SCREENING FOR TUBERCULOSIS INFECTION IN MEDICAL STUDENTS
DOI: https://doi.org/10.29296/25877305-2022-03-06
Issue:
3
Year:
2022
Students of medical universities who study and work in medical institutions are at risk of
infection with Mycobacterium tuberculosis. The aim of the study was to study the results of in vivo
tuberculosis immunodiagnosis methods in medical university students. Materials and methods. The research
group consisted of medical university students aged 20–23 years who had a history of BCG vaccination in a
maternity hospital without revaccination. Two groups were formed. The first group of 330 people who were not
registered with a phthisiologist. The second group consisted of 68 people who were registered in the
tuberculosis dispensary in childhood and adolescence. They were given two tests at the same time. The
Mantoux test with 2TE in 0.1 ml PPD-L in standard dilution was placed on the right hand, and the Diaskintest
test at a dose of 0.2 mcg in 0.1 ml was placed on the left hand. Results. When analyzing the results of the
Mantoux test with 2 TU, the number of positive results was approximately the same, regardless of the
anamnesis data, and was recorded in the majority of the examined. A test with recombinant tuberculosis
allergen made it possible to identify «latent tuberculosis» in 2.2% of cases and form a high-risk group for
the development of the disease and take preventive measures.
Keywords:
mantoux test
Diaskintest
tuberculosis recombinant allergen
mycobacterium tuberculosis infection
students
tuberculosis
References:
- Sun' H., Din Sh., Huan H. Issledovanija sostojanija zdorov'ja studentov vysshih uchebnyh zavedenij. Perspektivy nauki. 2020; 7 (130): 153–5.
- Klimatskaja L.G., Zajtseva O.I., Kuz'min V.A. i dr. Meditsinskij aspekt zdorov'esohranjajuschego povedenija studentov vuzov Rossii i Vostochnoj Evropy. Zdorov'e cheloveka, teorija i metodika fizicheskoj kul'tury i sporta. 2019; 4 (15): 276–84.
- Borodulina E.A., Borodulin B.E., Amosova E.A. i dr. Tuberkulinovye proby i ih sravnitel'naja otsenka. Tuberkulez i bolezni legkih. 2010; 87 (8): 137.
- Borodulina E.A. Skrining tuberkuleznoj infektsii. sovremennye rekomendatsii. Allergologija i immunologija v pediatrii. 2017; 2 (49): 29–33.
- Borodulina E.A. Differentsial'naja diagnostika postvaktsinal'noj i infektsionnoj tuberkulinovoj allergii u detej s atopicheskimi zabolevanijami. Problemy tuberkuleza i boleznej legkih. 2006; 1: 9.
- Borodulina E.A., Amosova E.A., Borodulin B.E., i dr. Voprosy tuberkulinodiagnostiki u detej v sovremennyh uslovijah. Voprosy sovremennoj pediatrii. 2010; 9 (1): 70–4.
- Slogotskaja L.V., Bogorodskaja E.M., Senchihina O.Ju. i dr. Formirovanie grupp riska zabolevanija tuberkulezom pri razlichnyh immunologicheskih metodah obsledovanija detskogo naselenija. Rossijskij pediatricheskij zhurnal. 2017; 20 (4): 207–13. DOI: 10.18821/1560-9561-2017-20-4-207-213
- Starshinova A.A., Zinchenko Ju.S., Istomina E.V. i dr. Diagnostika latentnoj tuberkuleznoj infektsii v uchrezhdenijah razlichnogo profilja i formirovanie gruppy riska po zabolevaniju tuberkulezom. Biopreparaty. Profilaktika, diagnostika, lechenie. 2019; 19 (3): 178–84. DOI: 10.30895/2221-996X-2019-19-3-178-184
- Kudlaj D.A., Starshinova A.A., Dovgaljuk I.F. Allergen tuberkuleznyj rekombinantnyj: 10-letnij opyt primenenija testa u detej i podrostkov v rossijskoj federatsii (dannye metaanaliza). Pediatrija. Zhurnal im. G.N. Speranskogo. 2020; 99 (3): 121–9. DOI: 10.24110/0031-403X-2020-99-3-121-129
- Shilets Ju.G., Shilets O.G., Ivasivka A.R. i dr. Diagnosticheskaja znachimost' Diaskintesta u vzroslyh s podozreniem na tuberkulez. Avitsenna. 2018; 18: 57–60.
