Optimization of treatment for postoperative peritonitis in patients with Stage IV cancer

DOI: https://doi.org/10.29296/25877305-2021-05-08
Download full text PDF
Issue: 
5
Year: 
2021

A.K. Antonov(1), Candidate of Medical Sciences; D. Vychuzhanin(2), Candidate of Medical
Sciences; A. Filimonyuk-Smelkov(3), MD; E. Solod(4), MD; K. Antonov(4); A.A. Antonov(4); R. Gorenkov(1, 2),
MD; Professor A. Simonova(1), MD; P. Ovchinnikova(2) (1)M.F. Vladimirsky Moscow Regional Research Clinical
Institute, Moscow (2)I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of
Health of Russia (3)Hospital of the Research Center, Russian Academy of Sciences, Chernogolovka (4)N.N.
Priorov National Medical Research Center for Traumatology and Orthopedics, Moscow

Treatment for postoperative peritonitis in patients with Stage IV cancer is an urgent and considerable problem. In the cancer patients, the mortality rate from postoperative peritonitis without treatment reaches almost 100%; that after treatment is 60-90%. Despite the currently used powerful modern antibiotics and antiseptics, the results of treatment for postoperative peritonitis, especially in advanced cancer patients, remain disappointing. Continuous search is underway toward effective methods of accompanying therapy, along with basic one, to improve the treatment of postoperative peritonitis in cancer patients and to accelerate recovery in the early postoperative period (fast-track surgery). The authors have developed a unique accompanying therapy for the surgical treatment of postoperative peritonitis in patients with Stage IV cancer, by using an adaptogenic immunomodulator (Altai extract) along with the neutral anolyte – a metastable mixture of peroxides formed during electrochemical reactions.
Keywords: 
surgery
oncology
therapy
postoperative peritonitis in patients with Stage IV cancer
Altai extract
neutral anolyte – a metastable mixture of peroxides formed during electrochemical reactions

