Повышение концентрации кардиоспецифичных тропонинов при отсутствии инфаркта миокарда. Часть 2
DOI: https://doi.org/10.29296/25877305-2020-04-07
Номер журнала:
4
Год издания:
2020
Во 2-й части обзора (часть 1-ю см. в журнале «Врач» №3, 2020) рассматриваются механизмы повышения и диагностическая ценность кардиальных изоформ тропонинов при физической нагрузке, тахиаритмиях, использовании кардиотоксических препаратов (химиотерапия), цереброваскулярных заболеваниях, сепсисе, скелетных миопатиях, расслаивающей аневризме аорты и почечной недостаточности. Кроме того, обсуждаются основные факторы, вызывающие ложноположительное повышение уровня сердечных тропонинов: гетерофильные антитела, ревматоидный фактор, щелочная фосфатаза.
Ключевые слова:
кардиология
сердечные тропонины
физическая нагрузка
сепсис
кардиотоксичность
инсульт
расслаивающая аневризма аорты
почечная недостаточность
скорость клубочковой фильтрации
ложноположительные результаты
Для цитирования
А.М. Чаулин, Л.С. Карслян, А.Г. Александров, Д.В. Дупляков Повышение концентрации кардиоспецифичных тропонинов при отсутствии инфаркта миокарда. Часть 2
. Врач, 2020; (4): 38-45 https://doi.org/10.29296/25877305-2020-04-07Список литературы:
- Roffi M., Patrono C., Collet J. et al. ESC Scientific Document Group. 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European society of cardio-logy (ESC) // Eur. Heart J. – 2016; 37 (3): 267–315. https://doi.org/10.1093/eurheartj/ehv320
- Lim W., Qushmaq I., Devereaux P. et al. Elevated cardiac troponin measurements in critically ill patients // Arch. Intern. Med. – 2006; 166 (22): 2446–54. https://doi.org/10.1001/archinte.166.22.2446
- Richardson A., Leckie T., Watkins E. et al. Post marathon cardiac troponin T is associated with relative exercise intensity// J. Sci Med. Sport. – 2018; 21 (9): 880–4. https://doi.org/10.1016/j.jsams.2018.02.005
- Samaha E., Brown J., Brown F. et al. High-sensitive cardiac troponin T increases after stress echocardiography // Clin. Biochem. – 2019; 63: 18–23. https://doi.org/10.1016/j.clinbiochem.2018.11.013
- Manjunath L., Yeluru A., Rodriguez F. 27-Year-Old Man with a Positive Troponin: A Case Report // Cardiol. Ther. – 2018; 7 (2): 197–204. https://doi.org/10.1007/s40119-018-0120-3
- Bukkapatnam R., Robinson M., Turnipseed S. et al. Relationship of myocardial ischemia and injury to coronary artery disease in patients with supraventricular tachycardia // Am. J. Cardiol. – 2010; 106 (3): 374–7. DOI: 10.1016/j.amjcard.2010.03.035
- Ben Yedder N., Roux J., Paredes F. Troponin elevation in supraventricular tachycardia: primary dependence on heart rate // Can. J. Cardiol. – 2011; 27 (1): 105–9. DOI: 10.1016/j.cjca.2010.12.004.
