COUGH IN A PATIENT IN GENERAL MEDICAL PRACTICE. WHAT TO PAY ATTENTION TO?

DOI: https://doi.org/10.29296/25877305-2022-11-02
Issue: 
11
Year: 
2022

Professor E. Borodulina(1), MD; L. Katina(1), S. Soldatova(2)
1-Samara State Medical University, Ministry of Health of Russia
2-Togliatti City Clinical Polyclinic Third

Cough is a widespread symptom that negatively affects the quality of life of patients, as well as leading to serious complications. Cough as a symptom accompanies not only respiratory diseases, but also occurs in the pathology of many other organs and systems, such as the digestive system, ENT organs, etc. This is due to the direct irritation of cough receptors in diseases and stimulation of the cough center. In the absence of clinical signs of a specific disease, the diagnostic search for chronic cough is a consistent exclusion of the most common causes. For diagnosis, a thorough assessment of the nature of the cough is important. Only an accurate interpretation of it will contribute to the early start of rational highly effective therapy, which will reduce the risk of complications.

Keywords: 
cough
disease
respiratory tract
aspiration
sputum
bronchitis



References: 
  1. Zaitsev A.A. Cough: problems and solutions. Prakticheskaya pul'monologiya. 2020; 2: 78–86 (in Russ.).
  2. Budnevskiy A.V., Ovsyannikov E.S., Shkatova Y.S. et al. Cough: the evolution of views and modern approaches to an objective assessment. Therapeutic Archive. 2019; 91 (3): 71–5 (in Russ.). DOI: 10.26442/00403660.2019.03.000111
  3. Chuchalin A.G., Abrosimov V.N. Kashel'. M.: GEOTAR-Media, 2016; 160 р. (in Russ.).
  4. Evans R.A., McAuley H., Shikotra A. et al. Correction to Lancet respir med. Lancet Respir Med. 2021; 9 (12): 114. DOI: 10.1016/S2213-2600(21)00515-4
  5. Osipova G.L., Osipova V.V., Terekhov D.V. et al. Cough and Cough Variant Asthma. Prakticheskaya pul'monologiya. 2019; 2: 3–7 (in Russ.).
  6. Ovsyannikov E.S., Аvdeev S.N., Budnevskiy A.V. et al. Cough Diagnosis: Present and Future. Tuberculosis and Lung Diseases. 2021; 99 (11): 56–64 (in Russ.). DOI: 10.21292/2075-1230-2021-99-11-56-64
  7. Chung K.F., McGarvey L., Song W.J. et al. Cough hypersensitivity and chronic cough. Nat Rev Dis Primers. 2022; 8 (1): 45. DOI: 10.1038/s41572-022-00370-w
  8. Dobrykh V.A., Mamrovskaya T.P., Dyachenko O.A. et al. Cough syndrome (lecture). Far Eastern medical journal. 2022; 2: 86–91 (in Russ.). DOI: 10.35177/1994-5191-2022-2-15
  9. Kiselev V.V., Lukashevich M.G. Cough as a sign of post-nasal drip syndrome. Russian Rhinology. 2020; 28 (1): 10–4 (in Russ.). DOI: 10.17116/rosrino20202801110
  10. Sinopal'nikov A.I., Klyachkina I.L. Karmannye rekomendatsii dlya vrachei po vedeniyu patsientov s kashlem. M., 2016; р. 175 (in Russ.).
  11. Zaitsev A.A., Leshchenko I.V., Malyavin A.G. Acute bronchitis – project of clinical guidelines. Therapy. 2022; 8 (5): 86–95 (in Russ.). DOI: 10.18565/therapy.2022.5.86-95
  12. Avdeev S.N., Belotserkovskiy B.Z., Dehnich A.V. et al. Modern approaches to the diagnostics, treatment and prevention of severe community-acquired pneumonia in adults: a review. Annals of Critical Care. 2021; 3: 27–46 (in Russ.). DOI: 10.21320/1818-474X-2021-3-27-46
  13. Chung K.F, Pavord I.D. Prevalence, pathogenesis, and causes of chronic cough. Lancet. 2008; 371 (9621): 1364–74. DOI: 10.1016/S0140-6736(08)60595-4
  14. On P.C. Overview of chronic cough. Am J Manag Care. 2022; 28 (9 Suppl): 152–8. DOI: 10.37765/ajmc.2022.89243
  15. Zaccone E.J., Lieu T., Muroi Y. et al. Parainfluenza 3 - induced cough hypersensitivity in the guinea pig airways. PLoS One. 2016; 11 (5): e0155526. DOI: 10.1371/journal.pone.0155526
  16. Tajmazova A.S., Ikaev Z.E., Boradzova A.V. Cough associated with viral respiratory infections. problems and solutions. Molodoi uchenyi. 2021; 5 (347): 98–100 (in Russ.).
