PREVENTION OF OBESITY AND SCLEROPOLYCYSTIS WITH THE USE OF DIETARY SUPPLEMENT SELENBIO FOR WOMEN
DOI: https://doi.org/10.29296/25877305-2022-03-07
Issue:
3
Year:
2022
The review of information on the role of the trace element selenium in lipid and carbohydrate
metabolism is carried out. The data of clinical studies of selenium, which showed the importance of selenium
deficiency in the pathogenesis of obesity and ovarian scleropolycystic disease, are presented. It has been
shown that the method of preventing obesity and ovarian scleropolycystic disease can be the use of a
biologically active supplement SELENBIO for women, obtained by biofortification of woolly-flowered
astragalus with L-selenocystine, due to which the drug has high bioavailability and low risk of toxic
effects.
Keywords:
obesity
carbohydrate metabolism
lipid metabolism
scleropolycystosis
selenium
SELEN BIO for women
References:
- Borisov V.V. Mikroelementy selen i tsink v organizme zhenschiny i muzhchiny: problemy i reshenija. Consilium Medicum. 2018; 20 (7): 63–8. DOI: 10.26442/2075-1753_2018.7.63-68
- Dedov D.V. Celen i selensoderzhaschie preparaty: znachenie dlja organizma i profilaktiki razlichnyh zabolevanij. Farmatsija. 2021; 70 (8): 54–7. DOI: 10.29296/25419218-2021-08-09
- Dedov D.V. Svidetel'stvo o gosudarstvennoj registratsii bazy dannyh №2019621591, Rossijskaja Federatsija. Dannye kompleksnogo klinicheskogo, instrumental'nogo i laboratornogo obsledovanija bol'nyh ishemicheskoj bolezn'ju serdtsa, ozhireniem i dislipidemiej: № 2019621478. Zajavl. 27.08.2019. Tverskoj gosudarstvennyj meditsinskij universitet Minzdrava Rossii.
- Dedov D.V., Koval'chuk A.N., El'gardt I.A. i dr. Vzaimosvjaz' klinicheskih harakteristik i pokazatelej remodelirovanija miokarda u bol'nyh ishemicheskoj bolezn'ju serdtsa i arterial'noj gipertenziej s soputstvujuschim ozhireniem. Evrazijskij kardiologicheskij zhurnal. 2019; S1: 159–60.
- Dedov D.V., Kolbasnikov S.V., Koval'chuk A.N. Svidetel'stvo o gosudarstvennoj registratsii bazy dannyh №2021620072, Rossijskaja Federatsija. Dannye kompleksnogo kliniko-instrumental'nogo obsledovanija bol'nyh ishemicheskoj bolezn'ju serdtsa i saharnym diabetom. № 2020622814. Zajavl. 25.12.2020. Tverskoj gosudarstvennyj meditsinskij universitet» Ministerstva zdravoohranenija Rossijskoj Federatsii.
- Dedov D.V., Mazaev V.P., El'gardt I.A. i dr. Vzaimosvjaz' ozhirenija i arterial'noj gipertenzii kak osnovnyh faktorov riska u bol'nyh ishemicheskoj bolezn'ju serdtsa – zhitelej Tverskoj oblasti. Kardiovaskuljarnaja terapija i profilaktika. 2017; 16 (S3): 102–3.
- Polubojarinov P.A. Issledovanie biofortifikatsii rastenij astragala Astragala sherstistotsvetkovogo (Astragalus dasyanthus Pall.) aminokislotoj L-selenotsisteinom. Voprosy biologicheskoj, meditsinskoj i farmatsevticheskoj himii. 2019; 22 (12): 64.
