Генетические аспекты анкилозирующего спондилита

DOI: https://doi.org/10.29296/25877305-2019-12-19
Номер журнала: 
12
Год издания: 
2019

В. Мордовский(1, 2), Е. Капустина(1, 2), кандидат медицинских наук, А. Чернова(1, 2), доктор медицинских наук, С. Никулина(1), доктор медицинских наук, Н. Аксютина(1), доктор медицинских наук, Т. Потупчик(1), кандидат медицинских наук 1-Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого 2-Российско-итальянская лаборатория медицинской генетики MAGI Russia, Красноярск E-mail: v.mordovskii@krasgmu.ru

Представлен обзор по генетическим аспектам анкилозирующего спондилита (АС) – хронического воспалительного заболевания аутоиммуного происхождения с преимущественным поражением аксиального скелета. С начала эпохи полногеномного поиска ассоциаций (GWAS) выявлено более 150 локусов, ассоциированных с АС, но это позволяет объяснить не более 30% случаев наследования. В обзоре предпринята попытка понять роль представленных генов в развитии АС. Продолжение исследований в указанном направлении позволит создать предпосылки к появлению новых целей для таргетной терапии.
Ключевые слова: 
анкилозирующий спондилит, HLA-B27, фактор некроза опуходи, ERAP1, одиночный нуклеотидный полиморфизм, генетика

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