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Hyperuricemia: pathophysiological aspects, significance in clinical practice

DOI: https://doi.org/10.29296/25877305-2022-02-12

Professor N. Kunitskaya, MD; Professor A. Aryev, MD; Associate Professor V. Polyakova,
Candidate of Medical Sciences; Professor V. Dobritsa, MD I.I. Mechnikov North-West State Medical University
Russian Ministry of Health, Saint Petersburg

Hyperuricemia, an increase in serum uric acid (UA) concentration above 420 μmol/L for men and 360 μmol/L for women (clinical guidelines of the Russian Association of Rheumatologists (2018)), is a common problem in clinical practice. Existing clinical guidelines regulate the management of patients with symptomatic hyperuricemia, primarily gout, urolithiasis, and acute urate nephropathy, but less attention is given to the primary prevention of these diseases and to the treatment of asymptomatic hyperuricemia. It is also known that UA and, consequently, hyperuricemia are also important in the development of cardiovascular diseases, primarily hypertension, heart failure and chronic kidney disease, and meanwhile, the treatment of asymptomatic hyperuricemia in these patients still depends on the doctor’s opinion. This review analyzed current trends in the treatment of patients with symptomatic and asymptomatic hyperuricemia according to current views on the role of UA in the development of gout, renal, cardiovascular, and other diseases.

concomitant pathology
uric acid
urate-reducing therapy

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