- Polubojarinov P.A., Elistratov D.G., Shvets V.I. Metabolizm i mehanizm toksichnosti selensoderzhaschih preparatov, ispol'zuemyh dlja korrektsii defitsita mikroelementa selena. Tonkie himicheskie tehnologii. 2019; 14 (1): 5–24. DOI: 10.32362/2410-6593-2019-14-1-5-24
- Banach W., Nitschke K., Krajewska N. et al. The Association between Excess Body Mass and Disturbances in Somatic Mineral Levels. Int J Mol Sci. 2020; 21 (19): 7306. DOI: 10.3390/ijms21197306
- Cavedon E., Manso J., Negro I. et al. Selenium Supplementation, Body Mass Composition, and Leptin Levels in Patients with Obesity on a Balanced Mildly Hypocaloric Diet: A Pilot Study. Int J Endocrinol. 2020; 2020: 4802739. DOI: 10.1155/2020/4802739
- Coskun A., Arikan T., Kilinc M. et al. Plasma selenium levels in Turkish women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2013; 168 (2): 183–6. DOI: 10.1016/j.ejogrb.2013.01.021
- Engin A.B. Adipocyte-Macrophage Cross-Talk in Obesity. Adv Exp Med Biol. 2017; 960: 327–43. DOI: 10.1007/978-3-319-48382-5_14
- Fontenelle L.C., Feitosa M.M., Freitas T.E.C. et al. Selenium status and its relationship with thyroid hormones in obese women. Clin Nutr ESPEN. 2021; 41: 398–404. DOI: 10.1016/j.clnesp.2020.10.012
- Gać P., Czerwińska K., Macek P. et al. The importance of selenium and zinc deficiency in cardiovascular disorders. Environ Toxicol Pharmacol. 2021; 82: 103553. DOI: 10.1016/j.etap.2020.103553
- Heidar Z., Hamzepour N., Modarres S.Z. et al. The Effects of Selenium Supplementation on Clinical Symptoms and Gene Expression Related to Inflammation and Vascular Endothelial Growth Factor in Infertile Women Candidate for In Vitro Fertilization. Biol Trace Elem Res. 2020; 193 (2): 319–25. DOI: 10.1007/s12011-019-01715-5
- Hosseini B., Saedisomeolia A., Allman-Farinelli M. Association Between Antioxidant Intake/Status and Obesity: a Systematic Review of Observational Studies. Biol Trace Elem Res. 2017; 175 (2): 287–97. DOI: 10.1007/s12011-016-0785-1
- Huang X., Dong Y.L., Li T. et al. Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress. Nutrients. 2021; 13 (5): 1527. DOI: 10.3390/nu13051527
- Jacobs E.T., Lance P., Mandarino L.J. et al. Selenium supplementation and insulin resistance in a randomized, clinical trial. BMJ Open Diabetes Res Care. 2019; 7 (1): e000613. DOI: 10.1136/bmjdrc-2018-000613
- Jamilian M., Razavi M., Fakhrie Kashan Z. et al. Metabolic response to selenium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf). 2015; 82 (6): 885–91. DOI: 10.1111/cen.12699
- Jankovic A., Korac A., Buzadzic B. et al. Redox implications in adipose tissue (dys)function-A new look at old acquaintances. Redox Biol. 2015; 6: 19–32. DOI: 10.1016/j.redox.2015.06.018
- Köse S.A., Naziroğlu M. Selenium reduces oxidative stress and calcium entry through TRPV1 channels in the neutrophils of patients with polycystic ovary syndrome. Biol Trace Elem Res. 2014; 158 (2): 136–42. DOI: 10.1007/s12011-014-9929-3
- Manna P., Jain S.K. Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metab Syndr Relat Disord. 2015; 13: 423–44. DOI: 10.1089/met.2015.0095
- Nido S.A., Shituleni S.A., Mengistu B.M. et al. Effects of Selenium-Enriched Probiotics on Lipid Metabolism, Antioxidative Status, Histopathological Lesions, and Related Gene Expression in Mice Fed a High-Fat Diet. Biol Trace Elem Res. 2016; 171 (2): 399–409. DOI: 10.1007/s12011-015-0552-8
