ARTERIAL HYPERTENSION IN PERIMENOPAUSE: EFFECTS OF LISINOPRIL AND FEMO-CLIM COMBINATION ON THE HYPOTENSIVE EFFECT, FUNCTIONAL STATE OF ENDOTHELIUM, CARDIAC REMODELING AND QUALITY OF LIFE

DOI: https://doi.org/10.29296/25877305-2022-02-06
Issue: 
2
Year: 
2022

M. Khabibulina, Candidate of Medical Sciences; M. Shamilov Urals State Medical University,
Yekaterinburg

The paper presents the experience of combined therapy with an angiotensin-converting enzyme inhibitor (lisinopril) and Femo-Clim in female patients with arterial hypertension (AH) and its effects on the structural geometric changes of left ventricle (LV), endothelium-dependent vasodilation (EVD) of peripheral arteries, blood pressure (BP) values, the marked clinical manifestations of perimenopause. Material and methods. The study followed 77 women with stage II AH during perimenopause with left ventricular myocardial hypertrophy (LVMH) and peripheral arterial endothelial dysfunction. Mean age was 50.3±4.2 years, mean systolic BP was 171.67±2.81 mm Hg, diastolic BP, 99.7±0.63 mm Hg; mean estradiol level, 0.20±0.05 pkg/mL; mean follicle-stimulating hormone, 24.89±1.12 IU/mL; complaints of hyperhidrosis, hot flashes, disturbance of the general sense of well-being, uneasy sleep, poor appetite and impaired mood. Patients received lisinopril 10 mg daily for 6 months and Femo-Clim 2 tablets daily for 1 month. The patients’ condition was monitored: BP, heart rate, ECG, EKVD test, echocardiography. The study did not include patients with coronary heart disease, chronic heart failure, dyslipidemia, diabetes mellitus, and renovascular disease. Results. The use of lisinopril in patients with AH during perimenopause showed a good antihypertensive effect, slowed the development of LVMH, and had a positive effect on LV remodeling (primarily, on the concentric type). Lysinopril and Femo-Clim combination had a positive effect on peripheral arterial endothelial dysfunction and was well tolerated by the patients. Femo-Klim is combined with cardiotropic therapy and is effective in the therapy of clinical manifestations in patients with AH during perimenopause.
Keywords: 
therapy
cardiology
arterial hypertension
perimenopause
left ventricular myocardial hypertrophy
blood pressure
endothelium-dependent vasodilation
lisinopril
Femo-Klim

References: 
  1. Vinnik T.A. Disfunktsija endotelija u bol'nyh GB v sochetanii s drugimi faktorami riska serdechno-sosudistyh oslozhnenij. Diss. … kand. med. nauk. SPb, 2002 [Vinnik T.A. Disfunktsiya endoteliya u bol’nykh GB v sochetanii s drugimi faktorami riska serdechno-sosudistykh oslozhnenii. Diss. … kand. med. nauk. SPb, 2002 (in Russ.)].
  2. Habibulina M.M. Pokazateli strukturno-funktsional'nogo sostojanija sosudistogo rusla u zhenschin s arterial'noj gipertenziej v period premenopauzy. Ter arh. 2011; 83 (12): 11–5 [Khabibulina M.M. Structural and functional parameters of the vascular bed in premenopausal hypertensive women. Ter arkh. 2011; 83 (12): 11–5 (in Russ.)].
  3. Kolomoets N.M. Endotelial'naja disfunktsija i ee klinicheskoe znachenie: Novoe napravlenie v kardiologii. Voenno-meditsinskij zhurnal. 2002; 5: 29–35 [Kolomoets N.M. Endotelial’naya disfunktsiya i ee klinicheskoe znachenie: Novoe napravlenie v kardiologii. Voenno-meditsinskii zhurnal. 2002; 5: 29–35 (in Russ.)].
  4. Habibulina M.M. Sostojanie sosudistogo rusla u zhenschin s arterial'noj gipertenziej i dislipidemiej v premenopauze pri estrogenodefitsite. Vrach. 2013; 12: 31–6 [Khablbullna M. The vascular bed in premenopausal women with arterial hypertension and dyslipidemia in estrogen deficiency. Vrach. 2013; 12: 31–6 (in Russ.)].