- Kumar A., Paladugu B., Mensing J. et al. Transforming growth factor-beta 1 blocks in vitro cardiac myocyte depression induced by tumour necrosis factor-alpha, interleukin-1 beta, and human septic shock serum // Crit. Care Med. – 2007;35 (2): 358–64. DOI: 10.1097/01.CCM.0000254341.87098.A4
- Rosjo H., Varpula M., Hagve T. et al. Circulating high-sensitive troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome // Int. Care Med. – 2011; 37 (1): 77–85. https://doi.org/10.1007/s00134-010-2051-x
- Крикунова О.В., Васюк Ю.А., Висков Р.В. и др. Сердечные тропонины в выявлении кардиотоксичности у пациентов, подвергающихся химиотерапии // Российский кардиологический журнал. – 2015; 20 (12): 119–25. [Krikunova O.V., Vasyuk Yu.A., Viskov R.V. et al. Chemotherapy cardiotoxicity screening with cardiac troponins // Rossiyskiy kardiologicheskiy zhurnal (Russian Journal of Cardiology). – 2015; 20 (12): 119–25 (in Russ.)]. https://doi.org/10.15829/1560-4071-2015-12-119-125
- Jones M., O’Gorman P., Kelly C. et al. High-sensitive cardiac troponin-I facilitates timely detection of subclinical anthracycline-mediated cardiac injury // Ann. Clin. Biochem. – 2017; 54 (1): 149–57. https://doi.org/10.1177/0004563216650464
- Jaffe A., Vasile V., Milone M. et al. Diseased skeletal muscle: a noncardiac sourse of increased circulating concentrations of cardiac troponin T // J. Am. Coll. Cardiol. – 2011; 58 (17): 1819–24. DOI: 10.1016/j.jacc.2011.08.026
- Rittoo D., Jones A., Lecky B. et al. Elevation of cardiac troponin T, but not cardiac troponin I, in patients with neuromuscular diseases: implications for the diagnosis of myocardial infarction // J. Am. Coll. Cardiol. – 2014; 63 (22): 2411–20. DOI: 10.1016/j.jacc.2014.03.027
- Schmid J., Liesinger L., Birner-Gruenberger R. et al. Elevated Cardiac Troponin T in Patients With Skeletal Myopathies // J. Am. Coll. Cardiol. – 2018; 71 (14): 1540–9. DOI: 10.1016/j.jacc.2018.01.070
- Kerr G., Ray G., Wu O. et al. Elevated troponin after stroke: a systematic review // Cerebrovasc. Dis. – 2009; 28 (3): 220–6. DOI: 10.1159/000226773
- Barber M., Morton J., Macfarlane P. et al. Elevated troponin levels are associated with sympathoadrenal activation in acute ischaemic stroke // Cerebrovasc. Dis. – 2007; 23 (4): 260–6. DOI: 10.1159/000098325
- Sandhu R., Aronow W., Rajdev A. et al. Relation of cardiac troponin I levels with in-hospital mortality in patients with ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage // Am. J. Cardiol. – 2008; 102 (5): 632–4. DOI: 10.1016/j.amjcard.2008.04.036.
- Ryden L., Roos A., Holzmann M. Chronic myocardial injury and risk for stroke // Am. J. Med. – 2019; 132 (7): 833–9. DOI: 10.1016/j.amjmed.2019.01.027
- Vrsalovic M. Prognostic effect of cardiac troponin elevation in acute aortic dissection: a meta-analysis // Int. J. Cardiol. – 2016; 214: 277– 80. DOI: 10.1016/j.ijcard.2016.03.230
- Chenevier-Gobeaux C., Meune C., Freund Y. et al. Influence of age and renal function on high-sensitivity cardiac troponin T diagnostic accuracy for the diagnosis of acute myocardial infarction // Am. J. Cardiol. – 2013; 111 (12): 1701–7. https://doi.org/10.1016/j.amjcard.2013.02.024
- Dubin R., Li Y., He J. et al. Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC) // BMC Nephrol. – 2013; 14: 229. https://doi.org/10.1186/1471-2369-14-229
- Ellis K., Dreisbach A., Lertora J. Plasma elimination of cardiac troponin I in end-stage renal disease // South. Med. J. – 2001; 94 (10): 993–6. https://doi.org/10.1097/00007611-200194100-00011
- Ziebig R., Lun A., Hocher B. et al. Renal elimination of troponin T and troponin I // Clin. Chem. – 2003; 49 (7): 1191–3. https://doi.org/10.1373/49.7.1191
- Pervan P., Svagusa T., Prkacin I. et al. Urine high-sensitive troponin I measuring in patients with hypertension // Signa Vitae. – 2017; 13 (3): 62–4. https://doi.org/10.22514/sv133.062017.13
- Freda B., Tang W., Van Lente F. et al. Cardiac troponins in renal insufficiency: review and clinical implications // J. Am. Coll. Cardiol. – 2002; 40 (12): 2065–71. https://doi.org/10.1016/s0735-1097(02)02608-6
- Antman E., Grudzien C., Mitchell R. et al. Detection of unsuspected myocardial necrosis by rapid bedside assay for cardiac troponin T // Am. Heart J. – 1997; 133 (5): 596–8. https://doi.org/10.1016/s0002-8703(97)70156-x
- Ooi D., Isotalo P., Veinot J. Correlation of antemortem serum creatine kinase, creatine kinase-MB, troponin I, and troponin T with cardiac pathology // Clin. Chem. – 2000; 46 (3): 338–44.
