and pathogenetic role of the structural organization of plasma membranes in atopic diseases in children: Avtoref. diss.. ... d-ra med. nauk. Krasnoyarsk, 2002 (in Russ.)].
  14. World Health Organization. A healthy diet sustainably produced. [Electronic resource]. URL: https://www.who.int/publications/i/item/WHO-NMH-NHD-18.12
  15. Zhong V.W., Van Horn L., Greenland P. et al. Associations of Processed Meat, Unprocessed Red Meat, Poultry, or Fish Intake With Incident Cardiovascular Disease and All-Cause Mortality. JAMA Intern Med. 2020; 180 (4): 503–12. DOI: 101001/jamainternmed.2019.6969
  16. World Health Organization. Guideline: sugars intake for adults and children. [Electronic resource]. URL: https://www.who.int/publications/i/item/9789241549028
  17. Ежов М.В., Кухарчук В.В., Сергиенко И.В. и др. Нарушения липидного обмена. Клинические рекомендации 2023. Российский кардиологический журнал. 2023; 28 (5): 5471 [Yezhov M.V., Kukharchuk V.V., Sergienko I.V. et al. Disorders of lipid metabolism. Clinical guidelines 2023. Russian Journal of Cardiology. 2023; 28 (5): 5471 (in Russ.)]. DOI: 10.15829/1560-4071-2023-5471
  18. Raad T., Griffin A., George E.S. et al. Dietary Interventions with or without Omega-3 Supplementation for the Management of Rheumatoid Arthritis: A Systematic Review. Nutrients. 2021; 13 (10): 3506. DOI: 10.3390/nu13103506
  19. Pellegrini M., Senni C., Bernabei F. et al. The Role of Nutrition and Nutritional Supplements in Ocular Surface. Diseases. Nutrients. 2020; 12 (4): 952. DOI: 10.3390/nu12040952
  20. Inguglia L., Chiaramonte M., Di Stefano V. et al. Salmo salar fish waste oil: Fatty acids composition and antibacterial activity. Peer J. 2020; 8: e9299. DOI: 10.7717/peerj.9299
  21. Puliappadamb H.M., Satpathy A.K., Mishra B.R. et al. Evaluation of the safety and efficacy of supplemental alpha-lipoic acid for the prevention of migraine in adolescents: a randomized controlled trial. J Clin Pharmacol. 2023; 63 (12): 1398–407. DOI: 10.1002/jcc.2331
  22. Молчанова О.В., Кочкаров В.И., Покровский М.В. и др. Фармакологические эффекты альфа-липоевой (тиоктовой) кислоты. Научные ведомости. Серия Медицина. Фармация. 2012; 141 (22): 24–9 [Molchanova O.V., Kochkarov V.I., Pokrovsky M.V. et al. Pharmacological effects of alpha-lipoic (thioctic) acid. Scientific bulletin. The Medicine series. Pharmacy. 2012; 141 (22): 24–9 (in Russ.)].
  23. Государственный реестр лекарственных средств [The State Register of Medicines. (in Russ.)]. URL: https://grls.minzdrav.gov.ru/Grls_View_v2.aspx?routingGuid=8c0d08fd-a828-49bd-a333-64f5f327558f
  24. Littarru G., Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol. 2007; 37 (1): 31–7. DOI: 10.1007/s12033-007-0052-y
  25. Потупчик Т.В., Веселова О.Ф., Эверт Л.С. и др. Коэнзим Q10 с Гинкго в кардиологической практике. Врач. 2017; 4: 35–9 [Potupchik T.V., Veselova O.F., Evert L.S., etc. Coenzyme Q10 with Ginkgo in cardiology practice. Vrach. 2017; 4: 35–9 (in Russ.)].