ПАТОГЕНЕЗ ЛИХОРАДКИ И ПАТОГЕНЕТИЧЕСКИ ОБОСНОВАННЫЙ ВЫБОР АНТИПИРЕТИЧЕСКИХ СРЕДСТВ

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Номер журнала: 
12
Год издания: 
2016

В. Делягин, доктор медицинских наук, профессор Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева, Москва E-mail: delyagin-doktor@yandex.ru

Лихорадка возникает под действием экзогенных и эндогенных пирогенов и может вызвать глубокие (иногда необратимые) изменения во многих органах и системах, что свидетельствует о необходимости активного снижения гипертермии.

Ключевые слова: 
педиатрия
лихорадка
патогенез
воспаление
лечение
Нурофен

Для цитирования
Делягин В. ПАТОГЕНЕЗ ЛИХОРАДКИ И ПАТОГЕНЕТИЧЕСКИ ОБОСНОВАННЫЙ ВЫБОР АНТИПИРЕТИЧЕСКИХ СРЕДСТВ . Врач, 2016; (12): 67-71


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Список литературы: 
  1. Sajadi M., Mackowiak Ph. Temperature Regulation and the Pathogenesis of Fever. In: Bennet J., Dolin R., Blaser B. (Ed.) Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 8th Ed. / Saunders, 2015; 708–20e4.
  2. Majno G. The Healing Hand: Man and Wound in the Ancient World Cambridge: Harvard University Press, 1991; 571 p.
  3. Siegel R. (Ed.) Galen’s System of Physiology and Medicine / New York: Karger; 1968; 420 p.
  4. Sajadi M., Bonabi R., Sajadi M. et al. Akhawayni and the first fever curve // Clin. Infect. Dis. – 2012; 55 (7): 976–80.
  5. Mackowiak P., Worden G. Carl Reinhold August Wunderlich and the evolution of clinical thermometry // Clin. Infect. Dis. – 1994; 18 (3): 458–67.
  6. Commission for Thermal Physiology of the International Union of Physiological Sciences. Glossary of terms for thermal physiology (3rd Ed.) // Jpn. J. Physiol. – 2001; 51 (2): 245–80.
  7. Делягин В.М. Лихорадка. Многообразие причин и сложность решения // Consilium Medicum. Педиатрия. – 2011; 4: 49–52.
  8. Делягин В.М., Мальцев В.И., Румянцев А.Г. Лекции по клинической диагностике внутренних болезней / Киев: Морион, 2007; 664 с.
  9. Nakamura K., Morrison S. A thermosensory pathway mediating heat-defense responses // Proc. Natl. Acad. Sci. USA. – 2010; 107 (19): 8848–53.
  10. Tan C., Cooke E., Leib D. et al. Warm-sensitive neurons that control body temperature // Cell. – 2016; 167 (1): 47–59.
  11. McAllen R., Tanaka M., Ootsuka Y. et al. Multiple thermoregulatory effectors with independent central controls // Eur. J. Appl. Physiol. – 2010; 109 (1): 27–33.
  12. Walter E., Sameer H.-J., Caratallo M. et al. The pathophysiological basis of fever // Crit. Care. – 2016, 20: 200. Published online 2016 Jul 14. doi:10.1186/s13054-016-1375-5.
  13. Dinarello C. Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed // J. Endotoxin. Res. – 2004; 10 (4): 201–22.
  14. Kroufol Z. Cytokines and mental health / Springer, 2003; 428 p.
  15. Chase K., Cone L., Rosen C. et al. The value of interleukin 6 as a peripheral diagnostic marker in schizophrenia // BMC Psychiatry. – 2016; doi: 10.1186/s12888-016-0866-x.
  16. Vlad M., Ionescu N., Ispas A. et al. Morphological changes during acute experimental short-term hyperthermia // Rom. J. Morphol. Embryol. – 2010; 51 (4): 739–44.
  17. Argaud L., Ferry T., Le Q. et al. Short- and long-term outcomes of heatstroke following the 2003 heat wave in Lyon // France Arch. Intern. Med. – 2007; 167 (20): 2177–83.
  18. Etulain J., Lapponi M., Patrucchi S. et al. Hyperthermia inhibits platelet hemostatic functions and selectively regulates the release of alpha-granule proteins // J. Thromb. Haemost. – 2011; 9 (8): 1562–71.
