HAC (Russian)
RSCI (Russian)
Ulrichsweb (Ulrich’s Periodicals Directory)
Scientific Indexing Services


DOI: https://doi.org/10.29296/25877305-2022-10-10

A. Astapovskiy; O. Zhukova, Сandidate of Medical Sciences; Professor V. Drozdov, MD; Professor E. Shikh, MD
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Aim: to provide a brief overview of the metabolic effects of vitamin U, as well as current clinical studies on its effectiveness in various pathological conditions. Key points. S-methylmethionine, better known as vitamin U, is a metabolic substrate that affects many metabolic processes in the human body. It was first discovered in the 50s of the last centuries in cabbage juice. Since then, a large number of pre-clinical and clinical studies have been produced that have demonstrated the safety and effectiveness of vitamin U in various diseases. gastroprotective, hypolipidemic, antioxidant and organoprotective properties of vitamin U. In this review, more attention is paid to the gastroprotective properties of S-methylmethionine. Nevertheless, data are presented demonstrating its hypolipidemic, antioxidant and organoprotective properties, which allow the possibility of expanding the scope of its application in the future. Conclusion. The accumulated data on the effectiveness of vitamin U allow us to consider it as an adjunct to the main therapy of gastritis and ulcers in order to increase efficiency, as well as a means to prevent exacerbations.

