Effect of bioantioxidant complex Arctium lappa L. and amino acids on regeneration processes in an experimental model

DOI: https://doi.org/10.29296/25877305-2022-02-05
Issue: 
2
Year: 
2022

Professor S. Trofimova(1), MD; Professor N. Chalisova(2), MD; A. Trofimov(1), PhD, MD; M.
Borts(3), Candidate of Engineering Sciences; E. Nikolaeva(3) (1)Saint Petersburg Institute of Bioregulation
and Gerontology (2)Pavlov Institute of Physiology Russian Academy of Sciences, Saint Petersburg (3)Chemical
and Biological Association «Firm VITA» Ltd, Saint Petersburg

The authors present the results of a preclinical study of regenerating pharmacological activity of the gel containing amino acids (Taurin, Arginine) and bioantioxidant complex Arctium lappa L. as active substances on the experimental model of chemical burns of the skin of animals.
Keywords: 
regeneration
amino acids Taurine
Arginine
bioantioxidant complex Arctium lappa L

References: 
  1. Vojtsehovskaja M.A. Vlijanie aminokislot, prirodnyh i sinteticheskih peptidov na kul'turu tkani kozhi molodyh i staryh krys. Avtoref. dis. … kand. biol. nauk. SPb, 2011; 34 s. [Voitsekhovskaya M.A. Vliyanie aminokislot, prirodnykh i sinteticheskikh peptidov na kul’turu tkani kozhi molodykh i starykh krys. Avtoref. dis. … kand. biol. nauk. SPb, 2011; 34 s. (in Russ.)].
  2. Gunin A.G., Kornilova N.K., Petrov V.V. i dr. Vozrastnye izmenenija chislennosti i proliferatsii fibroblastov v kozhe cheloveka. Uspehi gerontologii. 2011; 1: 45–9 [Gunin A.G., Kornilova N.K., Petrov V.V. et al. Age-related changes in the number and proliferation of fibroblasts in human skin. Uspekhi gerontologii. 2011; 24 (1): 45–9 (in Russ.)].
  3. Manturova N.E., Kononov A.V., Gorodilov R.V. Izmenenija kollagenovo-elasticheskogo karkasa kozhi i kletochnogo obnovlenija v epidermise pri starenii. Annaly plasticheskoj, rekonstruktivnoj i esteticheskoj hirurgii. 2010; 2: 89–94 [Manturova N.E., Kononov A.V., Gorodilov R.V. Age-related alterations in the collagen-elastic carcass of the skin and cellular renovation in epidermis. Annaly plasticheskoi, rekonstruktivnoi i esteticheskoi khirurgii. 2010; 2: 89–94 (in Russ.)].
  4. Otchet o rezul'tatah issledovanija fiziologo-biohimicheskih harakteristik i pasportizatsii shtamma kul'tury kletok lopuha bol'shogo ARCTIUM LAPPA L. «ShTAMM VITA-AL1» proizvodstva OOO «Himiko-biologicheskoe ob'edinenie pri RAN Firma «Vita», Sankt-Peterburg. Federal'noe gosudarstvennoe bjudzhetnoe uchrezhdenie nauki Institut fiziologii rastenij im. K.A. Timirjazeva Rossijskoj akademii nauk (IFR RAN) Institut toksikologii MZ RF. M., 2001; 15 s. [Otchet o rezul’tatakh issledovaniya fiziologo-biokhimicheskikh kharakteristik i pasportizatsii shtamma kul’tury kletok lopukha bol’shogo ARCTIUM LAPPA L. «ShTAMM VITA-AL1» proizvodstva OOO «Khimiko-biologicheskoe ob»edinenie pri RAN Firma «Vita», Sankt-Peterburg. Federal’noe gosudarstvennoe byudzhetnoe uchrezhdenie nauki Institut fiziologii rastenii im. K.A. Timiryazeva Rossiiskoi akademii nauk (IFR RAN) Institut toksikologii MZ RF. M., 2001; 15 s. (in Russ.)]
  5. Smirnov A.V., Chalisova N.I., Ryzhak G.A. i dr. Geroprotektornoe dejstvie aminokislot i tripeptidov v kul'ture tkani hrjascha krys. Uspehi gerontologii. 2011; 24 (1): 139–42 [Smirnov A.V., Chalisova N.I., Ryzhak G.A. et al. The geroprotective effect of the amino acids and tripeptides in tissue culture in the rats. Uspekhi gerontologii. 2011; 24 (1): 139–42 (in Russ.)].
  6. Smirnova I.O. Funktsional'naja morfologija starenija kozhi. Uspehi gerontologii. 2004; 13: 44–51 [Smirnova I.O. Functional morphology of skin agein. Uspekhi gerontologii. 2004; 13: 44–51 (in Russ.)].
  7. Trofimova S.V., Havinson V.H., Ivko O.M. i dr. Bioaktivnyj napitok. Patent RF na izobretenie №2377936 ot 10.01.2010 [Trofimova S.V., Khavinson V.Kh., Ivko O.M. et al. Bioaktivnyi napitok. Patent RF na izobretenie №2377936 ot 10.01.2010 (in Russ.)]