  5. Smetnik V.P., Il'ina L.M. Korrektsija klimaktericheskogo sindroma (individualizatsija terapii). V kn. «Meditsina klimakterija». Litera, 2006; s. 217–74 [Smetnik V.P., Il’ina L.M. Korrektsiya klimaktericheskogo sindroma (individualizatsiya terapii). V kn. «Meditsina klimakteriya». Litera, 2006; s. 217–74 (in Russ.)].
  6. Habibulina M.M. Kardiovaskuljarnyj risk pri estrogenodefitsite v doklimaktericheskih periodah. Ekaterinburg, 2014 [Khabibulina M.M. Kardiovaskulyarnyi risk pri estrogenodefitsite v doklimaktericheskikh periodakh.Yekaterinburg, 2014 (in Russ.)].
  7. Skornjakova M.N. Klinicheskie lektsii po ginekologicheskoj endokrinologii. Rukovodstvo dlja vrachej. Ekaterinburg, 2000; 384 s. [Skornyakova M.N. Klinicheskie lektsii po ginekologicheskoi endokrinologii. Rukovodstvo dlya vrachei. Yekaterinburg, 2000; 384 s. (in Russ.)].
  8. Chazova I.E., Smetnik V.P., Balan V.E. i dr. Vedenie zhenschin s serdechno-sosudistym riskom v peri- i postmenopauze: konsensus rossijskih kardiologov i ginekologov. Consilium medicum. 2008;10 (6): 5–18 [Chazova I.E., Smetnik V.P., Balan V.E. et al. Vedenie zhenshchin s serdechno-sosudistym riskom v peri- i postmenopauze: konsensus rossiiskikh kardiologov i ginekologov. Consilium medicum. 2008;10 (6): 5–18 (in Russ.)].
  9. Pines A. Vasomotor symptoms and cardiovascular disease risk. Climacteric. 2011; 14 (5): 535–6. DOI: 10.3109/13697137.2011.599058
  10. Habibulina M.M. Sravnitel'nyj analiz osobennostej serdechno-bolevogo sindroma i bezbolevaja ishemija miokarda u zhenschin s arterial'noj gipertenziej v period premenopauzy v zavisimosti ot sutochnogo profilja arterial'nogo davlenija. Kardiologija i serdechno-sosudistaja hirurgija. 2011; 4 (3): 55–60 [Khabibulina M.M. Comparative analysis of specifics of cardiac pain syndrome and silent myocardial ischemia in women with arterial hypertension in pre-menopause depending on daily profile of blood pressure. Kardiologiya i serdechno-sosudistaya khirurgiya. 2011; 4 (3): 55–60 (in Russ.)].
  11. Habibulina M.M. Strukturno-geometricheskie izmenenija levyh otdelov serdtsa, sistolicheskaja i diastolicheskaja disfunktsija u zhenschin s arterial'noj gipertenziej v pozdnem fertil'nom periode i period premenopauzy. Kardiologija i serdechno-sosudistaja hirurgija. 2009; 2 (2): 75–8 [Khabibulina M.M. Comparison of structural and geometric changes of the left heart, systolic and diastolic functions in women with hypertension in late fertile period and menopause. Kardiologiya i serdechno-sosudistaya khirurgiya. 2009; 2 (2): 75–8 (in Russ.)].
  12. Habibulina M.M., Shamilov M.D. Bezbolevaja ishemija miokarda u molodyh zhenschin s kardialgiej, disgormonozom i raznoj komorbidnost'ju (serdechnoj i vneserdechnoj). Vrach. 2021; 32 (3): 61–5 [Khabibulina M., Shamilov M. Silent myocardial ischemia in young women with cardialgia, dyshormonosis, and various comorbidities (cardiac and extracardiac ones). Vrach. 2021; 32 (3): 61–5 (in Russ.)]. DOI: 10.29296/25877305-2021-03-11
  13. Veber V.R., Rubanova M.P. i dr. Effektivnost' nebivolola, amlodipina u bol'nyh AG zhenschin v postmenopauze s razlichnymi tipami remodelirovanija levogo zheludochka. Kardiovaskuljarnaja terapija i profilaktika. 2004; 3 (6, ch. 2): 15–9 [Veber V.R., Rubanova M.P. et al. Nebivolol and amlodipine efficacy in postmenopausal hypertensive women with various variants of left ventricular hypertrophy. Kardiovaskulyarnaya terapiya i profilaktika. 2004; 3 (6, ch. 2): 15–9 (in Russ.)].