  19. Pease S., Bouadma L., Kermarrec N. et al. Early organ dysfunction course, cooling time and outcome in classic heatstroke // Intens Care Med. – 2009; 35 (8): 1454–8.
  20. Badoer E. Role of the hypothalamic PVN in the regulation of renal sympathetic nerve activity and blood flow during hyperthermia and in heart failure // Am. J. Physiol. Renal. Physiol. – 2010; 298 (4): F839–46.
  21. Hall D., Buettner G., Oberley L. et al. Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia // Am. J. Physiol. Heart Circ. Physiol. – 2001; 280: H509–21.
  22. Carleton B., Smith M., Gelin M. et al. Paediatric adverse drug reaction reporting: understanding and future directions // Can. J. Clin. Pharmacol. – 2007; 14 (1): 45–57.
  23. Yewale V., Dharmapalan D. Promoting appropriate use of drugs in children // Int. J. Pediatr. – 2012; 2012: 906570.
  24. Ушкалова Е.А. Выбор оптимального жаропонижающего средства в педиатрической практике // Лечащий врач. – 2012; 8: 66–9.
  25. Hay A., Costelloe C., Redmond N. et al. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): Randomised controlled trial // BMJ. – 2008; 337 (a1302): 1–9.
  26. Pelen F., Verriere F. Treatment of Fever: Monotherapy with Ibuprofen. Ibuprofen Paediatric Suspension Containing 100 mg per 5 ml. Multi Centre Acceptability Study Conducted in Hospital // Annales de Pediatrie. – 1998; 45 (10): 719–28.
  27. Yue Z., Jiang P., Sun H. и др. Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system // Eur. J. Clin. Pharmacol. – 2014; 70 (4): 479–82. doi: 10.1007/s00228-014-1643-8. Epub 2014 Jan 21.
  28. Vecchio M., Sundel E. Alternating Antipyretics: Is This an Alternative? // Pediatrics. – 2001; 108 (5): 1236–7.
  29. Lesko S., Mitchell A. An assessment of the safety of pediatric ibuprofen: a practitioner-based randomized clinical trial // JAMA. – 1995; 273 (12): 929–33.
  30. Баранов А.А., Таточенко В.К., Бакрадзе М.Д. Лихорадящий ребенок. Протоколы диагностики и лечения (сер. «Клинические рекомендации для педиатров»). Изд. 2-е испр. и дополн. / www.d22d.ru/load/42-1-0-1103 и www.d22d.ru/load/42-1-0-1104.
  31. Lieberthal A., Carroll A., Chonmaitree T. et al. Clinical Practice Guideline: The Diagnosis and Management of Acute Otitis Media // Pediatrics. – 2013; 131 (3): e964–e99.
  32. Vecchio M., Sundel E. Alternating Antipyretics: Is This an Alternative? // Pediatrics. – 2001; 108 (5): 1236–7.
  33. Chiappini E., Principi N., Longhi R. et al. Management of fever in children: summary of the Italian Pediatric Society guidelines // Clin. Ther. – 2009; 31 (8): 1826–43.
  34. Autret-Leca E. A general overview of the use of ibuprofen in paediatrics // Int. J. Clin. Pract. Suppl. – 2003; 135: 9–12.
  35. Pursell E. Treating fever in children: paracetamol or ibuprofen? // Br. J. Community Nurs. – 2002; 7 (6): 316–20.
  36. Pereira G., Dagostini J., Pizzol T. Alternating antipyretics in the treatment of fever in children: a systematic review of randomized clinical trials // J. Pediatr. (Rio J.). – 2012; 88 (4): 289–96.
  37. Mayoral C., Marino R., Rosenfeld W., Greensher J. Alternating antipyretics: is the alternative // Pediatrics. – 2000; 105 (5): 1009–12.
  38. Wong T., Stang A., Ganshorn H. et al. Cochrane in context: combined and alternating paracetamol and ibuprofen therapy for febrile children // Evid. Based Child Health. – 2014; 9 (3): 730–2.
  39. National Institute for Health and Care Excellence (NICE). CG160 Feverish illness in children. May 2013. Accessed 4th November 2013. Available at: http://guidance.nice.org.uk/CG160.