- Ojeda M.L., Herrera I., Nogales F. et al. Fetal rrogramming is deeply related to vaternal selenium status and oxidative balance; experimental offspring health repercussions. Nutrients. 2021; 13 (6): 2085. DOI: 10.3390/nu13062085
- Pieczynska J., Grajeta H. The role of selenium in human conception and pregnancy. J Trace Elem Med Biol. 2015; 29 (1): 31–8. DOI: 10.1016/j.jtemb.2014.07.003
- Qazi I.H., Angel C., Yang H. et al. Selenium, Selenoproteins, and Female Reproduction: A Review. Molecules. 2018; 23 (12): 3053. DOI: 10.3390/molecules23123053
- Rashidi B.H., Mohammad. Hosseinzadeh F. et al. Effects of Selenium Supplementation on Asymmetric Dimethylarginine and Cardiometabolic Risk Factors in Patients with Polycystic Ovary Syndrome. Biol Trace Elem Res. 2020; 196 (2): 430–7. DOI: 10.1007/s12011-019-01954-6
- Razavi M., Jamilian M., Kashan Z.F. et al. Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome. Horm Metab Res. 2016; 48 (3): 185–90. DOI: 10.1055/s-0035-1559604
- Santos A.C., Passos A.F.F., Holzbach L.C. et al. Selenium Intake and Glycemic Control in Young Adults With Normal-Weight Obesity Syndrome. Front Nutr. 2021; 8: 696325. DOI: 10.3389/fnut.2021.696325
- Seale L.A. Selenocysteine β-Lyase: Biochemistry, Regulation and Physiological Role of the Selenocysteine Decomposition Enzyme. Antioxidants (Basel). 2019; 8 (9): 357. DOI: 10.3390/antiox8090357
- Shahidi F., De Camargo A.C. Tocopherols and tocotrienols in common and emerging dietary sources: Occurrence, applications, and health benefits. Int J Mol Sci. 2016; 17 (10): 1745. DOI: 10.3390/ijms17101745
- Shimada B.K., Alfulaij N., Seale L.A. The Impact of Selenium Deficiency on Cardiovascular Function. Int J Mol Sci. 2021; 22 (19): 10713. DOI: 10.3390/ijms221910713
- Soares de Oliveira A.R., Jayanne Climaco Cruz K., Beatriz Silva Morais J. et al. Selenium status and oxidative stress in obese: Influence of adiposity. Eur J Clin Invest. 2021; 51 (9): e13538. DOI: 10.1111/eci.13538
- Steinbrenner H. Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism. Free Radic Biol Med. 2013; 65: 1538–47. DOI: 10.1016/j.freeradbiomed.2013.07.016
- Steyn M., Zitouni K., Kelly F.J. et al. Sex Differences in Glutathione Peroxidase Activity and Central Obesity in Patients with Type 2 Diabetes at High Risk of Cardio-Renal Disease. Antioxidants (Basel). 2019; 8 (12): 629. DOI: 10.3390/antiox8120629
- Suganami T., Ogawa Y. Adipose tissue macrophages: their role in adipose tissue remodeling. J Leukoc Biol. 2010; 88 (1): 33–9. DOI: 10.1189/jlb.0210072
- Szczuko M., Zapalowska-Chwyć M., Drozd R. A Low Glycemic Index Decreases Inflammation by Increasing the Concentration of Uric Acid and the Activity of Glutathione Peroxidase (GPx3) in Patients with Polycystic Ovary Syndrome (PCOS). Molecules. 2019; 24 (8): 1508. DOI: 10.3390/molecules24081508
- Torres D.J., Pitts M.W., Hashimoto A.C. et al. Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance. Nutrients. 2019; 11: 1693. DOI: 10.3390/nu11071693
- Touat-Hamici Z., Legrain Y., Bulteau A.L. et al. Selective up-regulation of human selenoproteins in response to oxidative stress. J Biol Chem. 2014; 289 (21): 14750–61. DOI: 10.1074/jbc.M114.551994
- Tun S., Spainhower C.J., Cottrill C.L. et al. Therapeutic Efficacy of Antioxidants in Ameliorating Obesity Phenotype and Associated Comorbidities. Front Pharmacol. 2020; 13 (11): 1234. DOI: 10.3389/fphar.2020.01234
- Vinceti M., Filippini T., Rothman K.J. Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis. Eur J Epidemiol. 2018; 33 (9): 789–810. DOI: 10.1007/s10654-018-0422-8