  17. Andersson C., Bonvini S.J., Horvath P. et al. Research highlights from the 2017 ERS International Congress: airway diseases in focus. ERJ Open Research. 2018; 4 (1): 00163-2017. DOI: 10.1183/23120541.00163-2017
  18. Osipova V.L. Vnutribol'nichnaya infektsiya: uchebnoe posobie. 2-e izd., ispr. i dop. M.: GEOTAR-Media, 2019; 240 р. (in Russ.).
  19. Chulanov V.P., Gorelov A.V., Malyavin A.G. et al. Ostrye respiratornye virusnye infektsii (ORVI) u vzroslykh. M., 2021 (in Russ.).
  20. Kozlov V.A., Tikhonova E.P., Savchenko A.A. et al. Klinicheskaya immunologiya. Prakticheskoe posobie dlya infektsionistov. Krasnoyarsk: Polikor, 2021; 563 р. (in Russ.).
  21. Kudlay D., Shirobokov Ya., Gladunova E. et al. Diagnosis of COVID-19. Methods and problems of virus SARS-CoV-2 detection under pandemic conditions. Vrach. 2020; 31 (8): 5–10 (in Russ.). DOI: 10.29296/25877305-2020-08-01
  22. Malkova A.M., Kudryavtsev I.V., Starshinova A.A. et al. Post COVID-19 syndrome in patients with asymptomatic/mild form. Pathogens. 2021; 10 (11): 1408. DOI: 10.3390/pathogens10111408
  23. Zaitsev A.A., Okovityi S.V., Miroshnichenko N.A. et al. Kashel': Metodicheskie rekomendatsii dlya vrachei. M.: GVKG im. N.N. Burdenko, 2021; р. 84 (in Russ.).
  24. Arévalo Ruales K., Elkes B., Miehle N. Husten in Corona-Zeiten Cough in times of coronavirus. Z Rheumatol. 2021; 80 (3): 270–3. DOI: 10.1007/s00393-021-00961-0
  25. Song W.J., Hui C.K.M., Hull J.H. et al. Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses. Lancet Respir Med. 2021; 9 (5): 533–44. DOI: 10.1016/S2213-2600(21)00125-9
  26. Yong S.J. Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. Infect. Dis. 2021; 53 (10): 737–54. DOI: 10.1080/23744235.2021.1924397
  27. Savushkina O.I., Cherniak A.V., Kryukov E.V. et al. Follow-up pulmonary function of COVID-19 patients 4 months after hospital discharge. Pulmonologiya. 2021; 31 (5): 580–6 (in Russ.). DOI: 10.18093/0869-0189-2021-31-5-580-587
  28. Fesenko O.V. Cough in the post COVID period: clinical examples. Pulmonologiya. 2021; 31 (3): 375–83 (in Russ.). DOI: 10.18093/0869-0189-2021-31-3-375-382
  29. Zinserling V.A., Vashukova M.A., Vasilyeva M.V. et al. Issues of pathology of a new coronavirus infection CoVID-19. Journal Infectology. 2020; 12 (2): 5–11 (in Russ.). DOI: 10.22625/2072-6732-2020-12-2-5-11
  30. Okovityi S.V., Sukhanov D.S., Zaicev A.A. Cough associated with the new coronavirus infection (COVID-19): rational approaches to pharmacotherapy. Pulmonologiya. 2022; 32 (2): 232–8 (in Russ.). DOI: 10.18093/0869-0189-2022-32-2-232-238
  31. Borodulin B.E., Borodulina E.A., Eremenko E.P. Ambulatornaya ftiziatriya. Uchebnoe posobie. M.: KNORUS, 2022; s. 420 (in Russ.).
  32. Borodulina E.A., Inkova A.T., Borodulin B.E., et al. Ways to optimize detection of tuberculosis in a pulmonology unit. Tuberculosis and Lung Diseases. 2018; 96 (5): 22–6 (in Russ.). DOI: 10.21292/2075-1230-2018-96-5-22-26
  33. Borodulina E.A., Shubina A.T., Gerasimov A.N. et al. GX technologies for rapid diagnosis of tuberculosis in general healthcare network. The Bulletin of Contemporary Clinical Medicine. 2022; 15 (1): 7–16 (in Russ.). DOI: 10.20969/VSKM.2022.15(1).7-16
  34. Borodulina E.V., Borodulina E.A., Gladunova E.P. et al. Medico-social characteristics of newly diagnosed patients with tuberculosis. Meditsinskii al'yans. 2018; 3: 41–6 (in Russ.).
  35. Borodulina E., Skoptsova N., Borodulin B. et al. Difficulties of tuberculosis diagnosis. Vrach. 2018; 29 (2): 30–2 (in Russ.). DOI: 10.29296/25877305-2018-02-07
  36. Borodulina E.A., Kudlay D.A., Kuznetsova A.N. et al. Possibilities of the Enzyme-Linked Immunospot Assay (ELISPOT) method in carrying out anti-tuberculosis measures in patients with HIV infection. Immunologiya. 2021; 42 (5): 536–44 (in Russ.). DOI: 10.33029/0206-4952-2021-42-5-536-544
