Local recurrences of breast cancer after organ-sparing treatment: the site of oncoplastic resections and risk factors

DOI: https://doi.org/10.29296/25877305-2021-08-01
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Issue: 
8
Year: 
2021

A. Zikiryakhodzhaev(1)–3, MD; E. Rasskazova(1), Candidate of Medical Sciences; D. Omarova(2);
F. Khugaeva(2); D. Ortabaeva(1); A. Tregubova(1); Professor I. Reshetov(2), Academician of the Russian
Academy of Sciences, MD; Professor A. Kaprin(3, 4), Academician of the Russian Academy of Sciences, MD
(1)P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center,
Ministry of Health of Russia (2)I.M. Sechenov First Moscow State Medical University (Sechenov University),
Ministry of Health of Russia (3)Peoples’ Friendship University of Russia, Moscow (4)National Medical
Radiology Research Center, Ministry of Health of Russia, Obninsk

Breast cancer (BC) holds the lead in the structure of cancer incidence in women. A comprehensive approach to treating BC patients, which includes highly effective drug treatment options and postoperative radiation therapy, allows surgeons to perform operations of various volumes: from tumorectomies to radical mastectomies with breast reconstruction. Organ-sparing operations (OSO) in the combined/combination treatment of BC lead to equal relapse-free and overall survival rates compared to mastectomies, despite the higher frequency of local relapses. The widespread use of oncoplastic resections over the past decades, which combine the principles of oncological safety and aesthetic surgery, has made it possible to expand indications for organ-sparing treatment in BC. Today, the issues of oncological safety of OSO involving both conventional (tumorectomy, lumpectomy, quadranectomy) and oncoplastic resections do not lose their relevance. In addition, owing to a personalized approach to treating BC, the question of determining the predictors of local relapse after OSO remains interesting. This paper provides a literature review reflecting the oncological results of OSO in BC patients, as well as the factors influencing the frequency of local recurrences.
Keywords: 
oncology
breast cancer
organ-sparing treatment
oncoplastic resections
local recurrences
hormone therapy
breast resection

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