- Wang Y., Gao X., Pedram P. et al. Significant Beneficial Association of High Dietary Selenium Intake with Reduced Body Fat in the CODING Study. Nutrients. 2016; 8 (1): 24. DOI: 10.3390/nu8010024
- Zagrodzki P., Krzyczkowska-Sendrakowska M., Nicol F. et al. Selenium status parameters in patients with polycystic ovary syndrome. J Trace Elem Med Biol. 2017; 44: 241–6. DOI: 10.1016/j.jtemb.2017.08.012
- Zhang Q., Qian Z.Y., Zhou P.H. et al. Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet. Lipids Health Dis. 2018; 17 (1): 165. DOI: 10.1186/s12944-018-0815-4
- Zhao H., Li K., Tang J.Y. et al. Expression of Selenoprotein Genes Is Affected by Obesity of Pigs Fed a High-Fat Diet. J Nutr. 2015; 145 (7): 1394–401. DOI: 10.3945/jn.115.211318
- Zhong Q., Lin R., Nong Q. Adiposity and Serum Selenium in U.S. Adults. Nutrients. 2018; 10 (6): 727. DOI: 10.3390/nu10060727
- Borisov V.V. Microelements selenium and zinc in female and male body: problems and solutions. Consilium Medicum. 2018; 20 (7): 63–8 (in Russ.). DOI: 10.26442/2075-1753_2018.7.63-68
- Dedov D.V. Selenium and selenium-containing drugs: importance for the body and prevention of various diseases. Pharmacy. 2021; 70 (8): 54–7 (in Russ.). DOI: 10.29296/25419218-2021-08-09
- Dedov D.V. Certificate of State Registration of Database No. 2019621591 Russian Federation. Data from comprehensive clinical, instrumental, and laboratory examination of patients with coronary heart disease, obesity, and dyslipidemia. no. 2019621478. Tver State Medical University (in Russ.).
- Dedov D.V., Kovalchuk A.N., Elgardt I.A. et al. Relationship of clinical characteristics and indicators of myocardial remodeling in patients with coronary heart disease and hypertension with concomitant obesity. Eurasian heart journal. 2019; S1: 159–60 (in Russ.).
- Dedov D.V., Kolbasnikov S.V., Kovalchuk A.N. Certificate of state registration of the database No2021620072 Russian Federation. Data of complex clinical and instrumental examination of patients with coronary heart disease and diabetes mellitus: No. 2020622814: application. December 25, 2020. Tver State Medical (in Russ.).
- Dedov D.V., Mazaev V.P., Elgardt I.A. et al. Interrelation of obesity and arterial hypertension as the main risk factors in patients with coronary heart disease – residents of Tver region. Cardiovascular Therapy and Prevention. 2017; 16 (S3): 102–3 (in Russ.).
- Poluboyarinov P.A. Biofortification of Astragalus astragalus woolly-flowered (Astragalus dasyanthus Pall.) plants with the amino acid L-selenocysteine. Problems of biological, medical and pharmaceutical chemistry. 2019; 22 (12): 64 (in Russ.).
- Poluboyarinov P.A., Elistratov D.G., Shvets V.I. Metabolism and mechanism of toxicity of selenium-containing supplements used for optimizing human selenium status. Fine Chemical Technologies. 2019; 14 (1): 5–24 (in Russ.). DOI: 10.32362/2410-6593-2019-14-1-5-24
- Banach W., Nitschke K., Krajewska N. et al. The Association between Excess Body Mass and Disturbances in Somatic Mineral Levels. Int J Mol Sci. 2020; 21 (19): 7306. DOI: 10.3390/ijms21197306
- Cavedon E., Manso J., Negro I. et al. Selenium Supplementation, Body Mass Composition, and Leptin Levels in Patients with Obesity on a Balanced Mildly Hypocaloric Diet: A Pilot Study. Int J Endocrinol. 2020; 2020: 4802739. DOI: 10.1155/2020/4802739
- Coskun A., Arikan T., Kilinc M. et al. Plasma selenium levels in Turkish women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2013; 168 (2): 183–6. DOI: 10.1016/j.ejogrb.2013.01.021
