Phenotypes of occupational bronchial asthma (functional, immunological features, prognosis)
DOI: https://doi.org/10.29296/25877305-2022-02-08
Issue:
2
Year:
2022
Occupational asthma is a complex and heterogeneous disease. Development of personalized treatment
and prevention tactics becomes feasible due to phenotyping, which means identifying of markers to combine
cases of occupational asthma with similar manifestations (clinical, instrumental, laboratory) and prognosis
to phenotypes. The study aims to determination and comparative analysis of spirographic and immunological
parameters for different phenotypes of occupational asthma. Materials and methods. In this study, we
included 170 patients with different phenotypes of occupational asthma and 50 participants in control group.
The spirographic examination was performed using computer spirograph with determination of the following
parameters: forced vital capacity (FVC), forced expiratory volume during the first second (FEV1),
Tiffeneau-Pinelli index (FEV1/FVC), peak expiratory flow (PEF), maximal expiratory flow at 75%, 50%, 25% of
the forced vital capacity (MEF75%VC, MEF50%VC, MEF25%VC). Quantification of the immunoglobulins IgA, IgM,
and IgG in human serum was conducted by Mancini method. Determination of cytokines IL-1β, IL-10, IFNγ, IgE
total and fibronectin levels was hold using a solid-phase enzyme immunoassay. Results. According to
spirometry and laboratory results obtained, there is a strong evidence, that the phenotype “occupational
asthma – occupational chronic obstructive pulmonary disease” has the lowest values in pulmonary function
tests and the most significant changes in immunoglobulins, cytokines and fibronectin levels among other
studied phenotypes of occupational asthma. Conclusions. Dynamic determination of spirometry parameters,
levels of immunoglobulins, cytokines IL-1β, IL-10, IFNγ and fibronectin in workers who are most at risk of
developing occupational asthma may be recommended to be conducted once every six months with further
phenotyping of identified cases. This can optimize the diagnosis, the choice of treatment and prevention
tactics as well as predict the course of this pathology.
Keywords:
pulmonology
occupational asthma
phenotype
spirometry
immunoglobulins
fibronectins
cytokines
References:
- Professional'naja bronhial'naja astma. Federal'nye klinicheskie rekomendatsii. Utverzhdeny Assotsiatsiej vrachej i spetsialistov meditsiny truda. M., 2017 [Professional bronchial asthma. Federal clinical guidelines. Approved by the Association of doctors and specialists in occupational medicine. M., 2017 (in Russ.)].
- GINA Report, Global Strategy for Asthma Management and Prevention. Published November 2018. Available at: http://www.ginasthma.org
- Nenasheva N.M. Fenotipy bronhial'noj astmy i vybor terapii. Prakticheskaja pul'monologija. 2014; 2: 2–11 [Nenasheva NM. Phenotypes of bronchial asthma and the choice of therapy. Prakticheskaya pul’monologiya. 2014; 2: 2–11 (in Russ.)].
- Kurbacheva O.M. Bronhial'naja astma. Chto mozhno sdelat' dlja dostizhenija kontrolja zabolevanija? Rossijskij allergologicheskij zhurnal. 2012; 2: 28–34 [Kurbacheva OM. Bronchial asthma. What can be done to achieve disease control? Rossiiskii allergologicheskii zhurnal. 2012; 2: 28–34 (in Russ.)].
- Tilles S.A., Jerath-Tatum A. Differential diagnosis of occupational asthma. Immunol Allergy Clin N Am. 2003; 23 (2): 167–76. DOI: 10.1016/s0889-8561(02)00089-9
- Nikolskii A.A., Shilovskiy I.P., Andreev S.M. et al. STAT3 gene suppression as an approach for the treatment of non-allergic bronchial asthma. Allergy. 2019; 74 (s106): 67.
- Sastre J., Vandesplas O., Park H.S. Pathogenesis of occupational asthma. Eur Respir J. 2003; 22 (2): 364–7. DOI: 10.1183/09031936.03.00045103
- Wan H., Winton H.L., Soeller C. et al. Der p1 facilitates transepithelial allergen delivery by disruption of tight functions. J Clin Invest. 1999; 104 (1): 123–33. DOI: 10.1172/JCI5844
- Agius R.M., Nee J., Mc Govern B. et al. Structure activity hypotheses in occupational asthma caused by low molecular weight substances. Ann Occup Hyg. 1991; 35 (2): 129–31. DOI: 10.1093/annhyg/35.2.129
- Niespodziana K., Borochova K., Pazderova P. et al. Toward personalization of asthma treatment according to trigger factors. J Allergy Clin Immunol. 2020; 145 (6): 1529–34. DOI: 10.1016/j.jaci.2020.02.001
- Cormier M., Lemière C. Occupational asthma. Int J Tuberc. Lung Dis. 2020; 24 (1): 8–21. DOI: 10.5588/ijtld.19.0301
- Vandenplas O., Suojalehto H., Cullinan, P. Diagnosing occupational asthma. Clin Exp Allergy. 2017; 47 (1): 6–18. DOI: 10.1111/cea.12858