Современная стратегия лечения фибрилляции предсердий: трудный путь к «доказательству аксиомы»

DOI: https://doi.org/10.29296/25877305-2022-07-02
Номер журнала: 
7
Год издания: 
2022

С.Г. Канорский, доктор медицинских наук, профессор
Кубанский государственный медицинский университет, Краснодар
E-mail: kanorskysg@mail.ru

Фибрилляция предсердий (ФП) снижает работоспособность пациентов, а также повышает уровень заболеваемости и смертности. В исследованиях, завершившихся в начале XXI в., не удалось установить преимущества стратегии лечения ФП, направленной на восстановление и поддержание синусового ритма, в сравнении со стратегией урежения частоты желудочковых сокращений при сохраняющейся ФП. Вследствие чего на протяжении двух десятилетий в терапии пациентов с ФП предпочтительным был отказ от восстановления синусового ритма. Совершенствование медикаментозной терапии и методов катетерной аблации позволяют снижать риск неблагоприятных сердечно-сосудистых исходов с помощью стратегии раннего контроля синусового ритма при ФП. В обзоре представлены наиболее интересные результаты современных клинических исследований и рекомендации в отношении различных способов лечения ФП, данные об эффективности и безопасности антиаритмической лекарственной терапии, катетерной аблации, в том числе полученные при их непосредственном сравнении. Обсуждены проблемы применения стратегии контроля синусового ритма у пациентов с ФП и сердечной недостаточностью, риск и выгода лечения антиаритмическими препаратами IC и III классов. В будущем широкое применение активно развивающейся терапии с целью контроля синусового ритма поможет пациентам с ФП снизить тяжесть симптомов и частоту осложнений данной аритмии.

Ключевые слова: 
кардиология
фибрилляция предсердий
антиаритмические препараты
катетерная аблация
контроль синусового ритма

Для цитирования
Канорский С.Г. Современная стратегия лечения фибрилляции предсердий: трудный путь к «доказательству аксиомы» . Врач, 2022; (7): 9-17 https://doi.org/10.29296/25877305-2022-07-02


Список литературы: 
  1. Tsao C.W., Aday A.W., Almarzooq Z.I. et al. Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association. Circulation. 2022; 145 (8): e153–e639. DOI: 10.1161/CIR.0000000000001052
  2. Nattel S., Sager P.T., Hüser J. et al. Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it. Cardiovasc Res. 2021; 117 (7): 1616–31. DOI: 10.1093/cvr/cvab093
  3. Hindricks G., Potpara T., Dagres N. et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021; 42 (5): 373–498. DOI: 10.1093/eurheartj/ehaa612
  4. Camm A.J., Naccarelli G.V., Mittal S. et al. The Increasing Role of Rhythm Control in Patients With Atrial Fibrillation: JACC State-of-the-Art Review. J Am Coll Cardiol. 2022; 79 (19): 1932–48. DOI: 10.1016/j.jacc.2022.03.337
  5. Wyse D.G., Waldo A.L., DiMarco J.P. et al. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med. 2002; 347 (23): 1825–33. DOI: 10.1056/NEJMoa021328
  6. January C.T., Wann L.S., Calkins H. et al. 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2019; 74 (1): 104–32. DOI: 10.1016/j.jacc.2019.01.011
  7. Corley S.D., Epstein A.E., DiMarco J.P. et al. Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study. Circulation. 2004; 109 (12): 1509–13. DOI: 10.1161/01.CIR.0000121736.16643.11