- Engin A.B. Adipocyte-Macrophage Cross-Talk in Obesity. Adv Exp Med Biol. 2017; 960: 327–43. DOI: 10.1007/978-3-319-48382-5_14
- Fontenelle L.C., Feitosa M.M., Freitas T.E.C. et al. Selenium status and its relationship with thyroid hormones in obese women. Clin Nutr ESPEN. 2021; 41: 398–404. DOI: 10.1016/j.clnesp.2020.10.012
- Gać P., Czerwińska K., Macek P. et al. The importance of selenium and zinc deficiency in cardiovascular disorders. Environ Toxicol Pharmacol. 2021; 82: 103553. DOI: 10.1016/j.etap.2020.103553
- Heidar Z., Hamzepour N., Modarres S.Z. et al. The Effects of Selenium Supplementation on Clinical Symptoms and Gene Expression Related to Inflammation and Vascular Endothelial Growth Factor in Infertile Women Candidate for In Vitro Fertilization. Biol Trace Elem Res. 2020; 193 (2): 319–25. DOI: 10.1007/s12011-019-01715-5
- Hosseini B., Saedisomeolia A., Allman-Farinelli M. Association Between Antioxidant Intake/Status and Obesity: a Systematic Review of Observational Studies. Biol Trace Elem Res. 2017; 175 (2): 287–97. DOI: 10.1007/s12011-016-0785-1
- Huang X., Dong Y.L., Li T. et al. Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress. Nutrients. 2021; 13 (5): 1527. DOI: 10.3390/nu13051527
- Jacobs E.T., Lance P., Mandarino L.J. et al. Selenium supplementation and insulin resistance in a randomized, clinical trial. BMJ Open Diabetes Res Care. 2019; 7 (1): e000613. DOI: 10.1136/bmjdrc-2018-000613
- Jamilian M., Razavi M., Fakhrie Kashan Z. et al. Metabolic response to selenium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf). 2015; 82 (6): 885–91. DOI: 10.1111/cen.12699
- Jankovic A., Korac A., Buzadzic B. et al. Redox implications in adipose tissue (dys)function-A new look at old acquaintances. Redox Biol. 2015; 6: 19–32. DOI: 10.1016/j.redox.2015.06.018
- Köse S.A., Naziroğlu M. Selenium reduces oxidative stress and calcium entry through TRPV1 channels in the neutrophils of patients with polycystic ovary syndrome. Biol Trace Elem Res. 2014; 158 (2): 136–42. DOI: 10.1007/s12011-014-9929-3
- Manna P., Jain S.K. Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metab Syndr Relat Disord. 2015; 13: 423–44. DOI: 10.1089/met.2015.0095
- Nido S.A., Shituleni S.A., Mengistu B.M. et al. Effects of Selenium-Enriched Probiotics on Lipid Metabolism, Antioxidative Status, Histopathological Lesions, and Related Gene Expression in Mice Fed a High-Fat Diet. Biol Trace Elem Res. 2016; 171 (2): 399–409. DOI: 10.1007/s12011-015-0552-8
- Ojeda M.L., Herrera I., Nogales F. et al. Fetal rrogramming is deeply related to vaternal selenium status and oxidative balance; experimental offspring health repercussions. Nutrients. 2021; 13 (6): 2085. DOI: 10.3390/nu13062085
- Pieczynska J., Grajeta H. The role of selenium in human conception and pregnancy. J Trace Elem Med Biol. 2015; 29 (1): 31–8. DOI: 10.1016/j.jtemb.2014.07.003
- Qazi I.H., Angel C., Yang H. et al. Selenium, Selenoproteins, and Female Reproduction: A Review. Molecules. 2018; 23 (12): 3053. DOI: 10.3390/molecules23123053
- Rashidi B.H., Mohammad. Hosseinzadeh F. et al. Effects of Selenium Supplementation on Asymmetric Dimethylarginine and Cardiometabolic Risk Factors in Patients with Polycystic Ovary Syndrome. Biol Trace Elem Res. 2020; 196 (2): 430–7. DOI: 10.1007/s12011-019-01954-6
- Razavi M., Jamilian M., Kashan Z.F. et al. Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome. Horm Metab Res. 2016; 48 (3): 185–90. DOI: 10.1055/s-0035-1559604
