EPSTEIN-BARR VIRUS INFECTION: PATHOGENESIS AND ASSOCIATION WITH PRIMARY IMMUNODEFICIENCY: ANALYSIS OF CLINICAL CASES

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Issue: 
12
Year: 
2016

G. Vikulov, Candidate of Medical Sciences D.I. Ivanovsky Institute of Virology, N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology, Moscow Research Center for Prevention and Treatment of Viral Infections, Moscow Biocode Med Clinic, Moscow

Herpesvirus infections are very frequently encountered by physicians in their practice. The Epstein-Barr virus occupies a particular position among human herpes viruses not only due to that it is a common cause of infectious mononucleosis, but also it is associated with oncogene-mediated cellular transformation, development of overfatigability and chronic fatigue syndrome, with immune dysfunction and exposure to man-made and medically indicated ionizing radiation in the history.
Keywords: 
Epstein-Barr virus
immunodeficiencies
lymphoproliferative syndrome

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References: 
  1. Oradovskaja I.V. Immunologicheskij monitoring bol'shih grupp naselenija, vkljuchaja kontingent lits, uchastvovavshih v likvidatsii posledstvij avarii na Chernobyl'skoj AES. Avtoref. dis. … d-ra med. nauk. M., 1991.
  2. Belozerov E.S., Bulan'kov Ju.I. Mitin Ju.A. Bolezni immunnoj sistemy / Elista, 2005.
  3. Vikulov G.H. Gerpesvirusnye infektsii cheloveka v novom tysjacheletii: klassifikatsija, epidemiologija i mediko-sotsial'noe znachenie. Epidemiologija i infektsionnye bolezni // Aktual'nye voprosy. – 2014; 3: 35–40.
  4. L'vov N.D. Gerpesvirusnye infektsii. Rukovodstvo po virusologii pod red. akad. D.K. L'vova / M., 2013.
  5. Isakov V.A. Gerpesvirusnye infektsii. Rukovodstvo dlja vrachej / SPb, 2013.
  6. Artsimovich N.G., Galushina T.S. Sindrom hronicheskoj ustalosti / M.: Nauchnyj mir, 2002.
  7. Purtilo D., Liao S., Sakamoto K. et al. Diverse familial malignant tumors and Epstein–Barr virus // Cancer Res. – 1981; 11 (Pt. 1): 4248–52.
  8. Kondratenko I.V., Bologov A.A. i dr. Pervichnye immunodefitsity / M.: Medpraktika-M, 2005.
  9. Haitov R.M., Jarilin A.A., Pinegin B.V. Immunologija: atlas / M.: GEOTAR-Media; s. 492–5.
  10. Zakljaz'minskaja E.V., Kondratenko I.V., Bologov A.A. i dr. Etiologija i DNK-diagnostika X-stseplennogo limfoproliferativnogo sindroma (bolezni Dunkan) // Meditsinskaja genetika. – 2005; 4 (11): 512–5.
  11. Romanishin Ja.Ju., Kostjuchenko L.V., Vygovskaja L.S. H-stseplennyj limfoproliferativnyj sindrom // Sovremennaja pediatrija. – 2011; 2 (36): 79.
  12. Lerner A., Beqaj S., Deeter R. et al. A six-month trial of valacyclovir in the Epstein-Barr virus subset of chronic fatigue syndrome: improvement in left ventricular function // Drugs Today (Barc). – 2202; 38 (8): 549–61.