Specific features of the etiology and pathogenesis of cleft lip and palate of the maxillofacial area

DOI: https://doi.org/10.29296/25877305-2021-02-03
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Issue: 
2
Year: 
2021

O. Dudnik, Candidate of Medical Sciences; Professor A. Mamedov, MD; D. Bille; A. Chertikhina;
A. Beznosik I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of
Russia

Cleft lip and palate (CLP) is one of the most prevalent pathologies of the maxillofacial region. Nowadays, knowledge about the various etiopathogenetic factors of this pathology and their prevalence plays an important role, which will help not only in early diagnosis and counseling of expectant parents, but also in planning an interdisciplinary approach to diagnosis and treatment. The aim of the study was to identify etiological risk factors and the mechanism of CLP development, as well as to analyze the frequency of this pathology. The information analysis of 40 sources of domestic and foreign literature for the period from 2003 to 2019 was carried out. A close relationship between etiological risk factors and the birth rate of children with CLP was revealed.
Keywords: 
cleft lip
cleft palate
etiology
pathogenesis
prevalence

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