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Hachatrjan N.N. Formirovanie zaschitno-adaptivnyh mehanizmov i ih korrektsija pri peritonite. Avtoref. dis. ... d-ra med. nauk. M., 1995; 50 s. [Khachatryan N.N. Formirovanie zashchitno-adaptivnykh mekhanizmov i ikh korrektsiya pri peritonite. Avtoref. dis. ... d-ra med. nauk. M., 1995; 50 s. (in Russ.)].
  2. Lebedev N.V., Klimov A.E., Barhudarov A.A. Peritonit. Ucheb. posob. M.: BINOM, 2017; 56 s. [Lebedev N.V., Klimov A.E., Barkhudarov A.A. Peritonit. Ucheb. posob. M.: BINOM, 2017; 56 s. (in Russ.)].
  3. Savel'ev V.S. Peritonit. Prakticheskoe rukovodstvo. Pod red. V.S. Savel'eva, B.R. Gel'fanda, M.I. Filimonova. M.: Litterra, 2006; 208 s. [Savel’ev V.S. Peritonit. Prakticheskoe rukovodstvo. Pod red. V.S. Savel’eva, B.R. Gel’fanda, M.I. Filimonova. M.: Litterra, 2006; 208 s. (in Russ.)].
  4. Zaporozhets A.A. Posleoperatsionnyj peritonit: patogenez i profilaktika. Minsk: Nauka i tehnika, 1974; 182 s. [Zaporozhets A.A. Posleoperatsionnyi peritonit: patogenez i profilaktika. Minsk: Nauka i tekhnika, 1974; 182 s. (in Russ.)].
  5. Erohin I.A., Shljapnikov S.A. Tjazhelaja abdominal'naja infektsija, problema peritonita i abdominal'nyj sepsis. Hirurgija. Zhurn. im. N.I. Pirogova. 2006; 2: 9–14 [Erokhin I.A., Shlyapnikov S.A. Tyazhelaya abdominal’naya infektsiya, problema peritonita i abdominal’nyi sepsis. Khirurgiya. Zhurn. im. N.I. Pirogova. 2006; 2: 9–14 (in Russ.)].
  6. Shurkalin B.K., Faller A.P., Gorskij V.A. i dr. Posleoperatsionnye oslozhnenija u bol'nyh s peritonitom. Hirurgija. Zhurn. im. N.I. Pirogova. 2003; 4: 32–5 [Shurkalin B.K., Faller A.P., Gorskii V.A. et al. Posleoperatsionnye oslozhneniya u bol’nykh s peritonitom. Khirurgiya. Zhurn. im. N.I. Pirogova. 2003; 4: 32–5 (in Russ.)].
  7. Laberko L.A., Kuznetsov N.A., Rodoman G.V. i dr. Individual'nyj prognoz tjazhesti techenija posleoperatsionnogo perioda i ishoda rasprostranennogo peritonita. Hirurgija. Zhurn. im. N.I. Pirogova. 2005; 2: 29–33 [Laberko L.A., Kuznetsov N.A., Rodoman G.V. et al. Individual’nyi prognoz tyazhesti techeniya posleoperatsionnogo perioda i iskhoda rasprostranennogo peritonita. Khirurgiya. Zhurn. im. N.I. Pirogova. 2005; 2: 29–33 (in Russ)].
  8. Seymour C.W., Liu V.X., Iwashyna N.J. et al. Assessment of Clinical Criteria for Sepsis For the Third International Consensus Definitions for Sepsis and Septic Shock (Sesis-3). JAMA. 2016; 315 (8): 762–74. DOI: 10.1001/jama.2016.0288
  9. Pisano M., Zorcolo L., Merli C. et al. 2017 WSES guidelines on colon and rectal cancer emergencies: obstruction and perforation. World J Emerg Surg. 2018; 13: 36. DOI: 10.1186/s13017-018-0192-3
  10. Sartelli M., Abu-Zidan F.M., Catena F. et al. Global validation of the WSES Sepsis Severity Score for patients with complicated intraabdominal infections: a prospective multicenter study (WISS Study). World J Emerg Surg. 2015; 10: 61. DOI: 10.1186/s13017-015-0055-0
  11. Tolonen M., Sallinen V., Leppäniemi A. et al. The role of the intra-abdominal view in complicated intraabdominal infections. World J Emerg Surg. 2019; 14: 15. DOI: 10.1186/s13017-019-0232-7
  12. Bagnenko S.F., Belotserkovskij B.Z., Briskin B.S. i dr. Peritonit. Prakt. ruk. Pod red. V.S. Savel'eva, B.R. Gel'fanda, Ros. Assots. Spetsialistov po hirurg. infektsijam. M.: Litterra, 2006; 205 c. [Bagnenko S.F., Belotserkovskii B.Z., Briskin B.S. i dr. Peritonit. Prakt. ruk. Pod red. V.S. Savel’eva, B.R. Gel’fanda, Ros. Assots. Spetsialistov po khirurg. infektsiyam. M.: Litterra, 2006; 205 s. (in Russ.)].
  13. Lechenie peritonita metodom laparostomii s primeneniem vakuumnogo drenirovanija brjushnoj polosti. Metodicheskoe rukovodstvo. Pod red. S.G. Scherbaka. SPb: Korona.Vek, M.: BINOM, 2019; 72 c. [Lechenie peritonita metodom laparostomii s primeneniem vakuumnogo drenirovaniya bryushnoi polosti. Metodicheskoe rukovodstvo. Pod red. S.G. Shcherbaka. SPb: Korona.Vek, M.: BINOM, 2019; 72 s. (in Russ.)].
  14. Kostjuchenko K.V., Rybachkov V.V. Printsipy opredelenija hirurgicheskoj taktiki lechenija rasprostranennogo peritonita. Hirurgija. Zhurn. im. N.I. Pirogova. 2005; 4: 9–13 [Kostyuchenko K.V., Rybachkov V.V. Printsipy opredeleniya khirurgicheskoi taktiki lecheniya rasprostranennogo peritonita. Khirurgiya. Zhurn. im. N.I. Pirogova. 2005; 4: 9–13 (in Russ.)].
  15. Filimonov M.I., Podachin P.V. Ranevye oslozhnenija pri etapnom hirurgicheskom lechenii peritonita (soobschenie 1). Annaly hirurgii. 2005; 3: 32–6 [Filimonov M.I., Podachin P.V. Ranevye oslozhneniya pri etapnom khirurgicheskom lechenii peritonita (soobshchenie 1). Annaly khirurgii. 2005; 3: 32–6 (in Russ.)].
  16. Coccolini F., Roberts D.J., Ansaloni L. et al. The open abdomen in trauma and nontrauma patients: WSES guidelines. World J Emerg Surg. 2018; 13: 7. DOI: 10.1186/s13017-018-0167-4
  17. Coccolini F., Biffl W., Catena F. et al. The open abdomen, indications, management and definitive closure. World J Emerg Surg. 2015; 10: 32. DOI: 10.1186/s13017-015-0026-5
  18. Kirkpattick A.W. Closed Or Open after Source Control Laparotomy for Severe Complicated IntraAbdominal Sepsis (the COOL trial): study protocol for a randomized controlled trial. World J Emerg Surg. 2018; 13: 26. DOI: 10.1186/s13017-018-0183-4
  19. Vlasov A.P., Bolotskih V.A., Vlasova T.I. i dr. Povyshenie detoksikatsionnoj sposobnosti organizma pri hirurgicheskom endotoksikoze. Hirurgija. Zhurn. im. N.I. Pirogova. 2019; 6: 73–9. [Vlasov A.P., Bolotskikh V.A., Vlasova T.I. et al. Intensification of the organism detoxification ability under surgical endogenous intoxication. Khirurgiya. Zhurn. im. N.I. Pirogova. 2019; 6: 73–9 (in Russ.)]. DOI: 10.17116/hirurgia201906173
  20. Leonov B.I., Bahir V.M., Vtorenko V.I. Elektrohimicheskaja aktivatsija v prakticheskoj meditsine. Vtoroj Mezhdunarodnyj simpozium «Elektrohimicheskaja aktivatsija». Tez. dokl. i kratkie soobschenija, ch.1. M., 1999; s. 15–23 [Leonov B.I., Bakhir V.M., Vtorenko V.I. Elektrokhimicheskaya aktivatsiya v prakticheskoi meditsine. Vtoroi Mezhdunarodnyi simpozium «Elektrokhimicheskaya aktivatsiya». Tez. dokl. i kratkie soobshcheniya, ch.1. M., 1999; s. 15–23 (in Russ.)].