  14. Glezer M.G. Rezul'taty Rossijskogo issledovanija effektivnosti i bezopasnosti lizinoprila pri AG pod kontrolem sutochnogo monitorirovanija AD. Problemy zhenskogo zdorov'ja. 2007; 2 (1): 1–8 [Glezer M.G. Gender differences in effectiveness and safety of Diroton (lizinopril) treatment of arterial hypertension under diurnal monitoring control of blood pressure. Problems of women health. 2007; 2 (1): 1–8 (in Russ.)].
  15. Kisljak O.A. Ingibitor APF lizinopril v lechenii pozhilyh patsientov s sistolodiastolicheskoj AG. Lechebnoe delo. 2007; 2: 2–7 [Kislyak O.A. Ingibitor APF lizinopril v lechenii pozhilykh patsientov s sistolodiastolicheskoi AG. Lechebnoe delo. 2007; 2: 2–7 (in Russ.)].
  16. Moiseev V.S., Kobalava Zh.D. ARGUS. AG u lits starshih vozrastnyh grupp. Monografija. M.: OOO «MIA», 2002; 448 s. [Moiseev V.S., Kobalava Zh.D. ARGUS. AG u lits starshikh vozrastnykh grupp. Monografiya. M.: OOO «MIA», 2002; 448 s. (in Russ.)].
  17. Tatarenko O.K., Nosenko E.M., Alehin M.N. i dr. Vlijanie ingibitora angiotenzinprevraschajuschego fermenta moeksiprila na tsentral'nuju i perifericheskuju gemodinamiku u zhenschin s umerennoj AG v period menopauzy. Kardiologija. 1999; 39 (1): 48–53 [Tatarenko O.K., Nosenko E.M., Alekhin M.N. et al. Vliyanie ingibitora angiotenzinprevrashchayushchego fermenta moeksiprila na tsentral’nuyu i perifericheskuyu gemodinamiku u zhenshchin s umerennoi AG v period menopauzy. Kardiologiya. 1999; 39 (1): 48–53 (in Russ.)].
  18. Habibulina M.M. Terapija preparatom Ekvator pri gipertonicheskoj bolezni v premenopauzal'nom periode. Vrach. 2010; 7: 25–9 [Khabibulina M. Equator therapy for hypertensive disease in the premenopausal period. Vrach. 2010; 7: 25–9 (in Russ.)].
  19. Schulman S.P., Weiss J.L., Becker L.C. et al. The effect of antihypertensive theraphy on left venrtricular mass in elderly patients. N Engl J Med. 1990; 322: 1350–6. DOI: 10.1056/NEJM199005103221904
  20. Zabalgoitia M., Rahman S.N.V., Haley W.E. et al. Comparison of left ventricular mass and geometric remodeling in treatel and untreated men and women above 50 years of age of age with systemic hypertension. Am J Cardiol. 1997; 80 (5): 648–54. DOI: 10.1016/s0002-9149(97)00443-8
  21. Habibulina M.M. Strukturno-geometricheskie izmenenija levogo zheludochka, endotelij-zavisimaja vazodilatatsija perifericheskih arterij, antigipertenzivnyj effekt ingibitorov angiotenzin-prevraschajuschego fermenta i zamestitel'naja gormonal'naja terapija u zhenschin s arterial'noj gipertenziej v premenopauze. Kardiovaskuljarnaja terapija i profilaktika. 2011; 10 (2): 24–8 [Khabibulina M.M. Left ventricular structure and geometry, peripheral artery endotheliumdependent vasodilatation, antihypertensive effect of ACE inhibitors, and hormone replacement therapy in premenopausal women with arterial hypertension. Cardiovascular Therapy and Prevention. 2011; 10 (2): 24–8 (in Russ.)]. DOI: 10.15829/1728-8800-2011-2-24-28
  22. Ilovajskaja I.A., Vojtashevskij K.V. Menopauzal'naja gormonal'naja terapija: vozmozhnosti i riski. StatusPraesens. Ginekologija. Akusherstvo. Besplodnyj brak. 2015; 5 (28): 80–6 [Ilovaiskaya I.A., Voitashevskii K.V. Menopauzal’naya gormonal’naya terapiya: vozmozhnosti i riski. Status Praesens. Ginekologiya. Akusherstvo. Besplodnyi brak. 2015; 5 (28): 80–6 (in Russ)].