  37. Slogotskaya L.V., Bogorodskaya E.M., Senchikhina O.Yu. et al. Formation of risk groups for tuberculosis disease in various immunological methods of the examination of children population. Russian Pediatric Journal. 2017; 20 (4): 207–13 (in Russ.). DOI: 10.18821/1560-9561-2017-20-4-207-213
  38. Slogotskaya L.V., Litvinov V., Ovsyankina E. et al. Results of QuantiFERON-TB Gold in-tube and skin testing with recombinant proteins CFP-10-ESAT-6 in children and adolescents with TB or latent TB infection. Paediatric Respiratory Reviews. 2013; 14 (2): S65.
  39. Shovkun L.A., Aksenova V.A., Kudlay D.A. et al. The role of immunological tests in the diagnosis of tuberculosis infection in children with juvenile idiopathic arthritis (JIA). Eur Respir J (Suppl). 2018; 52 (S62): PA2733.
  40. Kudlay D.A., Starshinova A.A., Dovgalyuk I.F. Recombinant tuberculosis allergen: 10 years of experience with the test in children and adolescents in the Russian Federation (meta analysis data). Pediatria n.a. G.N. Speransky. 2020; 99 (3): 121–9 (in Russ.). DOI: 10.24110/0031-403X-2020-99-3-121-129
  41. Kudlay D.A., Doktorova N.P. ESAT-6 and CFP-10 antigens as a biotechnology molecule substrate. applications in medicine. Russian Journal of Infection and Immunity. 2022; 12 (3): 439–49 (in Russ.). DOI: 10.15789/2220-7619-EAC-1763
  42. Dicpinigaitis P. Understanding the foundations of chronic cough. Am J Manag Care. 2020; 26 (11 Suppl): 232–8. DOI: 10.37765/ajmc.2020.88514
  43. Morice A.H., Millqvist E., Bieksiene K. et al. ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. Eur Respir J. 2020; 55 (1): 1901136. DOI: 10.1183/13993003.01136-2019
  44. Sadeghi M.H., Wright C.E., Hart S. et al. Does FeNO predict clinical characteristics in chronic cough? Lung. 2018; 196 (1): 59–64. DOI: 10.1007/s00408-017-0074-6
  45. Borodulina E.A., Vdoushkina E.S., Yakovleva E.V. Lung Injury in COVID-19 and Pneumocystis Pneumonia. Similarities and Differences. Tuberculosis and Lung Diseases. 2022; 100 (9): 59–64 (in Russ.). DOI: 10.21292/2075-1230-2022-100-9-59-64
  46. Orlova N.V. Chronic cough: differential diagnosis and treatment. Medical Council. 2020; 17: 124–31 (in Russ.). DOI: 10.21518/2079-701X-2020-17-124-131
  47. Nikitin V.A., Marks S.I., Tolstykh E.M. et al. Clinical phenotypes of cough reflex and their correction. Pulmonologiya. 2016; 26 (2): 238–45 (in Russ.). DOI: 10.18093/0869-0189-2016-26-2-238-245
  48. Kapkova M.M. Tselesoobraznost' primeneniya protivokashlevykh preparatov pri «sukhom» kashle. Bulletin of Scientific Conferences. 2019; 3-3 (43): 73–4 (in Russ.).
  49. Zaitsev A.A., Belotserkovskaya Yu.G. Mucoactive and antitussive therapy of acute respiratory diseases in real clinical practice. Prakticheskaya pul'monologiya. 2021; 2: 75–81 (in Russ.). DOI: 10.24412/2409-6636-2021-12694
  50. Deliagin V.M. Choice of therapy for coughing (spiral development). Medical Council. 2019; 11: 60–6 (in Russ.). DOI: 10.21518/2079-701X-2019-11-60-66
  51. Avdeev S.N., Demko I.V., Zaytsev A.A. et al. Federal guidelines on diagnosis and treatment of chronic bronchitis. Pulmonologiya. 2022; 32 (3): 448–72 (in Russ.). DOI: 10.18093/0869-0189-2022-32-3-448-472
  52. Avdeev S.N., Demko I.V., Zaitsev A.A. et al. Khronicheskii bronkhit. Klinicheskie rekomendatsii. M., 2021 (in Russ.).
  53. Prokhorovich E.A., Silina E.G. Medicinal products for the treatment of cough and diseases associated with sputum. RMJ. Medical Review. 2019; 9 (1): 25–8 (in Russ.).
  54. Zaitsev A.A., Vizel A.A., Shakirova G.R. et al. Clinical efficacy of Rengalin cough-suppressant therapy in patients with new coronavirus infection (COVID-19). The Bulletin of Contemporary Clinical Medicine. 2022; 15 (4): 33–43 (in Russ.). DOI: 10.20969/VSKM.2022.15(4).33-43