The impact of Equapress therapy on cardiac remodeling and myocardial ischemia in premenopausal patients with hypoestrogenemia

DOI: https://doi.org/10.29296/25877305-2022-09-03
Issue: 
9
Year: 
2022

M. Khabibulina, Candidate of Medical Sciences; M. Shamilov
Ural State Medical University, Yekaterinburg

Objective. To investigate the impact of therapy with the combination drug Equapress on cardiac remodeling and silent myocardial ischemia (SMI) in premenopausal women with hypertension and estradiol deficiency. Subjects and methods. The investigation involved 47 premenopausal patients (mean age 47.80±2.37 years) with Stage II essential hypertension and estradiol deficiency, who were prescribed the combination drug Equapress (lisinopril, amlodipine, and indapamide long) as an antihypertensive agent. Before the start of the investigation and at 6 months after therapy, the patients underwent echocardiography, an analysis of the structural and geometric parameters of the left heart chambers, and an assessment of the systolic and diastolic functions of the left ventricle (LV). Holter monitoring was done with a Kardiotekhnika cardiomonitor complex to detect SMI. Results. Triple antihypertensive therapy (lisinopril, amlodipine, and indapamide long) in premenopausal patients with hypertension and estrogen deficiency can slow down the development of LV hypertrophy and left heart chamber dilatation, also has a positive impact on LV remodeling, and lowers the incidence of SMI.

Keywords: 
cardiology
premenopause
estrogen deficiency
cardiac remodeling
silent myocardial ischemia
Equapress



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