  23. Habibulina M.M., Dmitriev A.N. Sposob optimizatsii lechenija zhenschin kardiotropnoj terapiej i zamestitel'noj gormonal'noj terapiej pri estrogenodefitsite s arterial'noj gipertenziej v pozdnem reproduktivnom periode. Patent na izobretenie RU 2648470 C2, 26.03.2018 Zajavka №2016107890 ot 03.03.2016 [Khabibulina M.M., Dmitriev A.N. Sposob optimizatsii lecheniya zhenshchin kardiotropnoi terapiei i zamestitel’noi gormonal’noi terapiei pri estrogenodefitsite s arterial’noi gipertenziei v pozdnem reproduktivnom periode. Patent na izobretenie RU 2648470 C2, 26.03.2018 Zayavka №2016107890 ot 03.03.2016 (in Russ.)].
  24. Menopauzal'naja gormonal'naja terapija i sohranenie zdorov'ja zhenschin zrelogo vozrasta: Klinicheskie rekomendatsii (protokol lechenija). M.: FGBU NTsGAiP, 2015 [Menopauzal’naya gormonal’naya terapiya i sokhranenie zdorov’ya zhenshchin zrelogo vozrasta: Klinicheskie rekomendatsii (protokol lecheniya). M.: FGBU NTsGAiP, 2015 (in Russ)].
  25. Habibulina M.M. Terapija u zhenschin s arterial'noj gipertenziej i estrogenodefitsitom v pozdnem fertil'nom periode. Vrach. 2016; 4: 45–9 [Khabibulina M. Therapy in women with hypertension and estrogen deficiency in the late fertile period. Vrach. 2016; 4: 45–9 (in Russ.)].
  26. Habibulina M.M. Izmenenija strukturno-geometricheskih pokazatelej, gipotenzivnaja effektivnost' ingibitora angiotenzinprevraschajuschego fermenta lizinoprila u zhenschin s gipertonicheskoj bolezn'ju v period premenopauzy v zavisimosti ot urovnja zhenskih polovyh gormonov. Ural'skij meditsinskij zhurnal. 2008; 9: 74–8 [Khabibulina M.M. Izmeneniya strukturno-geometricheskikh pokazatelei, gipotenzivnaya effektivnost’ ingibitora angiotenzinprevrashchayushchego fermenta lizinoprila u zhenshchin s gipertonicheskoi bolezn’yu v period premenopauzy v zavisimosti ot urovnya zhenskikh polovykh gormonov. Ural’skii meditsinskii zhurnal. 2008; 9: 74–8 (in Russ.)].
  27. Djadyk A.I., Bagrij A.E., Jarovaja N.F. i dr. Vlijanie ingibitorov angiotenzinprevraschajuschego fermenta na gipertrofiju levogo zheludochka serdtsa u bol'nyh arterial'nymi gipertonijami. Ter arh. 1995; 8: 65–7 [Dyadyk A.I., Bagrii A.E., Yarovaya N.F. et al. Vliyanie ingibitorov angiotenzinprevrashchayushchego fermenta na gipertrofiyu levogo zheludochka serdtsa u bol’nykh arterial’nymi gipertoniyami. Ter arkh. 1995; 8: 65–7 (in Russ.)].