- Santos A.C., Passos A.F.F., Holzbach L.C. et al. Selenium Intake and Glycemic Control in Young Adults With Normal-Weight Obesity Syndrome. Front Nutr. 2021; 8: 696325. DOI: 10.3389/fnut.2021.696325
- Seale L.A. Selenocysteine β-Lyase: Biochemistry, Regulation and Physiological Role of the Selenocysteine Decomposition Enzyme. Antioxidants (Basel). 2019; 8 (9): 357. DOI: 10.3390/antiox8090357
- Shahidi F., De Camargo A.C. Tocopherols and tocotrienols in common and emerging dietary sources: Occurrence, applications, and health benefits. Int J Mol Sci. 2016; 17 (10): 1745. DOI: 10.3390/ijms17101745
- Shimada B.K., Alfulaij N., Seale L.A. The Impact of Selenium Deficiency on Cardiovascular Function. Int J Mol Sci. 2021; 22 (19): 10713. DOI: 10.3390/ijms221910713
- Soares de Oliveira A.R., Jayanne Climaco Cruz K., Beatriz Silva Morais J. et al. Selenium status and oxidative stress in obese: Influence of adiposity. Eur J Clin Invest. 2021; 51 (9): e13538. DOI: 10.1111/eci.13538 Steinbrenner H. Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism. Free Radic Biol Med. 2013; 65: 1538–47. DOI: 10.1016/j.freeradbiomed.2013.07.016
- Steyn M., Zitouni K., Kelly F.J. et al. Sex Differences in Glutathione Peroxidase Activity and Central Obesity in Patients with Type 2 Diabetes at High Risk of Cardio-Renal Disease. Antioxidants (Basel). 2019; 8 (12): 629. DOI: 10.3390/antiox8120629
- Suganami T., Ogawa Y. Adipose tissue macrophages: their role in adipose tissue remodeling. J Leukoc Biol. 2010; 88 (1): 33–9. DOI: 10.1189/jlb.0210072
- Szczuko M., Zapalowska-Chwyć M., Drozd R. A Low Glycemic Index Decreases Inflammation by Increasing the Concentration of Uric Acid and the Activity of Glutathione Peroxidase (GPx3) in Patients with Polycystic Ovary Syndrome (PCOS). Molecules. 2019; 24 (8): 1508. DOI: 10.3390/molecules24081508
- Torres D.J., Pitts M.W., Hashimoto A.C. et al. Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance. Nutrients. 2019; 11: 1693. DOI: 10.3390/nu11071693
- Touat-Hamici Z., Legrain Y., Bulteau A.L. et al. Selective up-regulation of human selenoproteins in response to oxidative stress. J Biol Chem. 2014; 289 (21): 14750–61. DOI: 10.1074/jbc.M114.551994
- Tun S., Spainhower C.J., Cottrill C.L. et al. Therapeutic Efficacy of Antioxidants in Ameliorating Obesity Phenotype and Associated Comorbidities. Front Pharmacol. 2020; 13 (11): 1234. DOI: 10.3389/fphar.2020.01234
- Vinceti M., Filippini T., Rothman K.J. Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis. Eur J Epidemiol. 2018; 33 (9): 789–810. DOI: 10.1007/s10654-018-0422-8
- Wang Y., Gao X., Pedram P. et al. Significant Beneficial Association of High Dietary Selenium Intake with Reduced Body Fat in the CODING Study. Nutrients. 2016; 8 (1): 24. DOI: 10.3390/nu8010024
- Zagrodzki P., Krzyczkowska-Sendrakowska M., Nicol F. et al. Selenium status parameters in patients with polycystic ovary syndrome. J Trace Elem Med Biol. 2017; 44: 241–6. DOI: 10.1016/j.jtemb.2017.08.012
- Zhang Q., Qian Z.Y., Zhou P.H. et al. Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet. Lipids Health Dis. 2018; 17 (1): 165. DOI: 10.1186/s12944-018-0815-4
- Zhao H., Li K., Tang J.Y. et al. Expression of Selenoprotein Genes Is Affected by Obesity of Pigs Fed a High-Fat Diet. J Nutr. 2015; 145 (7): 1394–401. DOI: 10.3945/jn.115.211318
- Zhong Q., Lin R., Nong Q. Adiposity and Serum Selenium in U.S. Adults. Nutrients. 2018; 10 (6): 727. DOI: 10.3390/nu10060727