Polymorphism of the APOE gene: prevalence of phenotypes in the population and an association with the development of Alzheimer's disease

DOI: https://doi.org/10.29296/25877305-2023-06-15
Issue: 
6
Year: 
2023

Professor A. Volobuyev, Biol.D; P. Romanchuk, Candidate of Medical Sciences; Associate Professor N. Romanchuk, Candidate of Medical Sciences; Professor
S. Krasnov, Biol.D; Professor I. Davydkin, MD
Samara State Medical University, Samara

Based on the Hardy–Weinberg theory and statistical studies, the authors analyzedthe prevalence of different APOE gene alleles in the populationto reveal the relatioship between the alelle structure of a phenotype and the risk for Alzheimer's disease. Based on the concept of dominant and recessive zygote structures of allelic polymorphism of the APOE gene, it was shown that there must be three phenotypes that determine the risk for Alzheimer's disease. The prevalence of these phenotypes in the human population was studied.
Keywords: 
chromosome
АРОЕ gene
nucleotide sequence
alleles
phenotype
genotype
Alzheimer‘s disease.

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