  8. Saksena S., Slee A., Waldo A.L. et al. Cardiovascular outcomes in the AFFIRM Trial (Atrial Fibrillation Follow-Up Investigation of Rhythm Management). An assessment of individual antiarrhythmic drug therapies compared with rate control with propensity score-matched analyses. J Am Coll Cardiol. 2011; 58 (19): 1975–85. DOI: 10.1016/j.jacc.2011.07.036
  9. Steinberg J.S., Sadaniantz A., Kron J. et al. Analysis of cause-specific mortality in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. Circulation. 2004; 109 (16): 1973–80. DOI: 10.1161/01.CIR.0000118472.77237.FA
  10. Valembois L., Audureau E., Takeda A. et al. Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation. Cochrane Database Syst Rev. 2019; 9 (9): CD005049. DOI: 10.1002/14651858.CD005049.pub5
  11. Ionescu-Ittu R., Abrahamowicz M., Jackevicius C.A. et al. Comparative effectiveness of rhythm control vs rate control drug treatment effect on mortality in patients with atrial fibrillation. Arch Intern Med. 2012; 172 (13): 997–1004. DOI: 10.1001/archinternmed.2012.2266
  12. Andrade J.G., Wells G.A., Deyell M.W. et al. Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation. N Engl J Med. 2021; 384 (4): 305–15. DOI: 10.1056/NEJMoa2029980
  13. Markman T.M., Geng Z., Epstein A.E. et al. Trends in Antiarrhythmic Drug Use Among Patients in the United States Between 2004 and 2016. Circulation. 2020; 141 (11): 937–9. DOI: 10.1161/CIRCULATIONAHA.119.044109
  14. Alrumayh A., Alobaida M. Catheter ablation superiority over the pharmacological treatments in atrial fibrillation: a dedicated review. Ann Med. 2021; 53 (1): 551–7. DOI: 10.1080/07853890.2021.1905873
  15. Hakalahti A., Biancari F., Nielsen J.C. et al. Radiofrequency ablation vs. antiarrhythmic drug therapy as first line treatment of symptomatic atrial fibrillation: systematic review and meta-analysis. Europace. 2015; 17 (3): 370–8. DOI: 10.1093/europace/euu376
  16. Glover B.M., Hong K.L., Dagres N. et al. Impact of body mass index on the outcome of catheter ablation of atrial fibrillation. Heart. 2019; 105 (3): 244–50. DOI: 10.1136/heartjnl-2018-313490
  17. Bazemore T.C., Bolger L.E., Sears S.F. et al. Gender differences in symptoms and functional status in patients with atrial fibrillation undergoing catheter ablation. Pacing Clin Electrophysiol. 2019; 42 (2): 224–9. DOI: 10.1111/pace.13577
  18. Packer D.L., Mark D.B., Robb R.A. et al. Catheter Ablation versus Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) Trial: Study Rationale and Design. Am Heart J. 2018; 199: 192–9. DOI: 10.1016/j.ahj.2018.02.015
  19. Packer D.L., Mark D.B., Robb R.A. et al. Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial. JAMA. 2019; 321 (13): 1261–74. DOI: 10.1001/jama.2019.0693
  20. Perino A.C., Leef G.C., Cluckey A. et al. Secular trends in success rate of catheter ablation for atrial fibrillation: The SMASH-AF cohort. Am Heart J. 2019; 208: 110–9. DOI: 10.1016/j.ahj.2018.10.006
  21. Kirchhof P., Camm A.J., Goette A. et al. Early Rhythm-Control Therapy in Patients with Atrial Fibrillation. N Engl J Med. 2020; 383 (14): 1305–16. DOI: 10.1056/NEJMoa2019422