  28. Habibulina M.M. Vlijanie trojnoj gipotenzivnoj terapii na remodelirovanie serdtsa, bezbolevuju ishemiju miokarda pri arterial'noj gipertenzii s estrogenodefitsitom v premenopauze. Vrach. 2018; 29 (10): 32–6 [Khabibulina M. Impact of triple antihypertensive therapy on cardiac remodeling, silent myocardial ischemia in hypertension in premenopausal women with estrogen deficiency. Vrach. 2018; 29 (10): 32–7 (in Russ.)]. DOI: 10.29296/25877305-2018-10-09
  29. Karpov Ju.A. Ingibitory APF: ot snizhenija AD do profilaktiki oslozhnenij i uluchshenija prognoza. Serdtse. 2002; 4: 192–4 [Karpov Yu.A. Ingibitory APF: ot snizheniya AD do profilaktiki oslozhnenii i uluchsheniya prognoza. Serdtse. 2002; 4: 192–4 (in Russ.)].
  30. Postnikova S.L. IAPF v kardiologicheskoj praktike. RMZh. 2004; 12 (7): 496–500 [Postnikova S.L. IAPF v kardiologicheskoi praktike. RMJ. 2004; 12 (7): 496–500 (in Russ.)].
  31. Habibulina M.M. Gipotenzivnyj effekt dirotona i ego vlijanie na strukturno-geometricheskie parametry levyh kamer serdtsa u zhenschin s gipertonicheskoj bolezn'ju v period premenopauzy. Vrach. 2008; 9: 59–62 [Khabibulina M.M. Gipotenzivnyi effekt dirotona i ego vliyanie na strukturno-geometricheskie parametry levykh kamer serdtsa u zhenshchin s gipertonicheskoi bolezn’yu v period premenopauzy. Vrach. 2008; 9: 59–62 (in Russ.)].
  32. Mancini G.B., Henry G.C. Angiotensin-Converting Enzyme Inhibition With Quinalapril Improves Endotelial Vasomotor Dysfunction in Patients With Coronary Artery Disease. Circulation. 1996; 94 (3): 258–65. DOI: 10.1161/01.cir.94.3.258
  33. Habibulina M.M. Vlijanie ingibitora angiotenzinprevraschajuschego fermenta lizinoprila na sostojanie sosudistogo rusla u zhenschin s arterial'noj gipertenziej v period premenopauzy. Kardiologija. 2013; 53 (2): 38–42 [Khabibulina M.M. Effect of angiotensin converting enzyme lisinopril on the state of vascular bed in premenopausal women with arterial hypertension. Kardiologiya. 2013; 53 (2): 38–42 (in Russ.)].
  34. Habibulina M.M. Vlijanie kombinirovannogo preparata (lizinopril i gidrohlortiazid) na sostojanie sosudistogo rusla u zhenschin s estrogenodefitsitom. Lechaschij vrach. 2013; 7: 115 [Khabibulina M.M. Influence of the combined preparation (lizinopril and gidrokhlortiazid) on the state of vascular channel in women with estrogeno deficitis and byarterial hypertension in the late fertile period. Lechashchii vrach. 2013; 7: 115 (in Russ.)].
  35. Gold P.H., Machado-Vieira R., Pavlatou M.G. Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress. Neural Plasticity. 2015; 2015: 581976. DOI:10.1155/2015/581976
  36. Habibulina M.M., Shamilov M.D. Kachestvo zhizni molodyh zhenschin s arterial'noj gipertenziej i izmenennym gormonal'nym fonom. Vrach. 2021; 32 (1): 46–9 [Khabibulina M., Shamilov M. Quality of life in young women with hypertension and an altered hormonal background. Vrach. 2021; 32 (1): 46–9 (in Russ.)]. DOI: 10.29296/25877305-2021-01-09
  37. Habibulina M.M. Premenopauza: vlijanie terapii dirotonom i ZGT na kachestvo zhizni pri arterial'noj gipertenzii. Vrach. 2012; 7: 69–71 [Khabibuliria M. Premenopause: impact of diroton therapy and hormone replacement therapy on quality of life in arterial hypertension. Vrach. 2012; 7: 69–71 (in Russ.)].
