The characteristics of the hemostatic system in patients with external genital endometriosis

DOI: https://doi.org/10.29296/25877305-2023-05-03
Issue: 
5
Year: 
2023

B. Baigalmaa(1, 2); Professor of the Russian Academy of Sciences V. Bitsadze(1), MD; Professor A. Solopova(1), MD; D. Blinov(1, 3, 4), Candidate of Medical Sciences; G. Bykovshchenko1
1-I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
2-Amgalan Maternal Hospital, Ulan-Bator, Mongolia
3-Institute of Preventive and Social Medicine, Moscow
4-F.P. Gaaz Moscow Medical and Social Institute,

External genital endometriosis (EGE) is a common disease that substantially lowers quality of life in women. EGE is accompanied by chronic pelvic pain in 50% of cases. The role of the hemostatic system, proinflammatory factors, the complement system, and other biomarkers in the pathogenesis of EGE seems interesting. The literature describes an endometriosis-characteristic (local and systemic) condition of local and systemic hypercoagulation, activation of proinflammatory molecules, chemokines, and complement components. It is remarkable that after surgical removal of endometrioid foci, the biochemical and coagulation parameters return to normal. The objective of this review is to summarize the data on the diagnostic and prognostic significance of hemostatic factors, proinflammatory cytokines, cancer markers, the immunological and genetic panels within the framework of EGE
Keywords: 
ynecology
endometriosis
hemostasis
hypercoagulation
proinflammatory cytokines
surgical procedure.

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