  22. Metzner A., Suling A., Brandes A. et al. Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST-AFNET 4 trial. Europace. 2022; 24 (4): 552–64. DOI: 10.1093/europace/euab200
  23. Kim D., Yang P.S., You S.C. et al. Age and Outcomes of Early Rhythm Control in Patients With Atrial Fibrillation: Nationwide Cohort Study. JACC Clin Electrophysiol. 2022; 8 (5): 619–32. DOI: 10.1016/j.jacep.2022.02.014
  24. Dickow J., Kirchhof P., Van Houten H.K. et al. Generalizability of the EAST-AFNET 4 Trial: Assessing Outcomes of Early Rhythm-Control Therapy in Patients With Atrial Fibrillation. J Am Heart Assoc. 2022; 11 (11): e024214. DOI: 10.1161/JAHA.121.024214
  25. Lip G.Y.H., Lane D.A., Lenarczyk R. et al. Integrated care for optimizing the management of stroke and associated heart disease: a position paper of the European Society of Cardiology Council on Stroke. Eur Heart J. 2022; 43 (26): 2442–60. DOI: 10.1093/eurheartj/ehac245
  26. Willems S., Borof K., Brandes A. et al. Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial. Eur Heart J. 2022; 43 (12): 1219–30. DOI: 10.1093/eurheartj/ehab593
  27. Wang L., Ze F., Li J. et al. Trends of global burden of atrial fibrillation/flutter from Global Burden of Disease Study 2017. Heart. 2021; 107 (11): 881–7. DOI: 10.1136/heartjnl-2020-317656
  28. Heidenreich P.A., Bozkurt B., Aguilar D. et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022; 79 (17): e263–e421. DOI: 10.1016/j.jacc.2021.12.012
  29. Manolis A.S., Manolis T.A., Manolis A.A. et al. Atrial fibrillation-induced tachycardiomyopathy and heart failure: an underappreciated and elusive condition. Heart Fail Rev. 2022. DOI: 10.1007/s10741-022-10221-1. Online ahead of print.
  30. Mulder B.A., Rienstra M., Van Gelder I.C. et al. Update on management of atrial fibrillation in heart failure: a focus on ablation. Heart. 2022; 108 (6): 422–8. DOI: 10.1136/heartjnl-2020-318081
  31. Roy D., Talajic M., Nattel S. et al. Rhythm control versus rate control for atrial fibrillation and heart failure. N Engl J Med. 2008; 358 (25): 2667–77. DOI: 10.1056/NEJMoa0708789
  32. Di Biase L., Mohanty P., Mohanty S. et al. Ablation Versus Amiodarone for Treatment of Persistent Atrial Fibrillation in Patients With Congestive Heart Failure and an Implanted Device: Results From the AATAC Multicenter Randomized Trial. Circulation. 2016; 133 (17): 1637–44. DOI: 10.1161/CIRCULATIONAHA.115.019406
  33. Marrouche N.F., Brachmann J., Andresen D. et al. Catheter Ablation for Atrial Fibrillation with Heart Failure. N Engl J Med. 2018; 378 (5): 417–27. DOI: 10.1056/NEJMoa1707855
  34. Kuck K.H., Merkely B., Zahn R. et al. Catheter Ablation Versus Best Medical Therapy in Patients With Persistent Atrial Fibrillation and Congestive Heart Failure: The Randomized AMICA Trial. Circ Arrhythm Electrophysiol. 2019; 12 (12): e007731. DOI: 10.1161/CIRCEP.119.007731
  35. Parkash R., Wells G.A., Rouleau J. et al. Randomized Ablation-Based Rhythm-Control Versus Rate-Control Trial in Patients with Heart Failure and Atrial Fibrillation: Results from the RAFT-AF trial. Circulation. 2022. DOI: 10.1161/CIRCULATIONAHA.121.057095. Online ahead of print.
