HAC (Russian)
RSCI (Russian)
Ulrichsweb (Ulrich’s Periodicals Directory)
Scientific Indexing Services

Application of hawthorn blood-red and rosehip fruits in the drug Kardioton in the prevention of various diseases

DOI: https://doi.org/10.29296/25877305-2022-12-17

Professor D. Dedov, MD
Tver State Medical University
Tver Regional Clinical Cardiology Dispensary

Purpose of the study. To study the possibility of using hawthorn blood-red and rosehip fruits in the drug Kardioton company "Parafarm" in the prevention of various diseases. Material and methods. The analysis of 27 Russian and foreign publications reflecting the use of hawthorn blood-red and rosehip fruits in the drug Kardioton in the prevention of various diseases. Results and discussion. Noted their cardiotonic, coronary dilation, hypotensive, antiarrhythmic, antispasmodic effect of hawthorn preparations. Reflected the growing interest in hawthorn and the prospect of its use to treat a number of diseases: intoxication, inflammation, arthritis, diabetes, hyperlipidemia, obesity, cancer. All biologically active substances of hawthorn and rosehip are preserved in the drug Kardioton ("Parapharm") in full through the use of whole plant parts, not extracts from them, and the use of unique technology for Russia cryoprocessing plant raw materials. Conclusion. Drug Kardioton, produced by "Parapharm" on unique Russian technology for cryoprocessing from medicinal plants grown on their own fields in environmentally clean regions of Russia, has antioxidant, cardioprotective, hypotensive, hypocholesterolemic, anti-inflammatory, metabolic effect and can be used in the complex prevention of various diseases in addition to the main etiotropic, pathogenetic and symptomatic therapy, taking into account the individual approach.

hawthorn blood-red
rosehip fruits
Kardioton drug
Parapharm company
disease prevention.