  38. Habibulina M.M., Smolentseva A.A. Terapija trevozhnyh rasstrojstv u zhenschin s arterial'noj gipertenziej v period premenopauzy na ambulatornom etape. V sb.: V s'ezd kardiologov Ural'skogo federal'nogo okruga. Mat-ly s'ezda. 2011; s. 282–4 [Khabibulina M.M., Smolentseva A.A. Terapiya trevozhnykh rasstroistv u zhenshchin s arterial’noi gipertenziei v period premenopauzy na ambulatornom etape. V sb.: V s»ezd kardiologov Ural’skogo federal’nogo okruga. Mat-ly s»ezda. 2011; s. 282–4 (in Russ.)].
  39. Celemajer D.S., Sorensen K.E., Gooch V.M. et al. Non-invasive detection of endothelial disfunction in adults at risk atherosclerosis. Lancet. 1997; 340 (8828): 1111–5. DOI: 10.1016/0140-6736(92)93147-f
  40. Rybakova M.K., Alehin M.N., Mit'kov V.V. Prakticheskoe rukovodstvo po ul'trazvukovoj diagnostike. Ehokardiografija. M.: Vidar-M, 2008; 512 s. [Rybakova M.K., Alekhin M.N., Mit’kov V.V. Prakticheskoe rukovodstvo po ul’trazvukovoi diagnostike. Ekhokardiografiya. M.: Vidar-M, 2008; 512 s. (in Russ.)].
  41. Staessen J., Ginocchio G. Conventional and ambulatory blood pressure and menopause in a prospective population study. J Hum Hypertens. 1997; 11 (8): 507–14. DOI: 10.1038/sj.jhh.1000476
  42. Staessen J. Menopause and the characteristics of the large arteries in a population study. J Hum Hypertens. 2002; 15 (8): 511–8. DOI: 10.1038/sj.jhh.1001226
  43. Reckelhoff J.F. Gender differences in the regulation of blood pressure. Hypertension. 2001; 37 (5): 1199–208. DOI: 10.1161/01.hyp.37.5.1199
  44. Habibulina M.M. Otsenka vlijanija dlitel'noj terapii ingibitorom angiotenzinprevraschajuschego fermenta lizinoprilom na morfofunktsional'nye pokazateli levogo zheludochka, disfunktsiju endotelija perifericheskih arterij, bezbolevuju ishemiju miokarda u zhenschin s gipertonicheskoj bolezn'ju v period premenopauzy. Kardiologija. 2010; 50 (1): 16–21 [Khabibulina M.M. Evaluation of influence of long-term therapy with angiotensin converting enzyme inhibitor lisinopril on morphofunctional parameters of the left ventricl peripheral artery endothelium disfunction, and painless myocardial ischemia in premenopausal women with hypertension. Kardiologiya. 2010; 50 (1): 16–21 (in Russ.)].
  45. Stimpel M. et al. Antihypertensive treatment in menopausal women – results from a prospective, randomized, double-blind, controlled study comparing an ACE inhibitor with diuretic. Cardiology. 1998; 89 (4): 271–6. DOI: 10.1159/000006799
  46. Habibulina M.M. Vlijanie dlitel'noj terapii Ko-dirotonom na remodelirovanie serdtsa, bezbolevuju ishemiju miokarda pri gipertonicheskoj bolezni s estrogenodefitsitom v premenopauze. Vrach. 2013; 9: 29–34 [Khabibulina M. Impact of long-term co-diroton therapy on heart remodelling, silent myocardial ischemia in hyprtensive disease with estrogen deficincy in premenopause. Vrach. 2013; 9: 29–34 (in Russ.)].
  47. Grodstein F., Manson J.E., Stampler M.J. Hormone therapy and coronary heart disease: the role of time since menopause and age at hormone initiation. J Women’s Health. 2006; 15: 35–44.
