Integrative medicine and aging prevention: state-of-the-art

DOI: https://doi.org/10.29296/25877305-2022-12-01
Issue: 
12
Year: 
2022

Ya. Ashikhmin(1, 2), Candidate of Medical Sciences, A. Ratnikova(1, 3), Candidate
of Medical Sciences; O. Felsendorff(1, 4), Candidate of Psychological Sciences;
A. Melnikov(5); O. Dikur(6) Candidate of Medical Sciences; M. Grudina1
1-“Pervaya Liniya” (First Line) Health Care Resort, Saint Petersburg
2-Center for Healthcare Quality Assessment and Control of the Ministry of Health of the Russia, Moscow
3-L.G. Sokolov North-Western District Research and Clinical Center, Federal Biomedical Agency of Russia, Saint Petersburg
4-Saint Petersburg State University
5-Guta Clinic, Moscow
6-I.M. Sechenov First Moscow State Medical University (Sechenov University),

Health care focuses primarily on the treatment and prevention of specific diseases, while there are very few high-quality studies of the prevention of aging and the maintenance of high quality of life (or improvement) in healthy people. This review considers the most effective and evidence-based integrative medicine methods used in apparently healthy people for their health improvement.
Keywords: 
well-being
integrative medicine
aging prevention
preventive medicine