- Ricchiutti V., Apple F. RNA expression of cardiac troponin T isoforms in diseased human skeletal muscle // Clin. Chem. – 1999; 45 (12): 2129–35. https://www.ncbi.nlm.nih.gov/pubmed/10585344
- Anderson P., Malouf N., Oakeley A. et al. Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle // Circ. Res. – 1991; 69 (5): 1226–33. https://doi.org/10.1161/01.res.69.5.1226
- Zumrutdal A., Bakinen O., Ucan H. et al. Relationship between uremic myopathy and false-positive cardiac troponin T test // Nephron. – 2000; 86 (4): 522–3. https://doi.org/10.1159/000045852
- Haller C., Zehelein J., Remppis A. et al. Cardiac troponin T in patients with end stage renal disease: Absence of expression in truncal skeletal muscle // Clin Chem. – 1998; 44 (5): 930–8. https://www.ncbi.nlm.nih.gov/pubmed/9590364
- Khan N., Hemmelgarn B., Tonelli M. et al. Prognostic value of troponin T and I among asymptomatic patients with end-stage renal disease: a meta-analysis // Circulation. – 2005; 112 (20): 3088–96. https://doi.org/10.1161/circulationaha.105.560128
- Bjurman C., Petzold M., Venge P. et al. High-sensitive cardiac troponin, NT-proBNP, hFABP and copeptin levels in relation to glomerular filtration rates and a medical record of cardiovascular disease // Clin. Biochem. – 2015; 48 (4–5): 302–7. https://doi.org/10.1016/j.clinbiochem.2015.01.008
- Twerenbold R., Wildi K., Jaeger C. et al. Optimal cutoff levels of more sensitive cardiac troponin assays for the early diagnosis of myocardial infarction in patients with renal dysfunction // Circulation. – 2015; 131 (23): 2041–50. https://doi.org/10.1161/circulationaha.114.014245
- Kavsak P., Worster A., Shortt C. et al. Performance of high-sensitivity cardiac troponin in the emergency department for myocardial infarction and a composite cardiac outcome across different estimated glomerular filtration rates // Clin. Chim. Acta. – 2018; 479: 166–70. https://doi.org/10.1016/j.cca.2018.01.034
- Lippi G., Aloe R., Meschi T. et al. Interference from heterophilic antibodies in troponin testing. Case report and systematic review of the literature // Clin. Chim. Acta. – 2013; 426: 79–84. doi: 10.1016/j.cca.2013.09.004
- Lum G., Solarz D., Farney L. False positive cardiac troponin results in patients without acute myocardial infarction // Laboratory Medicine. – 2006; 37 (9): 546–50. https://doi.org/10.1309/T94UUXTJ3TX5Y9W2
- Al-Awadhi A., Olusi S., Hasan E. et al. Serum concentrations of cardiac troponin-I in patients with rheumatoid arthritis, systemic lupus erythematosus, primary Sjogren’s syndrome and Graves’ disease // Singapore Med. J. – 2007; 48 (9): 847–9. https://www.ncbi.nlm.nih.gov/pubmed/17728967
- Dasgupta A., Chow L., Wells A. et al. Effect of elevated concentration of alkaline phosphatase on cardiac troponin I assays // J. Clin. Lab. Anal. – 2001; 15 (4): 175–7. DOI: 10.1002/jcla.1023
- Marinheiro R., Amador P., Parreira L. et al. False Positive Troponin I Rendering Two Admissions for «Recurrent Acute Myopericarditis» // Open Cardiovasc. Med. J. – 2018; 12: 55–8. doi: 10.2174/1874192401812010055