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Staphylococcus aureus and its role in the development of surgical site infection

DOI: https://doi.org/10.29296/25877305-2022-10-05

A. Morozov, Candidate of Medical Sciences; A. Sergeev, MD; S. Zhukov, MD;
A. Morozova; M. Muravlyantseva; E. Sobol
Tver State Medical University, Ministry of Health of Russia

Surgical site infections (SSIs) are one of the most common healthcare-associated problems. The paper reviews literature on the problem of SSI and gives its prevalence and causes. Staphylococcus aureus is one of the most common pathogens of SSI. The spread of methicillin-resistant Staphylococcus aureus (MRSA) strains is an urgent public health problem. Understanding the epidemiology and population structure of MRSA is essential to control its spread and to develop therapeutic strategies and methods for the prevention of life-threatening infections, including SSI.

pyoseptic complications
Staphylococcus aureus
methicillin-resistant Staphylococcus aureus

  1. Byval'tsev V.A., Stepano I.A., Borisov V.E. et al. Surgical site infections in spinal neurosurgery. Kazan Medical Journal. 2017; 5: 796–803 (in Russ). DOI: 10.17750/KMJ2017-796
  2. Smekalenkov O.A., Ptashnikov D.A., Bozhkova S.A. et al. Analysis of early infectious complications in patients after spinal surgery. Spine Surgery. 2017; 14 (2): 82–7 (in Russ.). DOI: 10.14531/ss2017.2.82-87
  3. Krylov N.N., Pyatenko E.A. Influence of infection in the area of surgical interference on the results of treatment of the patients having colorectal cancer. Meditsinskii al'manakh. 2016; 3 (43): 21–3 (in Russ.).
  4. Stepin A.V., Matveev S.A., Mamontov D.A. The Prevalence of Wound Complications after Cardiac Surgery. Epidemiology and Vaccinal Prevention. 2020; 19 (6): 101–7 (in Russ.). DOI: 10.31631/2073-3046-2020-19-6-101-107
  5. Shlepotina N.M., Timakova V.A. Application of suture material and development of surgical site infections: opinion of n.i. pirogov and modern state of this problem. Vestnik Soveta molodykh uchenykh i spetsialistov Chelyabinskoi oblasti. 2016; 4 (15): 159–61 (in Russ.).
  6. Tong S.Y., Davis J.S., Eichenberger E. et al. Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev. 2015; 28 (3): 603–61. DOI: 10.1128/CMR.00134-14
  7. Laupland K.B., Lyytikäinen O., Søgaard M. et al. The changing epidemiology of Staphylococcus aureus bloodstream infection: a multinational population-based surveillance study. International Bacteremia Surveillance Collaborative. Clin Microbiol Infect. 2013; 19 (5): 465–71. DOI: 10.1111/j.1469-0691.2012.03903.x
  8. Zyryanov S.K., Sychev I.N., Gushchina Yu.S. Current Problems of Infections Caused by MRSA and Ways to Address Them. Antibiotics and Chemotherapy. 2017; 62 (7-8):69–79 (in Russ.).
  9. Gostev, V.V. Sidorenko S.V. Methicillin-resistant staphylococcus aureus: the problem of expantion in the world and in Russia. Farmateka. 2015; 6: 30–8 (in Russ.).
  10. Balasubramanian D., Harper L., Shopsin B. et al. Staphylococcus aureus pathogenesis in diverse host environments. Pathog Dis. 2017; 75 (1): ftx005. DOI: 10.1093/femspd/ftx005
  11. Bozhkova S.A., Bogdanova T.Ya., Krasnova M.V. et al. Experimental and clinical study of phenotypic features of S. epidermidis strains and their role in the emergence and development of implant-associated infection after orthopaedic surgery. Traumatology and Orthopedics of Russia. 2014; 2 (72): 68–77 (in Russ.).
