EFFECTIVENESS OF PLASMOTHERAPY IN VARIOUS NOSOLOGIES

DOI: https://doi.org/10.29296/25877305-2023-07-07
Issue: 
7
Year: 
2023

A. Morozov, Candidate of Medical Sciences; V. Dadabaev, MD; V. Kurkova;
S. Semenova; L. Potockaya; M. Belyak
Tver State Medical University, Ministry of Health of Russia

The article provides a review of research on the effectiveness of plasma therapy the main and/or additional method of treatment of various diseases. PRP therapy is a treatment method based on the administration of autologous plasma to the patient containing a high concentration of platelets and growth factors that contribute to neocollagenesis, angiogenesis, general stem cell proliferation and soft tissue remodeling. Since autologous biological material is used, the possibility of developing an infectious or allergic process is excluded. The method is characterized by low toxicity, and also has an immunomodulatory, anti-inflammatory and regenerative effect. The positive aspects of the application of this method in most studies in most sources are noted. It is known that PRP preparations have a high regenerative potential, since they have the best physiological proportions of growth factors, which contributes to its recommendation for widespread use in clinical practice.

Keywords: 
plasma therapy
PRP-therapy
autologous plasma
platelet rich plasma.



References: 
  1. Emer J. Platelet-Rich Plasma (PRP): Current Applications in Dermatology. Skin Therapy Letter. 2019; 24 (5): 1–6.
  2. Бурганова К. И., Гареева Д.В., Галиева Э.И. Применение метода Плазмолифтинг в стоматологии. Мат-лы XXIV Междунар. юбилейн. симпоз. «Инновационные технологии в стоматологии», посвящ. 60-летию стоматологического факультета Омского государственного медицинского университета. Сб. ст. Омск, 24–25 ноября 2017 г. Ред. Г.И. Скрипкина. Омск: ООО «Издательский центр КАН», 2017; 74–7 [Burganova K. I., Gareeva D.V., Galieva E.I. Primenenie metoda Plazmolifting v stomatologii. Mat-ly XXIV Mezhdunar. yubilein. simpoz. «Innovatsionnye tekhnologii v stomatologii», posvyashch. 60-letiyu stomatologicheskogo fakul'teta Omskogo gosudarstvennogo meditsinskogo universiteta. Sb. st. Omsk, 24–25 noyabrya 2017 g. Red. G.I. Skripkina. Omsk: OOO «Izdatel'skii tsentr KAN», 2017; 74–7 (in Russ.)].
  3. Кошелева И.В., Шадыжева Л.И., Переверзина Н.О. и др. Плазмотерапия: методики и области применения. Лечащий врач. 2018; 1: 59 [Kosheleva I.V., Shadyzheva L.I., Pereverzina N.O. et al. Plasmatherapy: methods and fields of application. Lechaschi Vrach. 2018; 1: 59 (in Russ.)].
  4. Темкин Э.С., Дорожкина Л.Г., Кремнева Д.С. Эффективность использования Plasmolifting при имплантации у пациентов с воспалительными заболеваниями пародонта. Вестник Волгоградского государственного медицинского университета. 2018; 15 (1): 63–6 [Temkin E.S., Dorozhkina L.G., Kremneva D.S. Efficiency of use of Plasmolifting in implantation in patients with inflammatory diseases of a parodont. Journal of Volgograd State Medical University. 2018; 15 (1): 63–6 (in Russ.)]. DOI: 10.19163/1994-9480-2018-1(65)-63-66.
  5. Bos-Mikich A., de Oliveira R., Frantz N. Platelet-rich plasma therapy and reproductive medicine. J Assist Reprod Genet. 2018; 35 (5): 753–6. DOI: 10.1007/s10815-018-1159-8
