Профилактика ожирения и склерополикистоза с применением биологически активной добавки SELENBIO for women

DOI: https://doi.org/10.29296/25877305-2022-03-07
Номер журнала: 
3
Год издания: 
2022

Т.В. Потупчик(1), кандидат медицинских наук, Е.В. Окладникова(1), кандидат медицинских наук,
Т.В. Дресвянская(2) (1)Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого
Минздрава России (2)Красноярская межрайонная клиническая больница №4 E-mail: potupchik_tatyana@mail.ru

В статье представлен обзор сведений о роли микроэлемента селена (Se) в липидном и углеводном обмене. Приведены данные клинических исследований Se, показавшие значение дефицита данного микроэлемента в патогенезе развития ожирения и склерополикистоза яичников. Показано, что в качестве профилактики ожирения и склерополикистоза яичников возможно применение биологически активной добавки SELENBIO for women, полученной методом биофортификации астрагала шерстистоцветкового L-селеноцистином, благодаря чему препарат обладает высокой биодоступностью и низким риском развития токсических эффектов.
Ключевые слова: 
ожирение
углеводный обмен
липидный обмен
склерополикистоз
селен
SELENBIO for women
Для цитирования
Т.В. Потупчик, Е.В. Окладникова, Т.В. Дресвянская Профилактика ожирения и склерополикистоза с применением биологически активной добавки SELENBIO for women . Врач, 2022; (3): 35-42 https://doi.org/10.29296/25877305-2022-03-07

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  74. Razavi M., Jamilian M., Kashan Z.F. et al. Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome. Horm Metab Res. 2016; 48 (3): 185–90. DOI: 10.1055/s-0035-1559604
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  79. Soares de Oliveira A.R., Jayanne Climaco Cruz K., Beatriz Silva Morais J. et al. Selenium status and oxidative stress in obese: Influence of adiposity. Eur J Clin Invest. 2021; 51 (9): e13538. DOI: 10.1111/eci.13538 Steinbrenner H. Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism. Free Radic Biol Med. 2013; 65: 1538–47. DOI: 10.1016/j.freeradbiomed.2013.07.016
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  81. Suganami T., Ogawa Y. Adipose tissue macrophages: their role in adipose tissue remodeling. J Leukoc Biol. 2010; 88 (1): 33–9. DOI: 10.1189/jlb.0210072
  82. Szczuko M., Zapalowska-Chwyć M., Drozd R. A Low Glycemic Index Decreases Inflammation by Increasing the Concentration of Uric Acid and the Activity of Glutathione Peroxidase (GPx3) in Patients with Polycystic Ovary Syndrome (PCOS). Molecules. 2019; 24 (8): 1508. DOI: 10.3390/molecules24081508
  83. Torres D.J., Pitts M.W., Hashimoto A.C. et al. Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance. Nutrients. 2019; 11: 1693. DOI: 10.3390/nu11071693
  84. Touat-Hamici Z., Legrain Y., Bulteau A.L. et al. Selective up-regulation of human selenoproteins in response to oxidative stress. J Biol Chem. 2014; 289 (21): 14750–61. DOI: 10.1074/jbc.M114.551994
  85. Tun S., Spainhower C.J., Cottrill C.L. et al. Therapeutic Efficacy of Antioxidants in Ameliorating Obesity Phenotype and Associated Comorbidities. Front Pharmacol. 2020; 13 (11): 1234. DOI: 10.3389/fphar.2020.01234
  86. Vinceti M., Filippini T., Rothman K.J. Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis. Eur J Epidemiol. 2018; 33 (9): 789–810. DOI: 10.1007/s10654-018-0422-8
  87. Wang Y., Gao X., Pedram P. et al. Significant Beneficial Association of High Dietary Selenium Intake with Reduced Body Fat in the CODING Study. Nutrients. 2016; 8 (1): 24. DOI: 10.3390/nu8010024
  88. Zagrodzki P., Krzyczkowska-Sendrakowska M., Nicol F. et al. Selenium status parameters in patients with polycystic ovary syndrome. J Trace Elem Med Biol. 2017; 44: 241–6. DOI: 10.1016/j.jtemb.2017.08.012
  89. Zhang Q., Qian Z.Y., Zhou P.H. et al. Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet. Lipids Health Dis. 2018; 17 (1): 165. DOI: 10.1186/s12944-018-0815-4
  90. Zhao H., Li K., Tang J.Y. et al. Expression of Selenoprotein Genes Is Affected by Obesity of Pigs Fed a High-Fat Diet. J Nutr. 2015; 145 (7): 1394–401. DOI: 10.3945/jn.115.211318
  91. Zhong Q., Lin R., Nong Q. Adiposity and Serum Selenium in U.S. Adults. Nutrients. 2018; 10 (6): 727. DOI: 10.3390/nu10060727