vitamin U

  1. Kim K., Kim J., Kim M. et al. Effect of Enhancers on in vitro and in vivo Skin Permeation and Deposition of S-Methyl-L-Methionine. Biomol Ther (Seoul). 2017; 25 (4): 434–40. DOI: 10.4062/biomolther.2016.254
  2. Cheney G. Anti-Peptic Ulcer Dietary Factor (Vitamin “U”) in the Treatment of Peptic Ulcer. J Am Diet Assoc. 1950; 26 (9): 668–72. DOI: 10.1016/s0002-8223(21)30396-0
  3. Patel A., Prajapati N. Review on biochemical importance of vitamin-U. J Chem Pharm Res. 2012; 4 (1): 209–15.
  4. Normy fiziologicheskoi potrebnosti (MR (in Russ.). URL: https://docs.cntd.ru/document/1200076084
  5. Kim G. Determination of Vitamin U in Food Plants. Food Science and Technology Research. 2003; 9 (4): 316–9. DOI: 10.3136/fstr.9.316
  6. Nakamura N., Uzawa H. Hypolipidemic effect of L-form S-methylmethionine sulfonium chloride in man. Arzneimittelforschung. 1981; 31 (4): 725–9.
  7. Seri K., Amemiya K., Sugimoto H. et al. Effects of S-methylmethionine (vitamin U) on experimental nephrotic hyperlipidemia. Arzneimittelforschung. 1979; 29 (10): 1517–20.
  8. Lee N., Park K., Min H. et al. Inhibitory Effect of Vitamin U (S-Methylmethionine Sulfonium Chloride) on Differentiation in 3T3-L1 Pre-adipocyte Cell Lines. Ann Dermatol. 2012; 24 (1): 39. DOI: 10.5021/ad.2012.24.1.39
  9. Gessler N.N., Kharchenko L.I., Pavlovskaya T.E. et al. Antiradiation effects of S-methylmethionine (vitamin U). Applied Biochemistry and Microbiology. 1996; 32 (6): 599–601.
  10. Tunali S., Kahraman S., Yanardag R. Vitamin U, a novel free radical scavenger, prevents lens injury in rats administered with valproic acid. Hum Exp Toxicol. 2014; 34 (9): 904–10. DOI: 10.1177/0960327114561665
  11. Sokmen B., Tunali S., Yanardag R. Effects of vitamin U (S-methyl methionine sulphonium chloride) on valproic acid induced liver injury in rats. Food Chem Toxicol. 2012; 50 (10): 3562–6. DOI: 10.1016/j.fct.2012.07.056
  12. Kim W., Yang Y., Min H. et al. Accelerated Wound Healing by S-Methylmethionine Sulfonium: Evidence of Dermal Fibroblast Activation via the ERK1/2 Pathway. Pharmacology. 2010; 85 (2): 68–76. DOI: 10.1159/000276495
  13. Kim W., Seo H., Kim W. et al. The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin. Int J Mol Sci. 2015; 16 (8): 17088–100. DOI: 10.3390/ijms160817088
  14. Liu H., Lu P., Guo Y. et al. An integrative genomic analysis identifies as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity. Genome Res. 2009; 20 (1): 28–35. DOI: 10.1101/gr.097212.109
  15. Watanabe T., Ohara S., Ichikawa T. et al. Mechanisms for cytoprotection by vitamin U from ethanol-induced gastric mucosal damage in rats. Dig Dis Sci. 1996; 41 (1): 49–54. DOI: 10.1007/bf02208583
  16. Ichikawa T., Ito Y., Saegusa Y. et al. Effects of combination treatment with famotidine and methylmethionine sulfonium chloride on the mucus barrier of rat gastric mucosa. J Gastroenterol Hepatol. 2009; 24 (3): 488–92. DOI: 10.1111/j.1440-1746.2008.05667.x
  17. Suzue R. Bulletin of the Institute for Chemical Research, Kyoto University. 1967; 45: 201.
  18. Hikichi T., Sato M., Watanabe K. et al. Peptic Ulcers in Fukushima Prefecture Related to the Great East Japan Earthquake, Tsunami and Nuclear Accident. Intern Med. 2018; 57 (7): 915–21. DOI: 10.2169/internalmedicine.9252-17
  19. Salim A. Administration of Sulfhydryls to Stimulate the Healing of Ischemia-Induced Acute Gastric Mucosal Injury in the Rat. J Pharm Sci. 1991; 80 (6): 539–41. DOI: 10.1002/jps.2600800607
  20. Peterson W., Ciociola A., Sykes D. et al. Ranitidine bismuth citrate plus clarithromycin is effective for healing duodenal ulcers, eradicating H. pylori and reducing ulcer recurrence. RBC H. pylori Study Group [see comments]. Aliment Pharmacol Ther. 1996; 10 (3): 251–61. DOI: 10.1111/j.0953-0673.1996.00251.x
  21. Drozdov V.N., Shikh E.V., Starodubtseva A.K. et al. Chronic gastritis and idiopathic peptic ulcer – the prospects of using S-methylmethionine (vitamin U) in complex therapy. Trudnyi patsient. 2018; 6 (16): 12–8 (in Russ.).
  22. Dietology. Guide. 5th ed. Under the editorship of A.Yu. Baranovsky. SPb: Peter, 2017; 1104 p. (in Russ.).
  23. Niv Y. Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers. World J Gastroenterol. 2014; 20 (40): 14913. DOI: 10.3748/wjg.v20.i40.14913
  24. Mansurov H.H., Pinhasov I.I. Results of a clinical trial of vitamin U in peptic ulcer and chronic gastritis. Vitamin U (S-methylmethionine). Nature, properties, application. M.: Nauka, 1973; р. 53–60 (in Russ.).
  25. Frank Yu.P., Korzhukova P.I. The use of vitamin U in patients with duodenal ulcer and chronic gastritis. Duodenal ulcer (pathogenesis, diagnosis, treatment). M., 1981; р. 110–6 (in Russ.).
  26. Nesterova A.P., Taitz N.S., Gurvich M.M. et al. The value of vitamin U in the complex treatment of hyperacid gastritis and duodenitis. Institute of Nutrition of the USSR Academy of Medical Sciences, 1973; р. 108–12 (in Russ.).
  27. Trusov V.V., Oreshkov T.M. Experience in the treatment of patients with chronic gastritis with vitamin U "Vitamin U (S-methylmethionine) (nature, properties, application)". M.: Nauka, 1973; р. 112–9 (in Russ.).
  28. Anisomiov V.E. The effectiveness of the use of the domestic preparation of vitamin U peptic ulcer of the stomach and duodenum. Vitamin U (S-Methylmethionine). Nature, properties, application. M.: Nauka, 1973; р. 64–71 (in Russ.)