  1. Khishova O.M., Kravchenko E.V., Rodionova T.W. Pharmacological action of hawthorn blood-red and its use in medicine. Vestnik farmatsii. 2004; 2 (24): 69–76 (in Russ.).
  2. Samylina I.A., Sorokina A.A., Pyatigorskaya N.V. Hawthorn (Crataegus): options for medical use. Farmateka. 2010; 8(202): 83–5 (in Russ.).
  3. Zhdanov D.A., Kurkin V.A., Braslavsky V.B. et al. Actual Aspects of Quality Control and Standardization of Rosehip Fruits. Drug development & registration. 2021; 10 (3): 167–75 (in Russ.). DOI: 10.33380/2305-2066-2021-10-3-167-175
  4. Kurkin V.A., Sharova O.V., Afanasyeva P.V. Improvement of techniques for the quantitative determination of the amount of carotenoids in the raw material «Rosehip fruits». Chemistry of vegetable raw materials. 2020; 3: 131–8 (in Russ.). DOI: 10.14258/jcprm.2020036093
  5. Karomatov I.Dz., Davlatova M.S. Amonov M.K. et al. The prospects of application in cardiological and all-medical practice of the simple the hawthorn (the review of literature). Biology and integrative medicine. 2017; 1: 251–76 (in Russ.).
  6. Shameh S., Alirezalu A., Hosseini B. et al. Fruit phytochemical composition and color parameters of 21 accessions of five Rosa species grown in North West Iran. J Sci Food Agric. 2019; 99 (13): 5740–51. DOI: 10.1002/jsfa.9842
  7. Mármol I., Sánchez-de-Diego C., Jiménez-Moreno N. et al. Therapeutic Applications of Rose Hips from Different Rosa Species. Int J Mol Sci. 2017; 18 (6): 1137. DOI: 10.3390/ijms18061137
  8. Ayati Z., Amiri M.S., Ramezani M. et al. Phytochemistry, Traditional Uses and Pharmacological Profile of Rose Hip: A Review. Curr Pharm Des. 2018; 24 (35): 4101–24. DOI: 10.2174/1381612824666181010151849
  9. Gruenwald J., Uebelhack R., Moré M.I. Rosa canina – Rose hip pharmacological ingredients and molecular mechanics counteracting osteoarthritis – A systematic review. Phytomedicine. 2019; 60: 152958. DOI: 10.1016/j.phymed.2019.152958
  10. Aleksashina S.A., Makarova N.V., Demenina L.G. Antioxidant potential of wild rose. Problems of Nutrition. 2019; 88 (3): 84–9 (in Russ.). DOI: 10.24411/0042-8833-2019-10033
  11. Roman I., Stănilă A., Stănilă S. Bioactive compounds and antioxidant activity of Rosa canina L. biotypes from spontaneous flora of Transylvania. Chem Cent J. 2013; 7 (1): 73. DOI: 10.1186/1752-153X-7-73
  12. Nađpal J.D., Lesjak M.M., Mrkonjić Z.O. et al. Phytochemical composition and in vitro functional properties of three wild rose hips and their traditional preserves. Food Chem. 2018; 241: 290–300. DOI: 10.1016/j.foodchem.2017.08.111
  13. Fascella G., D'Angiolillo F., Mammano M.M. et al. Bioactive compounds and antioxidant activity of four rose hip species from spontaneous Sicilian flora. Food Chem. 2019; 289: 56–64. DOI: 10.1016/j.foodchem.2019.02.127
  14. Marzec-Wróblewska U., Wesolowski M., Waleron K. et al. Phenolic Composition and Biological Properties of Wild and Commercial Dog Rose Fruits and Leaves. Molecules. 2020; 25 (22): 5272. DOI: 10.3390/molecules25225272
  15. Dedov D. The drug Cardioton: composition, pharmacological properties, the possibilities of preventing cardiovascular diseases. Vrach. 2022; 33 (9): 36–8 (in Russ.). DOI: 10.29296/25877305-2022-09-06
  16. Karomatov I.D., Zhalilov N.A. Chemical composition and medicinal properties of hawthorn. Biology and Integrative Medicine. 2019; 1 (29): 109–41.
  17. Korsun V.F., Korsun E V., Korshikova Yu.I. et al. Phytotherapy for heart diseases. Herbs of life. M.: Tsentrpoligraf, 2020; 383 p. (in Russ.).
  18. Sokolov S. Ya., Zamotaev I.P. Handbook of medicinal plants (Phytotherapy). 2nd ed., stereotyped. M.: Meditsina, 1988; 464 p. (in Russ.).
  19. Barnaulov O.D. Phytotherapy of patients with cardiovascular diseases. 2nd ed. correct and additional. St. Petersburg: Eco-Vector, 2018; 271 p. (in Russ.).
  20. Basantsova N.Yu., Tibekina L.M., Shishkin A.N. A role of the autonomic nervous system in cerebro-cardiac disorders. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2017; 117 (11): 153–60 (in Russ.). DOI: 10.17116/jnevro2017117111153-160
  21. Lurie T.V., Fedulov A.S. Blood supply to the brain and spinal cord. Syndromology of circulatory disorders in various vascular pools: teaching material. Minsk: BSMU, 2015; 63 p. (in Russ.).
  22. Mikhno L., Levshin I., Polikarpochkin A. et al. Use of pharmacological agents to preserve, restore, and improve the performance of young hockey players. Vrach. 2018; 29 (9): 67–71 (in Russ.). DOI: 10.29296/25877305-2018-09-16
  23. Vinogradova O.P., Rakhmatullov F.K., Ostanin M.A. Izuchenie techeniya ekstrasistolicheskikh aritmii bez strukturnykh izmenenii u beremennykh zhenshchin. V sb.: Aktual'nye voprosy diagnostiki, lecheniya i reabilitatsii bol'nykh. Mat-ly XXI Mezhregion. nauchno-prakt. konf. 2021; р. 50–3 (in Russ.).
  24. Dorogova I.V., Usanov V.D., Bartos L.F. et al. Features of parameters of peripheral, central blood pressure and indicators of vessels rigidity in pregnant women with hypertensive disorders. Regional blood circulation and microcirculation. 2016; 15 (2): 51–9 (in Russ.). DOI: 10.24884/1682-6655-2016-15-2-51-59
  25. Petrova E., Herzog N., Baranova G. et al. Mutually reinforcing triad: depression, erectile dysfunction and cardiovascular pathology in men. Vrach. 2019; 30 (12): 3–6 (in Russ.). DOI: 10.29296/25877305-2019-12-01
  26. Kondrachenko M.Yu. Diastolic cardiac function in patients with type 1 diabetes mellitus. Kazan medical journal. 2006; 87 (3): 174–9 (in Russ.).
  27. Elistratov D.G., Trifonov V.N. Biologicheski aktivnaya dobavka k pishche dlya profilaktiki zabolevanii i ozdorovleniya serdechno-sosudistoi sistemy. Patent na izobretenie RU 2415611 C1, 10.04.2011. Zayavka №2009144334/13 ot 30.11.2009 (in Russ.).