Selenium, selenium-containing drugs, antioxidant action: possibility of application in clinical practice

DOI: https://doi.org/10.29296/25877305-2022-11-15
Issue: 
11
Year: 
2022

Professor D. Dedov, MD
Tver State Medical University
Tver Regional Clinical Cardiology Dispensary

Aim: to study the literature data reflecting the antioxidant effect of selenium (Se) and the possibility of using selenium-containing preparations in clinical practice. Material and methods. The analysis of 33 foreign and Russian publications reflecting antioxidant action of Se and possibility of application of selenium-containing preparations in clinical practice was performed. Results. The problem of Se deficiency in nature is very topical. Se had antioxidant action, participated in improvement of immune functions, metabolic homeostasis. Increased Se concentration was associated with decreased serum total cholesterol and triglycerides. Optimal Se intake is important for normal reproductive function in men and women. The risk of Se deficiency increased in proportion to age. Decreased levels of certain selenoproteins could be associated with an increased likelihood of Parkinson's disease, Alzheimer's disease, and epilepsy. Conclusions. Plants were the main dietary source of Se for populations in most countries. They were able to metabolize and accumulate organic Se in edible parts for consumption. Russian SELENBIO for women selenium-containing complex could be useful to compensate for Se deficiency in elderly patients. This allowed to prevent the growth of oxidative stress – one of the leading mechanisms of aging.
Keywords: 
therapy
selenium
selenium-containing preparations
antioxidant effect
application
clinical practice
Parapharm company
SELENBIO for women

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