  12. Cheung G.Y.C., Bae J.S., Otto M. Pathogenicity and virulence of Staphylococcus aureus. Virulence. 2021; 12 (1): 547–69. DOI: 10.1080/21505594.2021.1878688
  13. Morozov A.M., Sergeev A.N. Diagnosis and prophylaxis of infectious complications in surgical intervention zone. Bulletin of the Ivanovo Medical Academy. 2021; 1 (26): 54–8 (in Russ.). DOI: 10.52246/1606-8157_2021_26_1_54
  14. Sharkov S.M., Ikhsanova S.R. Use of triclosan-coated suture material as prevention of surgical site infections (literature review). Wounds and wound infections. The prof. B.M. Kostyuchenok journal. 2021; 8 (2): 28–32 (in Russ.). DOI: 10.25199/2408-9613-2021-8-2-28-32
  15. Popov D.A. Unresolved issues of antibiotic therapy of infections caused by Staphylococcus aureus. Clinical Microbiology and Antimicrobial Chemotherapy. 2020; 22(3):189-195 (in Russ.). DOI: 10.36488/cmac.2020.3.189-195
  16. Morata L., Alejo I., Fernandez I. et al. Predictors of persistent S. aureus bacteraemia and impact in related mortality. European Congress of Clinical Microbiology and Infectious Diseases, 2014; eP098.
  17. Romanov A.V., Dekhnich A.V., Sukhorukova M.V. et al. Antimicrobial resistance of nosocomial Staphylococcus aureus isolates in Russia: results of multicenter epidemiological study «MARATHON» 2013–2014. Clinical Microbiology and Antimicrobial Chemotherapy. 2017; 19 (1): 57–62 (in Russ.).
  18. Bozhkova S.A., Polyakova E.M., Krasnova M.V. The breaking of resistance to gentamycin in methicillin resistant staphylococcus aureus strains. International journal of applied and fundamental research. 2017; 8 (1): 97–103 (in Russ.).
  19. Romanov A.V., Chernov E.A., Edelstein M.V. Molecular epidemiology of nosocomial Staphylococcus aureus in hospitals in different regions of Russia. Molecular medicine. 2013; 4: 55–64 (in Russ.).
  20. Schurig-Briccio L.A., Parraga Solorzano P.K., Lencina A.M. et al. Role of respiratory NADH oxidation in the regulation of Staphylococcus aureus virulence. EMBO Rep. 2020; 21 (5): e45832. DOI: 10.15252/embr.201845832
  21. Kazemzadeh-Narbat M., Lai B.F.L., Ding C. et al. Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections. Biomaterials. 2013: 34 (24); 5969–77. DOI: 10.1016/j.biomaterials.2013.04.036
  22. Phipps A., Vaynshteyn E., Kowalski J.B. et al. Chemical sterilization of allograft dermal tissues. Cell Tissue Bank. 2017; 18 (4): 573–84. DOI: 10.1007/s10561-017-9647-0
  23. Shang X., Wang H., Li J. et al. Progress of sterilization and preservation methods for allografts in anterior cruciate ligament reconstruction. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2019; 33 (9): 1102–7. DOI: 10.7507/1002-1892.201903078
  24. Vorobyоv K.A., Bozhkova S.A., Tikhilov R.M. et al. Current Methods of Processing and Sterilization of Bone Allografts (Review of Literature). Traumatology and Orthopedics of Russia. 2017; 23 (3): 134–47 (in Russ.). DOI: 10.21823/2311-2905-2017-23-3-134-147
  25. Mokhov E.M., Lyubskij I.V., Sergeev А.N. et al. The Opportunities for Developing a New Biologically Active Suture Material in Surgery. Journal of experimental and clinical surgery. 2019; 12 (3): 193–8 (in Russ.). DOI: 10.18499/2070-478X-2019-12-3-193-198
  26. Fowler V.G., Proctor R.A. Where does a Staphylococcus aureus vaccine stand? Clin Microbiol Infect. 2014; 20 (5): 66–75. DOI: 10.1111/1469-0691.12570
  27. Miller L.S., Fowler V.G., Shukla S.K. et al. Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms. FEMS Microbiol Rev. 2020; 44 (1): 123–53. DOI: 10.1093/femsre/fuz03