The relationship between vitamin D levels and the course of osteoarthritis in patients living in the Arctic Region

DOI: https://doi.org/10.29296/25877305-2022-11-11
Issue: 
11
Year: 
2022

M. Kashpanov(1); Professor V. Popov(2), MD; Professor I. Novikova(2), MD
1-Murmansk City Polyclinic Two
2-Northern State Medical University, Arkhangelsk

Twenty-nine patients with osteoarthritis (OA) were examined to identify the relationship between the level of vitamin D and the characteristics of the course of OA in patients residing in the Arctic Region. Vitamin D deficiency or insufficiency was detected in 82.8% of the examinees. In addition, a more obvious radiographic stage of OA, pain syndrome, signs of depression and anxiety, as well as greater dependence on outside help in everyday life were more commonly diagnosed in patients with OA and vitamin D deficiency/insufficiency..

Keywords: 
therapy
vitamin D
osteoarthritis



References: 
  1. Kabalyk M.A. Prevalence of osteoarthritis in Russia: regional aspects of trends in statistical parameters during 2011–2016. Rheumatology Science and Practice. 2018; 56 (4): 416–22 (in Russ.). DOI: 10.14412/1995-4484-2018-416-422
  2. Solonin Yu.G., Bojko E.R. Medical and physiological problems of the Arctic. Izvestiya Komi nauchnogo tsentra UrO RAN. 2017; 4 (32): 33–40 (in Russ.).
  3. Murmanskaya oblast' v tsifrakh. Statisticheskii sbornik. Murmansk: Federal'naya sluzhba gosudarstvennoi statistiki, Territorial'nyi organ Federal'noi sluzhby gosudarstvennoi statistiki po Murmanskoi oblasti, 2021; 127 р. (in Russ.).
  4. Armas L.A., Hollis B.W., Heaney R.P. Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004; 89 (11): 5387–91. DOI: 10.1210/jc.2004-0360
  5. Trang H.M., Cole D.E., Rubin L.A. et al. Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr. 1998; 68 (4): 854–8. DOI: 10.1093/ajcn/68.4.854
  6. Houghton L.A., Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. 2006; 84 (4): 694–7. DOI: 10.1093/ajcn/84.4.694
  7. Strukov V. I. Hypervitaminosis D and hypercalcemic conditions. When is calcium dangerous? Monograph? 2nd ed., revised. and additional. Penza: PGBOU DPO PIUV Minzdrava Rossii, 2014; 194 р. (in Russ.).