ANALYSIS OF THE RESULTS OF FIVE-YEAR COMBINATION TREATMENT IN CHRONIC HEPATITIS C PATIENTS WITH SEVERE LIVER FIBROSIS AND CYTOPENIA

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Issue: 
11
Year: 
2017

S. Vasilyev; Professor L. Popova, MD; D. Konstantinov, Candidate of Medical Sciences Samara State Medical University

The Infectious Diseases Clinic, Samara State University, has followed up chronic hepatitis C patients with end-stage liver fibrosis and cytopenia for 5 years. Their treatment with no possibilities of etiotropic therapy along with conventional pathogenetic therapy used the Russian recombinant interleukin-2 (IL-2) (rIL-2) Roncoleukin®. By having a comprehensive, including substitutive immunorestorative, effect, the authors’ proposed scheme for the management of patients, allows one to long preserve the compensatory abilities of the liver and immune system, giving the opportunity to return to the discussion of etiotropic treatment after a certain period when the patient’s condition is improved (and/or the terms of financing are changed).
Keywords: 
chronic hepatitis C
immunopathogenetic therapy
cellular immunity
cytopenia

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References: 
  1. Nikitin I.G. Ekonomicheskoe bremja hronicheskogo gepatita S v Rossii // Epidemiol. i infekts. bolezni. – 2015; 6: 1–5.
  2. Vasil'ev S.Ju. Tsitopenicheskij sindrom u bol'nyh HCV-infektsiej s vyrazhennym fibrozom // Aspirantskij vestnik Povolzh'ja. – 2014; 1–2: 23–6.
  3. Egorova V.N., Popovich A.M., Babachenko I.V. i dr. Interlejkin-2: obobschennyj opyt klinicheskogo primenenija / SPb: Ul'tra Print, 2012; 98 s.
  4. Popova L.L. Kliniko-patogeneticheskoe obosnovanie strategii i taktiki immunoterapii pri hronicheskom virusnom gepatite S. Avtoref. dis. … d-ra med. nauk. Samara, 2009.
  5. Popova L.L. Osobennosti immunnogo otveta bol'nyh virusnym gepatitom S na fone provedenija protivovirusnoj terapii. Monografija / Samara: Izdatel'stvo As Gorod, 2012.
  6. Popova L.L., Suzdal'tsev A.A., Konstantinov D.Ju. i dr. Opyt primenenija kombinatsii al'faferona i ronkolejkina v kompleksnom lechenii hronicheskogo gepatita S // Eksperim. i klin. gastroenterol. – 2011; 6: 102–7.
  7. Konstantinov D.Ju., Konstantinova E.A., Nedugov G.V. i dr. Vozmozhnosti neinvazivnogo opredelenija stadii fibroza pecheni u patsientov s hronicheskim virusnym gepatitom S // Sib. med. zhurn. (Irkutsk). – 2013; 123 (8): 71–4.
  8. Vasil'ev S.Ju. Harakteristika stadii fibroza pecheni u bol'nyh s NSV-infektsiej po rezul'tatam instrumental'nogo i gistologicheskogo obsledovanija // Aspirantskij vestnik Povolzh'ja. – 2013; 1–2: 31–6.
  9. Suzdal'tsev A.A., Popova L.L., Konstantinov D.Ju. i dr. Sposob neinvazivnogo opredelenija stadii fibroza pecheni u patsientov s hronicheskim virusnym gepatitom. Patent RF №2425633C2, 2011.