  6. Everts P., Onishi K., Jayaram P. et al. Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020. Int J Mol Sci. 2020; 21 (20): 7794. DOI: 10.3390/ijms21207794
  7. Lana J.F., Macedo A., Ingrao I.L.G. et al. Leukocyte-rich PRP for knee osteoarthritis: Current concepts. J Clin Orthop Trauma. 2019; 10 (Suppl 1): S179–S182. DOI: 10.1016/j.jcot.2019.01.011
  8. Lin M.Y., Lin C.S., Hu S. et al. Progress in the Use of Platelet-rich Plasma in Aesthetic and Medical Dermatology. J Clin Aesthet Dermatol. 2020; 13 (8): 28–35.
  9. Kaushik A., Kumaran M.S. Platelet-Rich Plasma: The Journey so Far! Indian Dermatol Online J. 2020; 11 (5): 685–92. DOI: 10.4103/idoj.IDOJ_369_19
  10. Almohanna H.M., Ahmed A.A., Griggs J.W. et al. Platelet-Rich Plasma in the Treatment of Alopecia Areata: A Review. J Investig Dermatol Symp Proc. 2020; 20 (1): S45–S49. DOI: 10.1016/j.jisp.2020.05.002
  11. Gentile P., Garcovich S. Autologous activated platelet-rich plasma (AA-PRP) and non-activated (A-PRP) in hair growth: a retrospective, blinded, randomized evaluation in androgenetic alopecia. Expert Opin Biol Ther. 2020; 20 (3): 327–37. DOI: 10.1080/14712598.2020.1724951
  12. Ramadan W.M., Hassan A.M., Ismail M.A. et al. Evaluation of adding platelet-rich plasma to combined medical therapy in androgenetic alopecia. J Cosmet Dermatol. 2021; 20 (5): 1427–34. DOI: 10.1111/jocd.13935
  13. Чернопищук Р.Н. Использование плазмы, обогащенной тромбоцитами, при лечении ожогов в эксперименте. Новости хирургии. 2022; 30 (1): 5–11 [Chornopyshchuk R.N. The Use of Platelet-Rich Plasma in the Treatment of Burns in the Experiment. Novosti Khirurgii. 2022; 30 (1): 5–11 (in Russ.)]. DOI: 10.18484/2305-0047.2022.1.5
  14. Богданов С.Б., Иващук Ю.В., Бабичев Р.Г. и др. Хирургические аспекты выполнения пластики полнослойным аутотрансплантатом у больных с ожоговой травмой и ее последствиями. Мат-лы конф. «Оказание скорой медицинской и неотложной медицинской помощи раненым и пострадавшим при массовом поступлении». 2016; с. 66–7 [Bogdanov S.B., Ivashchuk Yu.V., Babichev R.G. et al. Khirurgicheskie aspekty vypolneniya plastiki polnosloinym autotransplantatom u bol'nykh s ozhogovoi travmoi i ee posledstviyami. Mat-ly konf. «Okazanie skoroi meditsinskoi i neotlozhnoi meditsinskoi pomoshchi ranenym i postradavshim pri massovom postuplenii». 2016; s. 66–7 (in Russ.)].
  15. Mehta M.A., Ranjan V., Kulkarni A.K., et al. Clinicoepidemiological study of post burn contractures at a tertiary care centre in western India. Int Surg J. 2019; 6(6): 1896–900. DOI: 10.18203/2349-2902.isj20192062
  16. Богослав Ю.П., Гюльмамедова И.Д., Ахмеров Р.Р. и др. Наш опыт применения технологии «Плазмолифтинг» (PlasmoliftingTM) в комплексном лечении бесплодия у женщин. Здоровье женщины. 2016; 9: 152–4 [Bogoslav Yu.P., Gulmamedova I.D., Ahmerov R.R. et al. Our experience of appying plasmolifting technology (PlasmoliftingTM) in treatment of infertility in women. Health of Woman. 2016; 9: 152–4 (in Russ.)]. DOI: 10.15574/HW.2016.115.152
  17. Бутрин Я.Л., Чмырев И.В. Сравнительная характеристика различных методов лечения глубоких ожогов лица. Вестник Российской военно-медицинской академии. 2017; 3: 56–62 [Butrin Ya.L., Chmyrev I.V. The comparative characteristics of different methods of treatment of deep burns of the face. Bulletin of the Russian Military Medical Academy. 2017; 3: 56–62 (in Russ.)].
