Неалкогольная жировая болезнь печени – факторы ее риска и она как фактор риска

DOI: https://doi.org/10.29296/25877305-2019-12-22
Скачать статью в PDF
Номер журнала: 
12
Год издания: 
2019

Ю. Евсютина, кандидат медицинских наук Национальный медицинский исследовательский центр профилактической медицины Минздрава России, Москва E-mail: evsyutina.yulia@gmail.com

Мировая распространенность неалкогольной жировой болезни печени (НАЖБП) составляет 25%, в Российской Федерации этот показатель значительно выше. НАЖБП тесно связана с ожирением, сахарным диабетом типа 2, метаболическим синдромом, сердечно-сосудистыми заболеваниями. У пациентов с НАЖБП значительно повышен риск развития цирроза, терминальной печеночной недостаточности, требующей трансплантации печени, и гепатоцеллюлярной карциномы, а также смертности (общей, кардиоваскулярной и гепатологической). Профилактика и лечение НАЖБП направлены на коррекцию модифицируемых факторов риска, в первую очередь, на снижение массы тела (на 7–10% от изначального показателя) за счет ежедневной физической активности умеренной интенсивности и гипокалорийной диетой.

Ключевые слова: 
гастроэнтерология
неалкогольная жировая болезнь печени
неалкогольный стеатогепатит
гепатоцеллюлярная карцинома
диета
физическая активность

Для цитирования
Евсютина Ю. Неалкогольная жировая болезнь печени – факторы ее риска и она как фактор риска . Врач, 2019; (12): 85-88 https://doi.org/10.29296/25877305-2019-12-22