- Abinov O.A., Mal'tseva E.V., Fefilova G.A. Diagnosticheskie vozmozhnosti vnutrikozhnoj proby s allergenom tuberkuleznym rekombinantnym (Diaskintest®) dlja skrininga latentnogo i lokal'nogo tuberkuleza u vzroslogo naselenija. Nauchnyj meditsinskij vestnik Jugry. 2019; 2 (20): 75–7. DOI: 10.25017/2306-1367-2019-19-2-75-77
- Zaharov A.V., Vinogradova A.S., Gorenkova N.Ju. i dr. Skriningovye obsledovanija na tuberkulez v psihonevrologicheskih uchrezhdenijah s ispol'zovaniem Diaskintesta®. Tuberkulez i sotsial'no-znachimye zabolevanija. 2018; 3: 59–61.
- Slogotskaya L.V., Litvinov V., Kudlay D.A. et al. New skin test with recombinant protein CFP10-ESAT6 in patients (children and adults) with tuberculosis, non-tuberculosis disease and latent TB infection. Eur Resp J. 2012; 40 (S56): 416.
- Sun H., Ding Sh., Huang H. Health research into university students. Perspektivy nauki. 2020; 7 (130): 153–5 (in Russ.).
- Klimatckaia L.G., Zaitseva O.I., Kuzmin V.A. et al. Medical aspects of health-saving behavior of university students from Russia and Eastern Europe. Health, Physical Culture and Sports. 2019; 4 (15): 276–84 (in Russ.).
- Borodulina E.A., Borodulin B.E., Amosova E.A. et al. Tuberculin tests and their comparative assessment. Tuberculosis and Lung Diseases. 2010; 87 (8): 137 (in Russ.).
- Borodulina E.A. Screening for TB infection. Modern recommendations. Allergology and immunology in pediatrics. 2017; 2 (49): 29–33 (in Russ.).
- Borodulina E.A. Differentsial’naya diagnostika postvaktsinal’noi i infektsionnoi tuberkulinovoi allergii u detei s atopicheskimi zabolevaniyami. Problemy tuberkuleza i boleznei legkikh. 2006; 1: 9 (in Russ.).
- Borodulina E., Amosova E., Borodulin B. et al. Diagnostics with tuberculin in children in modern conditions. Current Pediatrics. 2010; 9 (1): 70–4 (in Russ.).
- Slogotskaya L.V., Bogorodskaya E.M., Senchikhina O.Yu. et al. Formation of risk groups for tuberculosis disease in various immunological methods of the examination of children population. Rossiyskiy Pediatricheskiy Zhurnal = Russian Pediatric Journal. 2017; 20 (4): 207–13 (in Russ.). DOI: 10.18821/1560-9561-2017-20-4-207-213
- Starshinova A.A., Zinchenko Yu.S., Istomina E.V. et al. Diagnosis of Latent Tuberculosis Infection in Personnel of Various Institutions and Determination of the Risk Group for Tuberculosis. BIOpreparations. Prevention, Diagnosis, Treatment. 2019; 19 (3): 178–84 (in Russ.) DOI: 10.30895/2221-996X-2019-19-3-178-184
- Kudlay D.A., Starshinova A.A., Dovgalyuk I.F. Recombinant tuberculosis allergen: 10 years of experience with the test in children and adolescents in the Russian Federation (meta analysis data). Pediatrics named after G.N. Speransky. 2020; 99 (3): 121–9 (in Russ.). DOI: 10.24110/0031-403X-2020-99-3-121-129
- Shilets Yu.G., Shilets O.G., Ivasivka A.R. et al. Diagnosticheskaya znachimost’ Diaskintesta u vzroslykh s podozreniem na tuberkulez. Avitsenna. 2018; 18: 57–60 (in Russ.).
- Abinov O.A., Mal’tseva E.V., Fefilova G.A. Diagnostic possibilities of intra-spring images with allergen tuberculosis recombinant (Diaskintest®) for latent and local tuberculosis screening in adult population. Nauchnyi meditsinskii vestnik Yugry. 2019; 2 (20): 75–7 (in Russ.). DOI: 10.25017/2306-1367-2019-19-2-75-77
- Zakharov A.V., Vinogradova A.S., Gorenkova N.Yu. et al. Skriningovye obsledovaniya na tuberkulez v psikhonevrologicheskikh uchrezhdeniyakh s ispol’zovaniem Diaskintesta®. Tuberkulez i sotsial’no-znachimye zabolevaniya. 2018; 3: 59–61 (in Russ.).
- Slogotskaya L.V., Litvinov V., Kudlay D.A. et al. New skin test with recombinant protein CFP10-ESAT6 in patients (children and adults) with tuberculosis, non-tuberculosis disease and latent TB infection. Eur Resp J. 2012; 40 (S56): 416.