  36. Brachmann J., Sohns C., Andresen D. et al. Atrial Fibrillation Burden and Clinical Outcomes in Heart Failure: The CASTLE-AF Trial. JACC Clin Electrophysiol. 2021; 7 (5): 594–603. DOI: 10.1016/j.jacep.2020.11.021
  37. Noseworthy P.A., Van Houten H.K., Gersh B.J. et al. Generalizability of the CASTLE-AF trial: Catheter ablation for patients with atrial fibrillation and heart failure in routine practice. Heart Rhythm. 2020; 17 (7): 1057–65. DOI: 10.1016/j.hrthm.2020.02.030
  38. Castagno D., Di Donna P., Olivotto I. et al. Transcatheter ablation for atrial fibrillation in patients with hypertrophic cardiomyopathy: Long-term results and clinical outcomes. J Cardiovasc Electrophysiol. 2021; 32 (3): 657–66. DOI: 10.1111/jce.14880
  39. Machino-Ohtsuka T., Seo Y., Ishizu T. et al. Efficacy, safety, and outcomes of catheter ablation of atrial fibrillation in patients with heart failure with preserved ejection fraction. J Am Coll Cardiol. 2013; 62 (20): 1857–65. DOI: 10.1016/j.jacc.2013.07.020
  40. Packer M., Kowey P.R. Building Castles in the Sky: Catheter Ablation in Patients With Atrial Fibrillation and Chronic Heart Failure. Circulation. 2018; 138 (8): 751–3. DOI: 10.1161/CIRCULATIONAHA.118.034583
  41. Reddy Y.N.V., Obokata M., Gersh B.J. et al. High Prevalence of Occult Heart Failure With Preserved Ejection Fraction Among Patients With Atrial Fibrillation and Dyspnea. Circulation. 2018; 137 (5): 534–5. DOI: 10.1161/CIRCULATIONAHA.117.030093
  42. Packer D.L., Piccini J.P., Monahan K.H. et al. Ablation Versus Drug Therapy for Atrial Fibrillation in Heart Failure: Results From the CABANA Trial. Circulation. 2021; 143 (14): 1377–90. DOI: 10.1161/CIRCULATIONAHA.120.050991
  43. Zylla M.M., Leiner J., Ann-Kathrin Rahm A.K. et al. Catheter Ablation of Atrial Fibrillation in Patients With Heart Failure and Preserved Ejection Fraction. Circ Heart Fail. 2022. DOI: 10.1161/CIRCHEARTFAILURE.121.009281. Online ahead of print.
  44. Camm A.J., Blomström-Lundqvist C., Boriani G. et al. AIM-AF: A Physician Survey in the United States and Europe. J Am Heart Assoc. 2022; 11 (6): e023838. DOI: 10.1161/JAHA.121.023838
  45. Dan G.A., Martinez-Rubio A., Agewall S. et al. Antiarrhythmic drugs-clinical use and clinical decision making: a consensus document from the European Heart Rhythm Association (EHRA) and European Society of Cardiology (ESC) Working Group on Cardiovascular Pharmacology, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and International Society of Cardiovascular Pharmacotherapy (ISCP). Europace. 2018; 20 (5): 731–32an. DOI: 10.1093/europace/eux373.
  46. Echt D.S., Liebson P.R., Mitchell L.B. et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med. 1991; 324 (12): 781–8. DOI: 10.1056/NEJM199103213241201
  47. Ruzieh M., Moroi M.K., Aboujamous N.M. et al. Meta-Analysis Comparing the Relative Risk of Adverse Events for Amiodarone Versus Placebo. Am J Cardiol. 2019; 124 (12): 1889–93. DOI: 10.1016/j.amjcard.2019.09.008
  48. Meinertz T., Lip G.Y., Lombardi F. et al. Efficacy and safety of propafenone sustained release in the prophylaxis of symptomatic paroxysmal atrial fibrillation (The European Rythmol/Rytmonorm Atrial Fibrillation Trial [ERAFT] Study). Am J Cardiol. 2002; 90 (12): 1300–6. DOI: 10.1016/s0002-9149(02)02867-9
