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Possibilities and prospects of epigenetic rehabilitation in patients with external genital endometriosis

DOI: https://doi.org/10.29296/25877305-2022-05-01
Issue: 
5
Year: 
2022

E. Begovich(1), Professor A. Solopova(1), MD; S. Khlopkova(2); A. Vlasina(1), V. Kuznetsova(1),
1-I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
2-L.A. Vorokhobov City Clinical Hospital Sixty-Seven, Moscow Healthcare Department

Epigenetics is a modern promising field that studies the activity of genes in response to environmental and lifestyle factors. Knowledge of epigenetic mechanisms, starting from intrauterine development, can expand the possibilities of timely treatment of external genital endometriosis, early prevention of relapses and carcinogenesis. The present review considers and systematizes data on the use of epigenetic mechanisms in rehabilitation based on the analysis of modern scientific medical literature, both domestic and foreign. This study showed that epigenetic mechanisms significantly affect the formation of external genital endometriosis and endometriosis-associated ovarian cancer. Standard therapy in combination with epigenetic rehabilitation will lead to a decrease in the recurrence of the disease and stabilization of the achieved results. Thus, it is crucially important to develop pathogenetically substantiated comprehensive rehabilitation schemes that will provide a personalized approach, timely prevention, prognosis and treatment of external genital endometriosis.

Keywords: 
gynecology
epigenetics
external genital endometriosis
lifestyle
environmental factors
rehabilitation



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