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AN ALGORITHM FOR SWITCHING FROM STIMULANT LAXATIVES TO OSMOTIC AGENTS

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Issue: 
12
Year: 
2016

T. Oganesyan, Candidate of Medical Sciences; Yu. Kucheryavyi, Candidate of Medical Sciences; S. Cheremushkin, Candidate of Medical Sciences; A. Goncharenko, Candidate of Medical Sciences; E. Barkalova; Professor I. Maev, Corresponding Member of the Academy of Russian Sciences A.I. Evdokimov Moscow State University of Medicine and Dentistry

The authors elaborated the management tactics for patients with chronic constipation, which included the use of polyethylene glycol (macrogol, Forlax) and the gradual reduction in the stimulant laxative until it was completely discontinued. The therapy was effective in 91.2% of the patients.

Keywords: 
gastroenterology
сhronic constipation
refractoriness
safety
laxatives
algorithm
macrogol



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References: 
  1. Enck P., Leinert J., Smid M. et al. Prevalence of constipation in the German population – a representative survey (GECCO) // United Eur. Gastroenterol. J. – 2016; 4 (3): 429–37.
  2. Kazjulin A.N., Kucherjavyj Ju.A. Prakticheskie i klinicheskie aspekty sindroma hronicheskogo zapora. Metodicheskoe rukovodstvo dlja vrachej / M.: VUNMTs, 2005; 38 s.
  3. Pare P., Ferrazzi S., Thompson W. et al. An epidemiological survey of constipation in Canada: definitions, rates, demographics, and predictors of health care seeking // Am. J. Gastroenterol. – 2001; 96 (11): 3130–7.
  4. Mugie S., Di Lorenzo C., Benninga M. Constipation in childhood // Nat. Rev. Gastroenterol. Hepatol. – 2011; 8 (9): 502–11.
  5. Cheremushkin S.V., Kucherjavyj Ju.A. Dokazatel'naja meditsina i lechenie hronicheskogo zapora // Vrach. – 2012; 10: 42–7.
  6. Flourié B., Not D., François C. et al. Factors associated with impaired quality of life in French patients with chronic idiopathic constipation: a cross-sectional study // Eur. J. Gastroenterol. Hepatol. – 2016; 28 (5): 525–31.
  7. Maevskaja E.A., Kucherjavyj Ju.A., Maev I.V. Nealkogol'naja zhirovaja bolezn' pecheni i hronicheskij zapor: sluchajnaja ili ochevidnaja assotsiatsija v praktike gastroenterologa? // Klin. perspektivy gastroenterol., gepatol. – 2015; 1: 27–36.
  8. Choung R., Rey E., Richard Locke G. 3rd. et al. Chronic constipation and co-morbidities: A prospective population-based nested case-control study // United Eur. Gastroenterol. J. – 2016; 4 (1): 142–51.
  9. Guérin A. et al. Risk of developing colorectal cancer and benign colorectal neoplasm in patients with chronic constipation // Aliment. Pharmacol. Ther. – 2014; 40 (1): 83–92.
  10. Shin J., Jung H., Lee T. et al. Guidelines for the Diagnosis and Treatment of Chronic Functional Constipation in Korea, 2015 Revised Edition // J. Neurogastroenterol. Motil. – 2016; 22 (3): 383–411.
  11. Serra J., Mascort-Roca J., Marzo-Castillejo M. et al. Clinical practice guidelines for the management of constipation in adults. Part 2: Diagnosis and treatment // Gastroenterol. Hepatol. – 2016: S0210-5705(16)30004-8.
  12. Ivashkin V.T., Abdulhakov S.R., Baranskaja E.K. i dr. Klinicheskie rekomendatsii Rossijskoj gastroenterologicheskoj assotsiatsii po diagnostike i lecheniju vzroslyh patsientov s hronicheskim zaporom // RGGZhK. – 2014; 5: 69–75.
  13. Maev I.V., Maevskaja E.A., Cheremushkin S.V. i dr. Realii i perspektivy lechenija hronicheskogo zapora // Klin. perspektivy gastroenterol., gepatol. – 2014; 6: 30–6.
  14. Maev I., Andreev D., Dicheva D. i dr. Risk dlitel'nogo primenenija slabitel'nyh preparatov // Vrach. – 2014; 1: 26–30.
  15. Cheremushkin S.V., Kucherjavyj Ju.A., Goncharenko A.Ju. i dr. Retrospektivnaja otsenka effekta posledejstvija polietilenglikolja pri lechenii hronicheskogo zapora // Vrach. – 2013; 3: 58–62.
  16. Johanson J., Kralstein J. Chronic constipation: a survey of the patient perspective // Aliment. Pharmacol. Ther. – 2007; 25: 599–608.
  17. Suares N., Ford A. Systematic review: the effects of fiber in the management of chronic idiopathic constipation // Aliment. Pharmacol. Ther. – 2011; 33: 895–901.
  18. Muller-Lissner S., Kamm M., Scarpignato C. et al. Myths and misconceptions about chronic constipation // Am. J. Gastroenterol. – 2005; 100: 232–42.
  19. Dukas L., Willett W., Giovannucci E. Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women // Am. J. Gastroenterol. – 2003; 98: 1790–6.
  20. Liu L. Chronic constipation: current treatment options // Can. J. Gastroenterol. – 2011; 25 (Suppl. B): 22–8.
  21. Corazziari E., Badiali D., Bazzocchi G. et al. Longterm efficacy, safety, and tolerabilitity of low daily doses of isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in the treatment of functional chronic constipation // Gut. – 2000; 46: 522–6.
  22. DiPalma J., DeRidder P., Orlando R. et al. A randomized, placebo-controlled, multicenter study of the safety and efficacy of a new polyethylene glycollaxative // Am. J. Gastroenterol. – 2000; 95: 446–50.
  23. Cinca R., Chera D., Gruss H. et al. Randomised clinical trial: macrogol/PEG 3350+electrolytes versus prucalopride in the treatment of chronic constipation – a comparison in a controlled environment // Aliment. Pharmacol. Ther. – 2013; 37 (9): 876–86.
  24. Corazziari E., Badiali D., Bazzocchi G. et al. Long term efficacy, safety, and tolerabilitity of low daily doses of isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in the treatment of functional chronic constipation // Gut. – 2000; 46: 522–6.
  25. Treepongkaruna S., Simakachorn N., Pienvichit P. et al. A randomised, double-blind study of polyethylene glycol 4000 and lactulose in the treatment of constipation in children // BMC Pediatr. – 2014; 14 (1): 153.