Clinical and morphological aspects of bladder cancer in elderly and senile ages

DOI: https://doi.org/10.29296/25877305-2022-06-12
Issue: 
6
Year: 
2022

Professor T. Pavlova, MD; I. Pavlov, Candidate of Medical Sciences; Professor
N. Pilkevich, MD; D. Bessmertnyi, Candidate of Medical Sciences; V. Markovskaya Candidate of Biological Sciences
Belgorod State National Research University

The clinical and morphological features of the course of bladder cancer (BC) were studied in 152 middle-aged, elderly, and senile male (86.9%) and female (13.1%) patients diagnosed with Stage I-IV BC: stage I in 116 (76.3%) patients and Stages II, III, IV in 36 (23.7%). Most patients underwent transurethral resection. Moderately differentiated bladder tumor was observed in 54.6% of patients. Microscopic examination of the tumor revealed an ordered his-tological and cellular structure with minor signs of nuclear atypia. Carcinomas consisted of cells with impaired polarity, which had lost intercellular contacts with large hyperchromatic nuclei. There were commonly mitotic figures, often atypical ones. There were no tumor histologic differ-ences in different age groups (middle-aged, elderly and senile patients)
Keywords: 
oncology
bladder cancer
elderly age
histology

References: 
  1. Novikov A.I., Leonenkov R.V., Temkin D.B. et al. Transurethral resection of bladder cancer involving the orifice of the ureter. Onkourologiya = Cancer Urology. 2021; 17 (2): 104–11 (in Russ.). DOI: 10.17650/1726-9776-2021-17-2-104-111
  2. Tsedenova K.O., Komarov M.I., Panakhov A.D. et al. Small-cell bladder cancer: literature review. Onkourologiya = Cancer Urology. 2018; 14 (4): 103–9 (in Russ.). DOI: 10.17650/1726-9776-2018-14-4-103-109
  3. The state of oncological care for the population of Russia in 2020. Ed. A.D. Kaprina, V.V. Starinsky, A.O. Shakhzadova. M.: MNIOI im. P.A. Herzen – a branch of the Federal State Budgetary Institution NMITs Radiology of the Ministry of Health of Russia. 2021; 239 (in Russ.).
  4. Kogan M.I. Bladder cancer (classics and innovations). M.: Medcongress. 2019; 288 (in Russ.).
  5. Belyakova L.I., Shevchenko A.N., Sagakyants A.B., et al. Markers of bladder cancer: their role and prognostic significance (literature review). Onkourologiya = Cancer Urology. 2021; 17 (2): 145–56 (in Russ.). DOI: 10.17650/1726-9776-2021-17-2-145-156
  6. Karyakin O.B. Bladder cancer: what’s new in 2019–2020. Onkourologiya = Cancer Urology. 2020; 16 (4): 147–54 (in Russ.). DOI: 10.17650/1726-9776-2020-16-4-147-154
  7. Oncogerontology. Guide for doctors. Ed. V.N. Anisimova, A.M. Belyaev. St. Petersburg: Publishing house ANNMO «Issues of oncology», 2017; 509 (in Russ.).
  8. Pavlova T.V., Pilkevich N.B., Bessmertny D.V. et al. Features of metabolic atypism during the development of oncological pathology of the urogenital system. Molecular medicine. 2021; 19 (31): 30–4 (in Russ.). DOI: 10.29296/24999490-2021-01-04