  49. Pantlin P.G., Bober R.M., Bernard M.L. et al. Class 1C antiarrhythmic drugs in atrial fibrillation and coronary artery disease. J Cardiovasc Electrophysiol. 2020; 31 (3): 607–11. DOI: 10.1111/jce.14335
  50. Ashraf H., Ko N.K., Ladia V. et al. Use of Flecainide in Stable Coronary Artery Disease: An Analysis of Its Safety in Both Nonobstructive and Obstructive Coronary Artery Disease. Am J Cardiovasc Drugs. 2021; 21 (5): 563–72. DOI: 10.1007/s40256-021-00483-9
  51. Rillig A., Magnussen C., Ozga A.K. et al. Early Rhythm Control Therapy in Patients With Atrial Fibrillation and Heart Failure. Circulation. 2021; 144 (11): 845–58. DOI: 10.1161/CIRCULATIONAHA.121.056323
  52. Kipp R., Askari M., Fan J. et al. Real-World Comparison of Classes IC and III Antiarrhythmic Drugs as an Initial Rhythm Control Strategy in Newly Diagnosed Atrial Fibrillation: From the TREAT-AF Study. JACC Clin Electrophysiol. 2019; 5 (2): 231–41. DOI: 10.1016/j.jacep.2018.08.025
  53. Chung R., Houghtaling P.L., Tchou M. et al. Left ventricular hypertrophy and antiarrhythmic drugs in atrial fibrillation: impact on mortality. Pacing Clin Electrophysiol. 2014; 37 (10): 1338–48. DOI: 10.1111/pace.12426
  54. Канорский С.Г. Антиаритмическая терапия у больных с пароксизмальной и персистирующей формами фибрилляции предсердий: определение достижимой цели и оценка имеющихся средств. Кардиология. 2014; 54 (2): 70–4. [Kanorsky S.G. Antiarrhythmic Therapy in Patients With Paroxysmal and Persistent Atrial Fibrillation: Identification of Achievable Goals and Assessment of Available Funds. Kardiologiia. 2014; 54 (2): 70–4 (in Russ.)].
  55. Zhong X., Jiao H., Gao J. et al. Autonomic Tone Variations Prior to Onset of Paroxysmal Atrial Fibrillation. Med Sci Monit. 2022; 28: e934028. DOI: 10.12659/MSM.934028
  56. Арчакова О.А., Багаева Н.С., Комаров Т.Н. и др. Изучение фармакокинетики пролонгированного антиаритмического препарата лаппаконитина гидробромида (Аллафорте®, АО «Фармцентр ВИЛАР», Россия). Разработка и регистрация лекарственных средств. 2022; 11 (1): 140–7. DOI: 10.33380/2305-2066-2022-11-1-140-147. [Archakova O.A., Bagaeva N.S., Komarov T.N. et al. Pharmacokinetics Study of the Long-acting Antiarrhythmic Drug of Lappaconitine Hydrobromide (Allaforte®, JSC «Pharmcenter VILAR», Russia). Razrabotka i registratsiya lekarstvennykh sredstv = Drug development & registration. 2022; 11 (1): 140–7 (in Russ.). DOI: 10.33380/2305-2066-2022-11-1-140-147].
  57. Канорский С.Г. Современная медикаментозная терапия фибрилляции предсердий: выбор тактики, антиаритмических препаратов и схем лечения. Кардиология. 2012; 52 (9): 58–63. [Kanorsky S.G. Modern Drug Therapy of Atrial Fibrillation: Selection of Treatment Strategy, Antiarrhythmic Preparations, and Schemes of Treatment. Kardiologiia. 2012; 52 (9): 58–63 (in Russ.)].
  58. Ayzenberg O., Swissa M., Shlezinger T. et al. Atrial Fibrillation Ablation Success Rate – A Retrospective Multicenter Study. Curr Probl Cardiol. 2022; 101161. DOI: 10.1016/j.cpcardiol.2022.101161. Online ahead of print.
  59. Dunnington G.H., Pierce C.L., Eisenberg S. et al. A heart-team hybrid approach for atrial fibrillation: a single-centre long-term clinical outcome cohort study. Eur J Cardiothorac Surg. 2021; 60 (6): 1343–50. DOI: 10.1093/ejcts/ezab197