Роль мочевой кислоты в развитии сердечно-сосудистых заболеваний: от молекулярных механизмов до клинических проявлений

DOI: https://doi.org/10.29296/25877305-2022-06-01
Номер журнала: 
6
Год издания: 
2022

Н.А. Куницкая, доктор медицинских наук,
А.Л. Арьев, доктор медицинских наук, профессор,
В.С. Немировский, кандидат медицинских наук
Северо-Западный государственный медицинский университет им. И.И. Мечникова Минздрава России, Санкт-Петербург
E-mail: scvssd@yandex.ru

Мочевая кислота (МК) является конечным продуктом метаболизма пуриновых нуклеотидов в организме человека. Распространенность гиперурикемии (ГУ) растет во всем мире. Эпидемиологические исследования показали, что уровни МК положительно коррелируют с сердечно-сосудистыми заболеваниями (ССЗ), включая артериальную гипертензию, атеросклероз, мерцательную аритмию и сердечную недостаточность. ГУ способствует возникновению и развитию ССЗ, регулируя молекулярные сигналы, такие как воспалительная реакция, окислительный стресс, инсулинорезистентность и эндотелиальная дисфункция. Несмотря на многочисленные исследования, молекулярные механизмы развития ГУ до сих пор неясны. Известно, что ингибитор ксантиноксидазы (КСО) – аллопуринол – улучшает сердечно-сосудистые исходы у пациентов с сердечной недостаточностью, ИБС, сахарным диабетом типа 2 и гипертрофией миокарда левого желудочка. Может ли другой ингибитор КСО – фебуксостат – положительно влиять на сердечно-сосудистую систему? Кроме того, неясно может ли лечение, снижающее содержание МК, принести пользу пациентам с бессимптомной ГУ. В данном обзоре представлены современные данные о клеточных и молекулярных взаимосвязях ССЗ, связанных с ГУ, а также клинические данные об эффективности уратснижающей терапии у пациентов с ССЗ.

Ключевые слова: 
кардиология
терапия
мочевая кислота
сердечно-сосудистые заболевания
молекулярный механизм
клиническая перспектива.

Для цитирования
Куницкая Н.А., Арьев А.Л., Немировский В.С. . Роль мочевой кислоты в развитии сердечно-сосудистых заболеваний: от молекулярных механизмов до клинических проявлений . Врач, 2022; (6): 5-12 https://doi.org/10.29296/25877305-2022-06-01


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