  48. Hsia J., Langer R.D., Manson J.E. et al.; Women’s Health Initiative Investigators. Conjugated equine estrogens and coronary heart disease: the Women’s Health Initiative. Arch Intern Med. 2006; 166 (DOI: 10.1001/archinte.166.3.357): 357–65. DOI: 10.1001/archinte.166.3.357
  49. Pines A., Sturdee D.W., Birkhauser M.H. IMS Updated Recommendations on postmenopausal hormone therapy. Climacteric. 2007; 10: 195–6. DOI: 10.1080/13697130701361657
  50. Ovsjannikova T.V., Makarov I.O., Kulikov I.A. Klinicheskaja effektivnost' negormonal'nyh metodov terapii u zhenschin v perimenopauze. Akusherstvo, ginekologija, reproduktsija. 2013; 7 (3): 26–9 [Ovsyannikova T.V., Makarov I.O., Kulikov I.A. Clinical efficacy of non-hormonal methods of therapy in perimenopausal women. Obstetrics, Gynecology and Reproduction. 2013; 7 (3): 26–9 (in Russ)].
  51. Petrova E., Kalistratov V., Polubojarinov P. i dr. Primenjaemyj pri klimakse preparat Femo-Klim – luchshee negormonal'noe reshenie gormonal'nyh problem. Vrach. 2019; 30 (1): 46–9 [Petrova E., Kalistratov V., Polyboyarinov P. et al. The menopause drug Femo-Klim is the best nonhormonal solution of hormonal problems. Vrach. 2019; 30 (1): 46–9 (in Russ)]. DOI: 10.29296/25877305-2019-01-08
  52. Habibulina M.M., Shamilov M.D. Vlijanie glitsina i lizinoprila na kachestvo zhizni zhenschin s arterial'noj gipertenziej i estrogenodefitsitom. Vrach. 2021; 32 (4): 38–42 [Khabibulina M., Shamilov M. The effect of glycine and lisinopril on quality of life in women with hypertension and estrogen deficiency Vrach. 2021; 32 (4): 38–42. (in Russ.)]. DOI: 10.29296/25877305-2021-04-06
  53. Potupchik T., Veselova O., Evert L. i dr. Spektr farmakologicheskih effektov glitsina. Vrach. 2015; 12: 14–7 [Potupchik T., Veselova O., Evert L. et al. A spectrum of pharmacological effects of glycine. Vrach. 2015; 12: 14–7 (in Russ)].
  54. Radzinskij V.E., Dobretsova T.A. Menopauza kak mehanizm zhenskogo starenija. Fitoestrogeny – razvedka boem. StatusPraesens. Ginekologija. Akusherstvo. Besplodnyj brak. 2015; 2 (25): 51–8 [Radzinskii V.E., Dobretsova T.A. Menopauza kak mekhanizm zhenskogo stareniya. Fitoestrogeny – razvedka boem. StatusPraesens. Ginekologiya. Akusherstvo. Besplodnyi brak. 2015; 2 (25): 51–8 (in Russ)].
  55. Radzinskij V.E., Dobretsova T.A., Ryzhova T.E. Biologicheskaja rol' menopauzal'nogo perehoda i terapevticheskie vozmozhnosti fitoestrogenov. StatusPraesens. Ginekologija. Akusherstvo. Besplodnyj brak. 2015; 4 (27): 77–82 [Radzinskii V.E., Dobretsova T.A., Ryzhova T.E. Biologicheskaya rol’ menopauzal’nogo perekhoda i terapevticheskie vozmozhnosti fitoestrogenov. StatusPraesens. Ginekologiya. Akusherstvo. Besplodnyi brak. 2015; 4 (27): 77–82 (in Russ)].
  56. Tatarova N.A., Linde V.A., Zhidkova E.V. i dr. Negormonal'naja korrektsija klimaktericheskih rasstrojstv v peri- i postmenopauze. Effektivnaja farmakoterapija v akusherstve i ginekologii. 2009; 17: 12–5 [Tatarova N.A., Linde V.A., Zhidkova E.V. et al. Negormonal’naya korrektsiya klimaktericheskikh rasstroistv v peri- i postmenopauze. Effektivnaya farmakoterapiya v akusherstve i ginekologii. 2009; 17: 12–5 (in Russ)].