  8. Havinson V.H. Molekuljarnye osnovy peptidergicheskoĭ reguljatsii starenija. SPb: Nauka, 2011 [Khavinson V.Kh. Molekulyarnye osnovy peptidergicheskoi regulyatsii stareniya. SPb: Nauka, 2011 (in Russ.)].
  9. Havinson V.H., Lin'kova N.S., Kukanova E.O. Molekuljarnye mehanizmy snizhenija funktsional'noj aktivnosti kletok kozhi pri ee starenii. Uspehi fiziologicheskih nauk. 2016; 2: 62–76 [[Khavinson V.Kh., Linkova N.S., Kukanova E.O. et al. Molecular mechanisms of functional activity decreasing of the skin cells with its aging. Uspekhi fiziologicheskikh nauk. 2016; 47 (2): 62–76 (in Russ.)].
  10. Chalisova N.I., Kontsevaja E.A., Vojtsehovskaja M.A. i dr. Reguljatornoe vlijanie kodiruemyh aminokislot na osnovnye kletochnye protsessy u molodyh i staryh zhivotnyh. Uspehi gerontologii. 2011; 24 (2): 189–97 [Chalisova N.I., Kontsevaya E.A., Voytsekhovskaya M.A. et al. The regulated effect of the coded amino acids on the basic cellular processes in young and old animals. Uspekhi gerontologii. 2011; 24 (2): 189–97 (in Russ.)].
  11. Hertel' B. Molekuljarnye i kletochnye mehanizmy estestvennogo starenija i fotostarenija (stressornye faktory, zaschitnye mehanizmy). Kosmetika i meditsina. 2000; 4: 5–17 [Khertel’ B. Molekulyarnye i kletochnye mekhanizmy estestvennogo stareniya i fotostareniya (stressornye faktory, zashchitnye mekhanizmy). Kosmetika i meditsina. 2000; 4: 5–17 (in Russ.)].
  12. Amaro-Ortiz A., Yan B., D’Orazio J.A. Ultraviolet radiation, aging and the skin: prevention of damage by topical cAMP manipulation. Molecules. 2014; 19 (5): 6202–19. DOI: 10.3390/molecules19056202
  13. Blanpain C., Fuchs E. Epidermal stem cells of the skin. Annu Rev Cell Dev Biol. 2006; 22: 339–73. DOI: 10.1146/annurev.cellbio.22.010305.104357
  14. Foster A.R., Chami C.E., O’Neil C.A. et al. Osmolyte transporter expression is reduced in photoaged human skin: Implications for skin hydration in aging. Aging Cell. 2020; 19: 14. DOI: 10.1111/acel.13058
  15. Fuchs E. Skin stem cells: rising to the surface. J Cell Biol. 2008; 180 (2): 273–84. DOI: 10.1083/jcb.200708185
  16. Guna G. Theraprutic value of arctium lappa linn – a review. Asian J Pharm Clin Res. 2019; 12 (7): 53–9. DOI: 10.22159/ajpcr.2019.v12i7.33870
  17. Haydont V., Bernard B., Fortunel N. Age-related evolutions of the dermis: Clinical signs, fibroblast and extracellular matrix dynamics. Mech Ageing Dev. 2019; 177 (1): 150–6. DOI: 10.1016/j.mad.2018.03.006
  18. Hou B., Wang W., Gao H. et al. Effects of aqueous extract of Arctium lappa L. roots on serum lipid metabolism. J Int Med Res. 2018; 46 (1): 158–67. DOI: 10.1177/0300060517716341
  19. King-Chuen Wu, Hung-Kai Weng, Yun-Shang Hsu et al. Aqueous extract of Arctium lappa L. root (burdock) enhances chondrogenesis in human bone marrow-derived mesenchymal stem cells. BMC Complement Med Ther. 2020; 20 (1): 364. DOI: 10.1186/s12906-020-03158-1
  20. Matsumoto T., Hosono-Nishiyama K., Yamada H. Antiproliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells. Planta Med. 2006; 72: 276–84.
  21. Ogliari K., Marinowic D., Brum D. et al. Stem cells in dermatology. An Bras Dermatol. 2014; 89 (2): 286–91. DOI: 10.1590/abd1806-4841.20142530
  22. Tian X., Guo L.P., Hu X.L. et al. Protective effects on Actium lappa L. roots against hydrogen peroxide-induced cell injury and potential mechanisms in SH-SY5Y cells. Cell Mol Neurobiol. 2015; 35 (3): 335–44. DOI: 10.1007/s10571-014-0129-7
  23. Wang Z., Man M., Li T. et al. Aging-associated alterations in epidermal function and their clinical significance. Aging (Albany NY). 2020; 12 (6): 5551–65. DOI: 10.18632/aging.102946
  24. Yang W.S., Lee S.R., Jeong Y.J. et al. Antiallergic activity of ethanol extracts of Arctium lappa L. undried roots and its active compound. Oleamide, in regulating FcεRI-mediated and mapk signaling in RBL-2H3 cells. J Agric Food Chem. 2016; 64 (18): 3564–73. DOI: 10.1021/acs.jafc.6b00425