References: 
  1. Jameson J., Fauci A., Kasper D. et al. Harrison's Principles of Internal Medicine. 20th ed. New York: McGraw-Hill Education, 2018; 214 р.
  2. Pignolo R. Exceptional Human Longevity. Mayo Clin Proc. 2019; 94 (1): 110–24. DOI: 10.1016/j.mayocp.2018.10.005
  3. Levine M., Lu A., Quach A. et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018; 10 (4): 573–91. DOI: 10.18632/aging.101414
  4. Hjelmborg J., Iachine I., Skytthe A. et al. Genetic influence on human lifespan and longevity. Hum Genet. 2006; 119 (3): 312–21. DOI: 10.1007/s00439-006-0144-y
  5. Mkrtchyan G., Abdelmohsen R., Andreux P. et al. ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY). 2020; 12 (24): 24484–503. DOI: 10.18632/aging.202454
  6. Demidenko O., Barardo D., Budovskii V. et al. Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (Albany NY). 2021; 13 (22): 24485–99. DOI: 10.18632/aging.203736
  7. Fletcher G.F., Ades P.A., Kligfield P. et al. Exercise standards for testing and training: a scientific statement from the American Heart Association. Circulation. 2013; 128 (8): 873–934. DOI: 10.1161/CIR.0b013e31829b5b44
  8. Jia G., Aroor A.R., Jia C. et al. Endothelial cell senescence in aging-related vascular dysfunction. Biochim Biophys Acta Mol Basis Dis. 2019; 1865 (7): 1802–9. DOI: 10.1016/j.bbadis.2018.08.008
  9. Flores-Ramirez A.G., Tovar-Villegas V.I., Maharaj A. et al. Effects of L-Citrulline Supplementation and Aerobic Training on Vascular Function in Individuals with Obesity across the Lifespan. Nutrients. 2021; 13 (9): 2991. DOI: 10.3390/nu13092991
  10. Visseren F., Mach F., Smulders Y. et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021; 42 (34): 3227–337. DOI: 10.1093/eurheartj/ehab484
  11. Colman R., Anderson R., Johnson S. et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009; 325 (5937): 201–4. DOI: 10.1126/science.1173635
  12. Attina A., Leggeri C., Paroni R. et al. Fasting: How to Guide. Nutrients. 2021; 13 (5): 1570. DOI: 10.3390/nu13051570
  13. De Cabo R., Mattson M. Effects of Intermittent Fasting on Health, Aging, and Disease. N Engl J Med. 2019; 381: 2541–51. DOI: 10.1056/NEJMra1905136
  14. Alimujiang A., Wiensch A., Boss J. Association Between Life Purpose and Mortality Among US Adults Older Than 50 Years. JAMA Netw Open. 2019; 2 (5): e194270. DOI: 10.1001/jamanetworkopen.2019.4270
  15. Купцова Е.А. Психическая регуляция как компонент культуры здоровья. Вестник Челябинского государственного педагогического университета. 2018; 2: 223 [Kuptsova E.A. Psychic self-regulation as one of health culture components. The Herald of South-Ural state Humanities-Pedagogical University. 2018; 2: 223 (in Russ.)]. DOI:10.25588/CSPU.2018.02.23
  16. Brucks H.M., Steffflre B. Theories of Counseling. 3rd ed. New York: McGraw-Hill, 1979; р. 352.
  17. Cандомирский М.Е. Психосоматика и телесная терапия: Практическое руководство. М.: Независимая фирма «Класс», 2007; 592 с. [Sandomiersky M.E. Psychosomatics and Body Therapy: A Practical Guide. M.: Class, 2007; 592 p. (in Russ.)].
  18. Cappuccio F., Cooper D., D'Elia L. et al. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J. 2011; 32 (12): 1484–92. DOI: 10.1093/eurheartj/ehr007
  19. Bjelakovic G., Nikolova D., Lotte Gluud L. et al. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2008; 2: CD007176. DOI: 10.1002/14651858.CD007176
  20. Moore S., Patel A., Charles E. et al. Leisure time physical activity of moderate to vigorous intensity and mortality: a large pooled cohort analysis. PLoS Med. 2012; 9 (11): e1001335. DOI: 10.1371/journal.pmed.1001335
  21. Gronek P., Wielinski D., Cyganski P. et al. A Review of Exercise as Medicine in Cardiovascular Disease: Pathology and Mechanism. Aging Dis. 2020; 11 (2): 327–40. DOI: 10.14336/AD.2019.0516
  22. Schöffel N., Senff T., Gerber A. et al. Intermittent hypoxic training – the state of science [Article in German]. Pneumologie. 2008; 62 (5): 279–83. DOI: 10.1055/s-2008-1038113
  23. Levine B. High Intermittent hypoxic training: fact and fancy. Alt Med Biol. 2002; 3 (2): 177–93. DOI: 10.1089/15270290260131911
  24. Pham V.T., Dold S., Rehman A. et al. Vitamins, the gut microbiome and gastrointestinal health in humans. Nutr Res. 2021; 95: 35–53. DOI: 10.1016/j.nutres.2021.09.001
  25. Rowland I., Gibson G., Heinken A. et al. Gut microbiota functions: metabolism of nutrients and other food components. Eur J Nutr. 2018; 57 (1): 1–24. DOI: 10.1007/s00394-017-1445-8
  26. Proctor L. What’s next for the human microbiome? Nature. 2019; 569 (3): 623–5. DOI: 10.1038/d41586-019-01654-0
  27. Hoffmann M., Kleine-Weber H., Schroeder S. et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020; 181 (2): 271–280.e8. DOI: 10.1016/j.cell.2020.02.052
  28. Duboc H., Rajca S., Rainteau D. et al. Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases. Gut. 2013; 62 (4): 531–9. DOI: 10.1136/gutjnl-2012-302578
  29. Ahlawat S., Asha, Sharma K.K. Gut-organ axis: a microbial outreach and networking. Lett Appl Microbiol. 2021; 72 (6): 636–68. DOI: 10.1111/lam.13333
  30. Bosco N., Noti M. The aging gut microbiome and its impact on host immunity. Genes Immun. 2021; 22 (5-6): 289–303. DOI: 10.1038/s41435-021-00126-8
  31. Ahlawat S., Asha, Sharma K.K. Immunological co-ordination between gut and lungs in SARS-CoV-2 infection. Virus Res. 2020; 286: 198103. DOI: 10.1016/j.virusres.2020.198103
  32. Kuwahara A., Matsuda K., Kuwahara Y. et al. Microbiota-gut-brain axis: enteroendocrine cells and the enteric nervous system form an interface between the microbiota and the central nervous system. Biomed Res. 2020; 41 (5): 199–216. DOI: 10.2220/biomedres.41.199
  33. Wastyk H.C., Fragiadakis G.K., Perelman D. et al. Gut-microbiota-targeted diets modulate human immune status. Cell. 2021; 184 (16): 4137–4153.e14. DOI: 10.1016/j.cell.2021.06.019