  18. Singer A.J., Toussaint J., Choi W.T. et al. The effects of Platelet-rich Plasma on healing of partial thickness burns in a porcine model. Ann Burns Fire Disasters. 2018; 31 (4): 298–305.
  19. Sun Y., Cao Y., Zhao R. et al. The Role of Autologous PRP on Deep Partial-Thickness Burn Wound Healing in Bama Pigs. J Burn Care Res. 2020; 41 (3): 657–62. DOI: 10.1093/jbcr/iraa012
  20. Jaseem M., Alungal S., Dhiyaneswaran et al. Effectiveness of autologous PRP therapy in chronic nonhealing ulcer: A 2-year retrospective descriptive study. J Family Med Prim Care. 2020; 9 (6): 2818–22. DOI: 10.4103/jfmpc.jfmpc_177_20
  21. Huber S.C., de Moraes Martinelli B., Quintero M. et al. A case series of platelet rich plasma in chronic venous ulcers. Regen Ther. 2021; 18: 51–8. DOI: 10.1016/j.reth.2021.03.005
  22. Glynn L.G., Mustafa A., Casey M. et al. Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care. Pilot Feasibility Stud. 2018; 4: 93. DOI: 10.1186/s40814-018-0288-2
  23. Bennell K.L., Hunter D.J., Paterson K.L. Platelet-Rich Plasma for the Management of Hip and Knee Osteoarthritis. Curr Rheumatol Rep. 2017; 19 (5): 24. DOI: 10.1007/s11926-017-0652-x
  24. Rahimzadeh P., Imani F., Faiz S.H.R. et al. The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis. Clin Interv Aging. 2018; 13: 73–9. DOI: 10.2147/CIA.S147757
  25. Zhao J., Huang H., Liang G. et al. Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2020; 21 (1): 224. DOI: 10.1186/s12891-020-03262-w
  26. Madhi M.I., Yausep O.E., Khamdan K. et al. The use of PRP in treatment of Achilles Tendinopathy: A systematic review of literature. Study design: Systematic review of literature. Ann Med Surg (Lond). 2020; 55: 320–6. DOI: 10.1016/j.amsu.2020.04.042
  27. Hussein M., Hussein T. Effect of autologous platelet leukocyte rich plasma injections on atrophied lumbar multifidus muscle in low back pain patients with monosegmental degenerative disc disease. SICOT J. 2016; 2: 12. DOI: 10.1051/sicotj/2016002
  28. Бывальцев В.А., Калинин А.А., Оконешникова А.К. Сравнительный анализ эффективности применения PRP-терапии и фасетопластики у пациентов старшей возрастной группы с изолированным поясничным фасет-синдромом: отдаленные результаты рандомизированного контролируемого исследования. Успехи геронтологии. 2019; 32 (5): 804–11 [Byvaltsev V.A., Kalinin A.A., Okoneshnikova A.K. Comparative analysis of the effectiveness of PRP therapy and facetoplasty in older patients with isolated lumbar facet syndrome: long-term results of a randomized controlled trial. Adv Gerontol. 2019; 32 (5): 804–11 (in Russ.)].
  29. Gonçalves N.J.N., Frantz N., de Oliveira R.M. Platelet-rich plasma (PRP) therapy: An approach in reproductive medicine based on successful animal models. Anim Reprod. 2020; 16 (1): 93–8. DOI: 10.21451/1984-3143-AR2018-093
  30. Zadehmodarres S., Salehpour S., Saharkhiz N. et al. Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study. JBRA Assist Reprod. 2017; 21 (1): 54–6. DOI: 10.5935/1518-0557.20170013
  31. Molina A., Sánchez J., Sánchez W. et al. Platelet-rich plasma as an adjuvant in the endometrial preparation of patients with refractory endometrium. JBRA Assist Reprod. 2018; 22 (1): 42–8. DOI: 10.5935/1518-0557.20180009