It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

Список литературы: 
  1. Younossi Z., Koenig A., Abdelatif D. et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes // Hepatology. – 2016; 64: 73–84. DOI: 10.1002/hep.28431.
  2. Chalasani N., Younossi Z., Lavine J. et al. The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases // Hepatology. – 2018; 67: 328–57. DOI: 10.1002/hep.29367.
  3. Sung K., Kim B., Cho Y. et al. Predicting incident fatty liver using simple cardio-metabolic risk factors at baseline // BMC Gastroenterology. – 2012; 12: 84. DOI: 10.1186/1471-230X-12-84.
  4. Xu C., Yu C., Ma H. et al. Prevalence and risk factors for the development of nonalcoholic fatty liver disease in a nonobese Chinese population: the Zhejiang Zhenhai Study // Am. J. Gastroenterol. – 2013; 108 (8): 1299–304. DOI: 10.1038/ajg.2013.104.
  5. Lee K. Metabolic syndrome predicts the incidence of hepatic steatosis in Koreans // Obes. Res. Clin. Pract. – 2010; 4 (3): e217–e224. DOI: 10.1016/j.orcp.2010.02.004.
  6. Hamabe A., Uto H., Imamura Y. et al. Impact of cigarette smoking on onset of nonalcoholic fatty liver disease over a 10-year period // J. Gastroenterol. – 2011; 46 (6): 769–78. Doi: 10.1007/s00535-011-0376-z.
  7. Kim N., Kim J., Kim Y. et al. Clinical and metabolic factors associated with development and regression of nonalcoholic fatty liver disease in nonobese subjects // Liver Int. – 2014; 34 (4): 604–11. DOI: 10.1111/liv.12454.
  8. Koehler E., Schouten J., Hansen B. et al. Prevalence and risk factors of non-alcoholic fatty liver disease in the elderly: results from the Rotterdam study // J. Hepatol. – 2012; 57: 1305–11. DOI: 10.1016/j.jhep.2012.07.028.
  9. Frith J., Day C., Henderson E. et al. Non-alcoholic fatty liver disease in older people // Gerontology. – 2009; 55: 607–13. DOI: 10.1159/000235677.
  10. Masuoka H., Chalasani N. Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals // Ann. NY Acad. Sci. – 2013; 1281: 106–22. DOI: 10.1111/nyas.12016.
  11. Dongiovanni P., Anstee Q., Valenti L. Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment // Curr. Pharm. Des. – 2013; 19: 5219–38. DOI: 10.2174/13816128113199990381.
  12. Sasaki A., Nitta H., Otsuka K. et al. Bariatric surgery and non-alcoholic Fatty liver disease: current and potential future treatments // Front Endocrinol. – 2014; 5: 164. DOI: 10.3389/fendo.2014.00164.
  13. Subichin M., Clanton J., Makuszewski M. et al. Liver disease in the morbidly obese: a review of 1000 consecutive patients undergoing weight loss surgery // Surg. Obes. Relat. Dis. – 2015; 11: 137–41. DOI: 10.1016/j.soard.2014.06.015.
  14. Byrne C., Targher G. NAFLD: a multisystem disease // J. Hepatol. – 2015; 62: S47–64. DOI: 10.1016/j.jhep.2014.12.012.
  15. Prashanth M., Ganesh H., Vima M. et al. Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus // J. Assoc. Physicians India. – 2009; 57: 205–10. DOI: 10.1155/2016/3805372.
  16. Fan N., Zhang L., Xia Z. et al.Sex-specific association between serum uric acid and nonalcoholic fatty liver disease in type 2 diabetic patients // J. Diabetes Res. – 2016; 2016: 3805372. DOI: 10.1155/2016/3805372.
  17. Younossi Z., Anstee Q., Marietti M. et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention // Nat. Rev. Gastroenterol. Hepatol. – 2018; 15 (1): 11–20. DOI: 10.1038/nrgastro.2017.109.
  18. George E., Forsyth A., Itsiopoulos C. et al. Practical Dietary Recommendations for the Prevention and Management of Nonalcoholic Fatty Liver Disease in Adults // Adv. Nutr. – 2018; 9 (1): 30–40. DOI: 10.1093/advances/nmx007.
  19. Ma J., Hennein R., Liu C. et al. Improved Diet Quality Associates With Reduction in Liver Fat, Particularly in Individuals With High Genetic Risk Scores for Nonalcoholic Fatty Liver Disease // Gastroenterology. – 2018; 155: 107–17. DOI:10.1053/j.gastro.2018.03.038.
  20. St George A., Bauman A., Johnston A. et al. Independent effects of physical activity in patients with nonalcoholic fatty liver disease // Hepatology. – 2009; 50: 68–76. DOI: 10.1002/hep.22940.
  21. Sung K.-C., Ryu S. Lee J.-Y. et al. Effect of exercise on the development of new fatty liver and the resolution of existing fatty liver // J. Hepatol. – 2016; 65: 791–7. DOI: 10.1016/j.jhep.2016.05.026.
  22. Orci L., Gariani K., Oldani G. et al. Exercise-based Interventions for Nonalcoholic Fatty Liver Disease: A Meta-analysis and Meta-regression // Clin. Gastroenterol. Hepatol. – 2016; 14 (10): 1398–411. DOI: 10.1016/j.cgh.2016.04.036.
  23. Korean Association for the Study of the Liver (KASL) KASL clinical practice guidelines: management of nonalcoholic fatty liver disease // Clin. Mol. Hepatol. – 2013; 19: 325–48. DOI: 10.3350/cmh.2013.19.4.325.
  24. Abdelmalek M., Suzuki A., Guy C. et al. Nonalcoholic Steatohepatitis Clinical Research Network. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease // Hepatology. – 2010; 51 (6): 1961–71. DOI: 10.1002/hep.23535.
  25. Lieber C., Weiss D., Groszmann R. et al. II. Veterans Affairs Cooperative Study of polyenylphosphatidylcholine in alcoholic liver disease // Alcohol Clin. Exp. Res. – 2003; 27 (11): 1765–72. DOI: 10.1097/01.ALC.0000093743.03049.80.
  26. Younossi Z., Otgonsuren M., Henry L. et al. Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009 // Hepatology. – 2015; 62: 1723–30. DOI: 10.1002/hep.28123.
  27. Kanwal F., Kramer J., Mapakshi S. et al. Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty Liver Disease // Gastroenterology. – 2018; 155 (6): 1828–37.e2. DOI: 10.1053/j.gastro.2018.08.024.
  28. Younossi Z. Non-alcoholic fatty liver disease – A global public health perspective // J. Hepatol. – 2019; 70 (3): 531–44. DOI: 10.1016/j.jhep.2018.10.033.
  29. Wong R., Aguilar M., Cheung R. et al. Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States // Gastroenterology. – 2015; 148 (3): 547–55. DOI: 10.1053/j.gastro.2014.11.039.
  30. Angulo P., Kleiner D., Dam-Larsen S. et al. Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease // Gastroenterology. – 2015; 149: 389––97.e10. DOI: 10.1053/j.gastro.2015.04.043.